Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Neurobiology

• Publication date

  2017-11-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s12035-017-0809-7PMID 29164394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke

  2016cited by this paper
• NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

  2015cited by this paper
• SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes

  2012cited by this paper
• Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide

  2012cited by this paper
• RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen‐glucose deprivation combined with zVAD in primary cortical neurons

  2012cited by this paper
• A Novel Hydrogen Sulfide-releasing N-Methyl-d-Aspartate Receptor Antagonist Prevents Ischemic Neuronal Death*

  2012cited by this paper
• NAD+ Treatment Induces Delayed Autophagy in Neuro2a Cells Partially by Increasing Oxidative Stress

  2011cited by this paper
• NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

  2010influential reference
• Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD+ Synthesis in Cardiac Myocytes

  2009cited by this paper
• NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

  2008cited by this paper
• Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain

  2008cited by this paper
• Neuroprotective Effects of Leptin Against Ischemic Injury Induced by Oxygen-Glucose Deprivation and Transient Cerebral Ischemia

  2007cited by this paper
• Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury

  2007cited by this paper
• Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia.

  2007cited by this paper
• Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells.

  2007cited by this paper
• Mitochondrial respiratory chain and free radical generation in stroke.

  2005cited by this paper
• Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition*

  2004cited by this paper
• Neurological diseases: Mechanisms, challenges and opportunities in stroke

  2003cited by this paper
• Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

  2001cited by this paper
• Further randomized controlled trials of tPA within 3 hours are required-not!

  2001cited by this paper
• Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD+ and Inhibition of Glycolysis

  2000cited by this paper
• Long‐term deprivation of oestrogens by ovariectomy potentiates β‐amyloid‐induced working memory deficits in rats

  1999cited by this paper
• Monofilament intraluminal middle cerebral artery occlusion in the mouse.

  1997cited by this paper
• Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay.

  1997cited by this paper

• NADPH Exerts Neuroprotection in Ischemic Stroke by Reinforcing Blood-Brain Barrier Integrity and Stimulating Angiogenesis.

  2026cites this paper
• Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD+/Sirt1/FOXO1a pathway activation.

  2025cites this paper
• Attenuating Ischemia and Reperfusion Injury Using NAD+-Loaded Nanoparticles in Mouse Kidneys

  2025cites this paper
• Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP+] in different neural cell types and brain regions.

  2025cites this paper
• Metabolic Profiles of Probiotics with Polygonati Rhizoma Extract Stored at Different Temperatures by UHPLC-QE-MS/MS Approach

  2025cites this paper
• Transcriptomic Analysis of Lipid Accumulation in Mucor circinelloides WJ11 Under Submerged and Solid-State Fermentation

  2025cites this paper
• NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia

  2025cites this paper
• Nicotinamide riboside restores nicotinamide adenine dinucleotide levels and alleviates brain injury by inhibiting oxidative stress and neuroinflammation in a mouse model of intracerebral hemorrhage

  2024cites this paper
• Ovarian aging: energy metabolism of oocytes

  2024cites this paper
• Exogenous NADPH could mitigate pyroptosis-induced brain injury in fetal mice exposed to gestational intermittent hypoxia.

  2024cites this paper
• Effect of resuscitation of cryopreserved porcine adrenal glands at 26°C on their recovery and functioning under xenotransplantation.

  2024cites this paper
• Prussian blue nanotechnology in the treatment of spinal cord injury: application and challenges

  2024cites this paper
• NADPH mimics the antidepressant effects of exercise in a chronic unpredictable stress rat model.

  2024cites this paper
• Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis

  2023cites this paper
• The Role of Necroptosis in Cerebral Ischemic Stroke

  2023cites this paper
• Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure

  2023cites this paper
• Signaling pathways in brain ischemia: Mechanisms and therapeutic implications.

  2023cites this paper
• Bioinformatics analysis identifies the protective targets of omentin in mice with focal cerebral ischemia injury.

  2023cites this paper
• NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

  2023cites this paper
• Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases

  2023cites this paper
• Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice

  2023cites this paper
• Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats.

  2022cites this paper
• Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics

  2022cites this paper
• Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke

  2022cites this paper
• Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

  2022influential citation
• Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders

  2022cites this paper
• Role of NAD+ and FAD in Ischemic Stroke Pathophysiology: An Epigenetic Nexus and Expanding Therapeutic Repertoire

  2022cites this paper
• Time-of-day defines the efficacy of NAD+ to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock

  2022cites this paper
• Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia–Induced Blood–Brain Barrier Disruption Through NAD+/SIRT1 Signaling Pathway

  2021cites this paper
• One-Electron Reduction Triggered Nitric Oxide Release for Ischemia-Reperfusion Protection.

  2021cites this paper
• NADPH and Mito-Apocynin Treatment Protects Against KA-Induced Excitotoxic Injury Through Autophagy Pathway

  2021cites this paper
• Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease

  2021cites this paper
• Glucose metabolic crosstalk and regulation in brain function and diseases.

  2021cites this paper
• NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke

  2021cites this paper
• Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage

  2021cites this paper
• Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice

  2021cites this paper
• Comparison between slow and rapid freezing for adrenal gland cryopreservation and xenotransplantation.

  2021cites this paper
• Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

  2021cites this paper
• Exogenous Nicotinamide Adenine Dinucleotide Attenuates Postresuscitation Myocardial and Neurologic Dysfunction in a Rat Model of Cardiac Arrest

  2021cites this paper
• Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy

  2021cites this paper
• Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice

  2021cites this paper
• Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1.

  2021cites this paper
• Effect of Pioglitazone on Perihematomal Edema in Intracerebral Hemorrhage Mouse Model by Regulating NLRP3 Expression and Energy Metabolism

  2020cites this paper
• NADPH Protects against Kainic Acid-induced Excitotoxicity via Autophagy-lysosome Pathway in Rat Striatum and Primary Cortical Neurons.

  2020cites this paper
• NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.

  2020cites this paper
• A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.

  2020cites this paper
• The possible roles of necroptosis during cerebral ischemia and ischemia / reperfusion injury.

  2020cites this paper
• Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis

  2020cites this paper
• Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro

  2020cites this paper
• Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

  2020cites this paper
• SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions

  2019cites this paper
• Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging

  2019cites this paper
• Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review)

  2019cites this paper
• Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway

  2019cites this paper
• Nicotinamide and Demographic and Disease transitions: Moderation is Best

  2019cites this paper
• Systematic Review on the Involvement of the Kynurenine Pathway in Stroke: Pre-clinical and Clinical Evidence

  2019cites this paper
• PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All

  2019cites this paper
• TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.

  2019cites this paper
• Reduced nicotinamide adenine dinucleotide phosphate inhibits rat platelet aggregation and p38 phosphorylation.

  2018cites this paper
• Advances on Pathological Significance of Cerebral Microvascular Inflammatory Injury and Drug Discovery

  2018cites this paper
• The Role of Circular RNAs in Cerebral Ischemic Diseases: Ischemic Stroke and Cerebral Ischemia/Reperfusion Injury.

  2018cites this paper