Obesity hypertension: the emerging role of leptin in renal and cardiovascular dyshomeostasis

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Current opinion in nephrology and hypertension

• Publication date

  2010-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/MNH.0b013e328332fb49PMID 19851106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No Association Between Leptin Levels and Sleep Duration or Quality in Obese Adults

  2011cited by this paper
• Leptin and cardiovascular diseases

  2011cited by this paper
• Structural and functional changes in the kidneys of high-fat diet-induced obese mice.

  2009cited by this paper
• Sympathoexcitation by Oxidative Stress in the Brain Mediates Arterial Pressure Elevation in Obesity-Induced Hypertension

  2009cited by this paper
• Leptin Signaling in the Nucleus Tractus Solitarii Increases Sympathetic Nerve Activity to the Kidney

  2009cited by this paper
• Leptin attenuates cardiac apoptosis after chronic ischaemic injury.

  2009cited by this paper
• Mechanisms mediating renal sympathetic activation to leptin in obesity.

  2008cited by this paper
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases.

  2008cited by this paper
• A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.

  2008cited by this paper
• Leptin and its metabolic interactions – an update

  2008cited by this paper
• Neural Integration of Peripheral Signals Implicated in the Control of Energy Homeostasis and Metabolism Mechanisms mediating renal sympathetic activation to leptin in obesity

  2008cited by this paper
• Hyperleptinemia--non-haemodynamic risk factor for the left ventricular hypertrophy development in hypertensive overweight females.

  2008cited by this paper
• Blood Pressure and Vascular Effects of Leptin in Humans

  2007cited by this paper
• Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.

  2007cited by this paper
• Leptin as a cardiac hypertrophic factor: a potential target for therapeutics.

  2007cited by this paper
• Effects of leptin on cardiovascular physiology.

  2007cited by this paper
• Prevalence of overweight and obesity in the United States, 1999-2004.

  2006cited by this paper
• Leptin and inflammation-associated cachexia in chronic kidney disease.

  2006cited by this paper
• Role of leptin in blood pressure regulation and arterial hypertension

  2006cited by this paper
• An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1.

  2006cited by this paper
• Anorexia in hemodialysis patients: an update.

  2006cited by this paper
• Leptin blockade attenuates sodium excretion in saline-loaded normotensive rats

  2006cited by this paper
• Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men.

  2006cited by this paper
• Leptin and Renal Disease

  2006cited by this paper
• Leptin and renal fibrosis.

  2006cited by this paper
• Leptin in end stage renal disease (ESRD): a link between fat mass, bone and the cardiovascular system.

  2005cited by this paper
• Fat as an Endocrine Organ: Relationship to the Metabolic Syndrome

  2005cited by this paper
• Obesity-associated hypertension: new insights into mechanisms.

  2005cited by this paper
• Role of leptin and melanocortin signaling in uremia-associated cachexia.

  2005cited by this paper
• Molecular and anatomical determinants of central leptin resistance

  2005cited by this paper
• High-calorie supplementation increases serum leptin levels and improves response to rHuEPO in long-term hemodialysis patients.

  2005cited by this paper
• The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology.

  2005cited by this paper
• Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD.

  2005cited by this paper
• Leptin and cardiovascular diseases.

  2005cited by this paper
• Role of leptin in the development of cardiac hypertrophy in experimental animals and humans.

  2004cited by this paper
• Pathophysiology and treatment of obesity hypertension.

  2004cited by this paper
• Influence of intravenously administered leptin on nitric oxide production, renal hemodynamics and renal function in the rat.

  2004cited by this paper
• Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways.

  2004cited by this paper
• Effects of chronic nitric oxide inhibition on the renal excretory response to leptin.

  2004cited by this paper
• The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes

  2003cited by this paper
• Serum leptin in dialysis renal osteodystrophy.

  2003cited by this paper
• Adipose tissue as a source of inflammatory cytokines in health and disease: focus on end-stage renal disease.

  2003cited by this paper
• Role of Leptin in the Regulation of Body Fluid Volume and Pressures

  2003cited by this paper
• Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity.

  2003cited by this paper
• Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure

  2003cited by this paper
• Cardiovascular and Renal Actions of Leptin

  2003cited by this paper
• Effect of renin-angiotensin system activation by dietary sodium restriction and upright position on plasma leptin concentration in patients with essential hypertension.

  2002cited by this paper
• Leptin and renal disease.

  2002cited by this paper
• The concept of selective leptin resistance: evidence from agouti yellow obese mice.

  2002cited by this paper
• Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice

  2002cited by this paper
• Human leptin administered intraperitoneally stimulates natriuresis and decreases renal medullary Na+, K+-ATPase activity in the rat -- impaired effect in dietary-induced obesity.

  2002cited by this paper
• Acute changes in the response to peripheral leptin with alteration in the diet composition.

  2001cited by this paper
• Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity.

  2001cited by this paper
• Does Leptin Stimulate Nitric Oxide to Oppose the Effects of Sympathetic Activation?

  2001cited by this paper
• Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass.

  2000cited by this paper
• Activation of Downstream Signals by the Long Form of the Leptin Receptor*

  2000cited by this paper
• Pathophysiological role of leptin in obesity-related hypertension.

  2000cited by this paper
• Leptin Attenuates Cardiac Contraction in Rat Ventricular Myocytes: Role of NO

  2000cited by this paper
• Leptin induces direct vasodilation through distinct endothelial mechanisms.

  2000cited by this paper
• Regional haemodynamic effects of recombinant murine or human leptin in conscious rats

  2000cited by this paper
• Effects of renal denervation on the sodium excretory actions of leptin in hypertensive rats.

  2000cited by this paper
• Leptin induces oxidative stress in human endothelial cells

  1999cited by this paper
• Molecular Basis of Renal Disease Molecular studies of leptin : implications for renal disease

  1999cited by this paper
• Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice.

  1999cited by this paper
• Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men.

  1999cited by this paper
• Hyperleptinemia in uremic patients undergoing conservative management, peritoneal dialysis, and hemodialysis: A comparative analysis.

  1999cited by this paper
• Pivotal role of nitric oxide in the control of blood pressure after leptin administration.

  1999cited by this paper
• Association of the serum leptin concentration with weight loss in chronic hemodialysis patients.

  1999cited by this paper
• Low leptin gene expression and hyperleptinemia in chronic renal failure.

  1998cited by this paper
• Hyperleptinaemia in chronic heart failure. Relationships with insulin.

  1998cited by this paper
• Identification of SOCS-3 as a potential mediator of central leptin resistance.

  1998cited by this paper
• Renal effects of leptin in normotensive, hypertensive, and obese rats.

  1998cited by this paper
• Biological action of leptin as an angiogenic factor.

  1998cited by this paper
• Leptin, body composition, and indices of malnutrition in patients on dialysis.

  1998cited by this paper
• Chronic leptin infusion increases arterial pressure.

  1998cited by this paper
• Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure.

  1997cited by this paper
• Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice.

  1997cited by this paper
• Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization.

  1997cited by this paper
• Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion

  1997cited by this paper
• Human leptin has natriuretic activity in the rat.

  1997cited by this paper
• Receptor-mediated regional sympathetic nerve activation by leptin.

  1997cited by this paper
• Removal of endogenous leptin from the circulation by the kidney

  1997cited by this paper
• Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure.

  1997cited by this paper
• Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells.

  1997cited by this paper
• Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

  1997cited by this paper
• Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients.

  1997cited by this paper
• Characterization and localization of leptin receptors in the rat kidney

  1997cited by this paper
• Pressure-dependent renin release during chronic blockade of nitric oxide synthase.

  1996cited by this paper
• Leptin, its receptor and obesity.

  1996cited by this paper
• A novel leptin receptor isoform in rat

  1996cited by this paper
• Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

  1996cited by this paper
• The obese (ob) gene and its product leptin—a new route toward obesity treatment in man?

  1996cited by this paper
• Eosinophilic gastrojejunitis associated with connective tissue disease.

  1996cited by this paper
• Identification and expression cloning of a leptin receptor, OB-R.

  1995cited by this paper
• Incidence and precursors of hypertension in young adults: the Framingham Offspring Study.

  1987cited by this paper
• The kidney in the pathogenesis of hypertension: the role of renal nerves.

  1985cited by this paper

• Adipokines Level and Cognitive Function—Disturbance in Homeostasis in Older People with Poorly Managed Hypertension: A Pilot Study

  2022cites this paper
• Association between plasma leptin/adiponectin ratios with the extent and severity of coronary artery disease

  2020cites this paper
• An assessment of platelet parameters in different ethnic groups with hypertension subtypes and associated risk factors in Xinjiang, China

  2018cites this paper
• Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice

  2016cites this paper
• Encapsulation of Genetically Modified Preadipocytes for Potential Treatment of Metabolic Disorders

  2015cites this paper
• Adiposidad abdominal, insulino-resistencia, hipertensión y sodio urinario en adolescentes obesos

  2014cites this paper
• Effects of Chitosan on Plasma Lipids and Lipoproteins

  2014cites this paper
• Exercise prevents leptin-induced increase in blood pressure in Sprague–Dawley rats

  2014cites this paper
• Expanded roles of the renin–angiotensin system

  2013cites this paper
• obesidad y excreción urinaria de sodio en niños y adolescentes

  2012cites this paper
• Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II.

  2012cites this paper
• Leptin, insulin resistance, and metabolic changes 5 years after renal transplantation.

  2012cites this paper
• Modulation of the cardiovascular system by leptin.

  2012cites this paper
• RISCO CARDIOVASCULAR NA HIPERTENSÃO DO AVENTAL BRANCO: AVALIAÇÃO DO ÍNDICE TORNOZELO BRAQUIAL

  2012cites this paper
• Which Life Style Anthropometric Index is a Better Predictor of Renal Function?

  2012cites this paper
• Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats.

  2012cites this paper
• Niveles séricos de leptina y su relación con la excreción de sodio en niños y adolescentes obesos

  2011cites this paper
• Niveles séricos de leptina y su relación con la excreción de sodio en niños y adolescentes obesos Relationship between serum leptin levels and sodium excretion in a local population of obese children and adolescents

  2011influential citation
• No Association Between Leptin Levels and Sleep Duration or Quality in Obese Adults

  2011cites this paper
• Effects of weight loss on renal function in overweight Japanese men

  2011cites this paper
• [The role of leptin, adiponectin and insulin-resistance markers in development of early stages of chronic kidney disease and atherosclerosis of carotid arteries in obese patients].

  2011cites this paper
• EFECTO DEL EJERCICIO FÍSICO AERÓBICO SOBRE LOS NIVELES SÉRICOS DE ADIPONECTINA Y LEPTINA EN MUJERES POSMENOPÁUSICAS

  2011cites this paper
• Obstructive sleep apnea and glucose metabolism

  2011cites this paper
• Leptin stimulates phosphoinositide 3-kinase in the vascular wall: role of ErbB receptors

  2011influential citation
• Conséquences rénales de l’obésité

  2011cites this paper
• Atrial Natriuretic Peptide and Leptin in Obesity-associated Hypertension in Middle-aged Egyptian Women

  2011cites this paper
• [Renal consequences of obesity].

  2011cites this paper
• Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?

  2011cites this paper