Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  In Vitro Cellular & Developmental Biology - Animal

• Publication date

  1999-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11626-999-0080-yPMID 10476917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ifosfamide Metabolite Chloroacetaldehyde Causes Renal Dysfunction in vivo

  1997cited by this paper
• Primary kidney cells.

  1997cited by this paper
• Renal clearance of ifosfamide.

  1997cited by this paper
• Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats.

  1996cited by this paper
• Identification of new metabolites of ifosfamide in rat urine using ion cluster technique

  1995cited by this paper
• Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells.

  1995cited by this paper
• Ifosfamide and mesna: effects on the Na/H exchanger activity in renal epithelial cells in culture (LLC-PK1).

  1995cited by this paper
• A prospective evaluation of ifosfamide‐related nephrotoxicity in children and young adults

  1995cited by this paper
• Effects of glutathione depletion on the cytotoxic actions of cadmium in LLC-PK1 cells.

  1995cited by this paper
• Diethyldithiocarbamate protection against cisplatin nephrotoxicity: antioxidant system.

  1995cited by this paper
• Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna

  1994cited by this paper
• Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection.

  1994cited by this paper
• Ifosfamide Clinical Pharmacokinetics

  1994cited by this paper
• Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture

  1994cited by this paper
• Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney.

  1994cited by this paper
• Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells

  1994cited by this paper
• Ifosfamide, mesna, and nephrotoxicity in children.

  1993cited by this paper
• Oxidant-induced alterations in glucose and phosphate transport in LLC-PK1 cells: mechanisms of injury.

  1993cited by this paper
• Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes.

  1993cited by this paper
• Inhibition of sodium-dependent transport systems in LLC-PK1 cells by metabolites of ifosfamide.

  1992cited by this paper
• Primary kidney cells.

  1990cited by this paper
• Primary cultures of rabbit renal proximal tubule cells: II. Selected phase I and phase II metabolic capacities.

  1990cited by this paper
• Toxicity determined in vitro by morphological alterations and neutral red absorption.

  1985cited by this paper
• Transport and metabolism of glucose by renal proximal tubular cells in primary culture.

  1984cited by this paper
• Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.

  1983cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Safety of ifosfamide during pregnancy: A comprehensive analysis.

  2025cites this paper
• Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways.

  2025cites this paper
• A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure

  2024cites this paper
• Pretreatment with Chrysin Reduces Ifosfamide-Induced Acute Nephrotoxicity in Male Rats through Mitochondrial Protection

  2024cites this paper
• Pretreatment of ellagic acid protects ifosfamide-induced acute nephrotoxicity in rat kidneys: A mitochondrial, histopathological and oxidative stress approaches

  2023cites this paper
• Studies with Human-Induced Pluripotent Stem Cells Reveal That CTNS Mutations Can Alter Renal Proximal Tubule Differentiation

  2023cites this paper
• The Nephrotoxicity of Drugs Used in Causal Oncological Therapies

  2022cites this paper
• Dissecting Drug-Induced Cytotoxicity and Metabolic Dysfunction in Conditionally Immortalized Human Proximal Tubule Cells

  2022cites this paper
• Dissecting drug-induced in vitro cytotoxicity and metabolic dysfunction in conditionally immortalized human proximal tubule cells

  2021cites this paper
• Hypophosphatemia in cancer patients

  2021cites this paper
• Predicting Metabolism‐Related Drug–Drug Interactions Using a Microphysiological Multitissue System

  2020cites this paper
• The footprints of mitochondrial impairment and cellular energy crisis in the pathogenesis of xenobiotics-induced nephrotoxicity, serum electrolytes imbalance, and Fanconi's syndrome: A comprehensive review.

  2019cites this paper
• Partial Fanconi syndrome induced by ifosfamide

  2019cites this paper
• Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning.

  2019cites this paper
• Ifosfamide nephrotoxicity in adult patients

  2019cites this paper
• [Ifosphamide nephrotoxicity].

  2018cites this paper
• Néphrotoxicité de l ’ ifosfamide Ifosphamide nephrotoxicity

  2018cites this paper
• A Predominant Oxidative Renal Metabolite of Empagliflozin in Male Mice Is Cytotoxic in Mouse Renal Tubular Cells but not Genotoxic

  2017cites this paper
• POTENTIAL NEPHROPROTECTIVE EFFECT OF SILYMARIN AGAINST IFOSFAMIDE INDUCED TOXICITY IN RATS

  2015cites this paper
• Protective effects of alpha lipoic acid versus N-acetylcysteine on ifosfamide-induced nephrotoxicity

  2015influential citation
• Hydroxylation and N-Dechloroethylation of Ifosfamide and Deuterated Ifosfamide by the Human Cytochrome P450s and Their Commonly Occurring Polymorphisms

  2015cites this paper
• Drug-induced acute kidney injury in children.

  2015cites this paper
• POTENTIAL NEPHROPROTECTIVE EFFECT OF SILYMARIN AGAINST IFOSFAMIDE INDUCED TOXICITY IN RATS

  2015cites this paper
• Ifosfamide-Induced Fanconi's Syndrome

  2014cites this paper
• N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention

  2013cites this paper
• N-acetylcysteine rescue protocol for nephrotoxicity in children caused by ifosfamide.

  2013cites this paper
• The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft model.

  2012cites this paper
• N‐acetylcysteine as a Novel Prophylactic Treatment for Ifosfamide‐Induced Nephrotoxicity in Children: Translational Pharmacokinetics

  2012cites this paper
• Effect of Storing Temperature on Hepatotoxicity and Nephrotoxicity of Ifosfamide in Female Rat

  2012cites this paper
• Solid Lipid Nanoparticulate Formulation for ifosfamide: Development and Characterization

  2011cites this paper
• The effect of N-acetylcysteine on the antitumor activity of ifosfamide.

  2011cites this paper
• Oxazaphosphorines: new therapeutic strategies for an old class of drugs

  2010cites this paper
• Alkylation of Adenosine Deaminase and Thioredoxin by Acrylamide in Human Cell Cultures

  2009cites this paper
• Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention

  2009influential citation
• Chloroacétaldéhyde : de l’implication dans les mécanismes physiopathologiques de la néphrotoxicité de l’ifosfamide à la contribution à son effet anticancéreux

  2009influential citation
• Detection and quantification of (R) and (S)-dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS.

  2009cites this paper
• Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.

  2008cites this paper
• N‐Acetylcysteine prevents ifosfamide‐induced nephrotoxicity in rats

  2008cites this paper
• In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro

  2008cites this paper
• The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells.

  2007cites this paper
• Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations.

  2007cites this paper
• Steady State Concentration [ Css ] and Total Clearance Rate of NAC in Adults , Neonates and Children

  2007cites this paper
• Ifosfamide toxicity in cultured proximal renal tubule cells

  2007influential citation
• Resveratrol improves ifosfamide-induced Fanconi syndrome in rats.

  2007cites this paper
• Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells

  2007cites this paper
• Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells.

  2006cites this paper
• Enantioselective metabolism of ifosfamide by the kidney.

  2006cites this paper
• CONTRIBUTION OF CYP3A5 TO HEPATIC AND RENAL IFOSFAMIDE N-DECHLOROETHYLATION

  2005cites this paper
• Primary kidney proximal tubule cells.

  2005cites this paper
• Role of GSTM1, GSTP1, and GSTT1 Gene Polymorphism in Ifosfamide Metabolism Affecting Neurotoxicity and Nephrotoxicity in Children

  2005cites this paper
• Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells

  2005cites this paper
• A tubule cell model for ifosfamide nephrotoxicity.

  2005influential citation
• Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels.

  2004cites this paper
• Renal ontogeny of ifosfamide nephrotoxicity.

  2004cites this paper
• Melatonin attenuates ifosfamide‐induced Fanconi syndrome in rats

  2004cites this paper
• Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.

  2003cites this paper
• Developmental renal tubular toxicity: a hypothetical framework and experimental approaches☆

  2001cites this paper
• Primary kidney cells.

  1997cites this paper
• The Nitrogen Mustards

  1951influential citation