DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Dalton Transactions

• Publication date

  2009-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/b911542kPMID 20023915
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

  2008cited by this paper
• Synthesis, spectroscopy, X-ray structure and redox behaviors of 4-(N-R-salicylideneimine)-2,6-diphenylphenols.

  2008cited by this paper
• Phenanthroline Derivatives with Improved Selectivity as DNA‐Targeting Anticancer or Antimicrobial Drugs

  2008cited by this paper
• Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

  2008cited by this paper
• Synthesis and Activity of a Trinuclear Platinum Complex: [{trans‐PtCl(NH3)2}2μ‐{trans‐Pt(3‐hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in Ovarian Cancer Cell Lines

  2008cited by this paper
• A short history of SHELX.

  2008cited by this paper
• Influence of the Copper Coordination Geometry on the DNA Cleavage Activity of Clip‐Phen Complexes Studied by DFT

  2008cited by this paper
• Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

  2008cited by this paper
• Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

  2008cited by this paper
• The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy.

  2008cited by this paper
• Synthesis and activity of a trinuclear platinum complex: [{trans-PtCl(NH3)2}2mu-{trans-Pt(3-hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in ovarian cancer cell lines.

  2008cited by this paper
• The resurgence of platinum-based cancer chemotherapy

  2007cited by this paper
• Unique ligand-based oxidative DNA cleavage by zinc(II) complexes of hpyramol and hpyrimol.

  2007cited by this paper
• Synthetic metallomolecules as agents for the control of DNA structure.

  2007cited by this paper
• 195Pt NMR--theory and application.

  2007cited by this paper
• Direct cellular responses to platinum-induced DNA damage.

  2007cited by this paper
• Broadening the clinical use of platinum drug–based chemotherapy with new analogues

  2007cited by this paper
• Cisplatin : chemistry and biochemistry of a leading anticancer drug

  2006cited by this paper
• An Overview of 195Pt Nuclear Magnetic Resonance Spectroscopy

  2006cited by this paper
• Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.

  2006cited by this paper
• The square-planar cytotoxic [Cu(II)(pyrimol)Cl] complex acts as an efficient DNA cleaver without reductant.

  2006cited by this paper
• Interaction of rac-[Ru(5,6-dmp)3]2+ with DNA: enantiospecific DNA binding and ligand-promoted exciton coupling.

  2006cited by this paper
• Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules

  2006cited by this paper
• The Square-Planar Cytotoxic [CuII(pyrimol)Cl] Complex Acts as an Efficient DNA Cleaver without Reductant

  2006cited by this paper
• Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.

  2005cited by this paper
• Cellular processing of platinum anticancer drugs

  2005cited by this paper
• Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes.

  2005cited by this paper
• Synthesis, structure, and reactivity of monofunctional platinum(II) and palladium(II) complexes containing the sterically hindered ligand 6-(methylpyridin-2-yl)acetate.

  2005cited by this paper
• Studies on activities, cell uptake and DNA binding of four trans-planaramineplatinum(II) complexes of the form: trans-PtL(NH3)Cl2, where L=2-hydroxypyridine, imidazole, 3-hydroxypyridine and imidazo(1,2-alpha)pyridine.

  2004cited by this paper
• Intramolecular oxidation of the ligand 4-methyl-2-N-(2-pyridylmethyl)aminophenol (Hpyramol) upon coordination with iron(II) chloride and manganese(II) perchlorate

  2004cited by this paper
• New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA

  2003cited by this paper
• An intensity evaluation method: EVAL-14

  2003cited by this paper
• Medicinal applications of heavy-metal compound

  1999cited by this paper
• Why does Cisplatin reach Guanine-n7 with competing s-donor ligands available in the cell?

  1999cited by this paper
• Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

  1999cited by this paper
• Medicinal applications of heavy-metal compounds.

  1999cited by this paper
• Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation.

  1994cited by this paper
• Journal of

  1993cited by this paper
• Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

  1992cited by this paper
• Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents.

  1991cited by this paper
• Simple construction of an infrared optically transparent thin-layer electrochemical cell: Applications to the redox reactions of ferrocene, Mn2(CO)10 and Mn(CO)3(3,5-di-t-butyl-catecholate)−

  1991cited by this paper
• Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.

  1991cited by this paper
• 1H NMR studies of tris(phenanthroline) metal complexes bound to oligonucleotides: structural characterizations via selective paramagnetic relaxation.

  1990cited by this paper
• The interaction of aquated platinum(II) compounds with purine mononucleotides

  1984cited by this paper
• Dynamic filtering by two-dimensional 1H NMR with application to phage lambda repressor.

  1984cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Cancer: Principles and Practice of Oncology

  1983cited by this paper

• Metal Oxide Nanoparticles Having Strong Physico- and Electrochemical Interaction with Genetic Material Will Have Better Anticancer Efficacy

  2024cites this paper
• Mechanistic Studies of Arene–Ruthenium(II) Complexes with Carbothioamidopyrazoles as Alternative Cancer Drugs

  2023cites this paper
• Copper(ii) complexes of 2-methyl-8-hydroxyquinoline and tri/diimine co-ligand: DFT calculations, DNA and BSA binding, DNA cleavage, cytotoxicity and induction of apoptosis

  2021cites this paper
• Cytotoxic oxidovanadium(IV) complexes of tridentate halogen-substituted Schiff bases: First dinuclear V(IV) complexes with O→VIV=O→VIV=O core.

  2021cites this paper
• Sentezlenen Yeni Ni (II) Komplekslerinin Spektroskopik ve antifungal özelliklerinin İncelenmesi

  2020cites this paper
• Developing novel zinc(ii) and copper(ii) Schiff base complexes: combined experimental and theoretical investigation on their DNA/protein binding efficacy and anticancer activity

  2020cites this paper
• Yeni sentezlenen Ni (II) Kompleks Bileşiklerin sentezi, Spektroskopik ve antibakteriyel özelliklerinin İncelenmesi

  2020cites this paper
• Ternary Cu(II) complexes: synthesis, structural elucidation, and biological studies (DNA binding, cleavage, antibacterial, cytotoxicity)

  2020cites this paper
• Three Pt-Pt Complexes with Donor-Acceptor Feature: Anticancer Activity, DNA Binding Studies and Molecular Docking Simulation.

  2019cites this paper
• Novel Fluorine Boron Hybrid Complex as Potential Antiproliferative Drugs on Colorectal Cancer Cell Line.

  2019cites this paper
• Synthesis, spectroscopic properties and DFT studies of copper(II) complex of (E)-1-((2,4-dichlorophenylimino)methyl)naphthalen-2-ol

  2019cites this paper
• Novel water soluble bis(μ‐chloro) bridged Cu(II) binuclear and mononuclear complexes: Synthesis, characterization and biological evaluation

  2018cites this paper
• Experimental, DFT Calculation, Biological Activity, Anion Sensing Application Studies and Crystal Structure of (E)-4-[(pyridin-3-ylimino)methyl]benzene-1,3-diol

  2018cites this paper
• pH-Driven preparation of two related platinum(ii) complexes exhibiting distinct cytotoxic properties.

  2017cites this paper
• Theoretical investigation on molecular structure of a new mononuclear copper(II) thiocyanato complex with tridentate Schiff base ligand

  2017cites this paper
• Synthesis and Application of Polymer Stabilized, Water Dispersible Copper Based Nanoparticles as Anti-cancer and Diagnostic Agents

  2017cites this paper
• Review: electrochemical studies on some metal complexes having anti-cancer activities

  2017cites this paper
• Structure dependent selective efficacy of pyridine and pyrrole based Cu(II) Schiff base complexes towards in vitro cytotoxicity, apoptosis and DNA-bases binding in ground and excited state.

  2016cites this paper
• Water Soluble Copper(II) and Zinc(II) Complexes of Mangiferin: Synthesis, Antitumour Activity and DNA Binding Studies

  2016cites this paper
• Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes

  2016cites this paper
• A water-soluble Pd(II) complex with a terpyridine ligand: experimental and molecular modeling studies of the interaction with DNA and BSA; and in vitro cytotoxicity investigations against five human cancer cell lines

  2016cites this paper
• Novel pyrazole fused heterocyclic ligands： Synthesis, characterization, DNA binding/cleavage activity and anti-BVDV activity

  2015cites this paper
• Cytotoxic potency of self-assembled Ruthenium(II)-NHC complexes with pincer type 2, 6-bis(N-methylimidazolylidene/benzimidazolylidene)pyrazine ligands.

  2015cites this paper
• Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(II) complexes.

  2015cites this paper
• Extracellularly synthesized ZnO nanoparticles interact with DNA and augment gamma radiation induced DNA damage through reactive oxygen species

  2015cites this paper
• Synthesis, biological activity, DNA binding and anion sensors, molecular structure and quantum chemical studies of a novel bidentate Schiff base derived from 3,5-bis(triflouromethyl)aniline and salicylaldehyde

  2015cites this paper
• Antioxidant and DNA binding studies of Cu(II) complexes of N,N′-(1,1′-dithio-bis(phenylene))-bis(salicylideneimine): synthesis and characterization

  2015cites this paper
• Synthesis, crystal structure, cytotoxicity and cell apoptosis induction of a copper(II)-based Schiff base complex

  2014cites this paper
• Oxidative stress induced by copper and iron complexes with 8-hydroxyquinoline derivatives causes paraptotic death of HeLa cancer cells.

  2014cites this paper
• Anticancer activity and DNA-binding properties of novel cationic Pt(II) complexes.

  2014cites this paper
• Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies.

  2014cites this paper
• Advances in copper complexes as anticancer agents.

  2014cites this paper
• Mixed ligand μ-phenoxo-bridged dinuclear copper(II) complexes with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity.

  2014cites this paper
• Novel Pt(II) complexes containing pyrrole oxime; synthesis, characterization and DNA binding studies

  2014cites this paper
• Nuclease and anti-proliferative activities of copper(II) complexes of N3O tripodal ligands involving a sterically hindered phenolate.

  2013cites this paper
• TCM active ingredient oxoglaucine metal complexes: crystal structure, cytotoxicity, and interaction with DNA.

  2012cites this paper
• Multifunctional ligands in medicinal inorganic chemistry--current trends and future directions.

  2012cites this paper
• Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro.

  2012cites this paper
• Metal ion-promoted conformational changes of oligonucleotides.

  2012cites this paper
• Synthesis and characterization of a neutral titanium tris(iminosemiquinone) complex featuring redox-active ligands.

  2012cites this paper
• Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties

  2012cites this paper
• Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame.

  2012cites this paper
• Efficient DNA cleavage mediated by mononuclear mixed ligand copper(II) phenolate complexes: the role of co-ligand planarity on DNA binding and cleavage and anticancer activity.

  2012cites this paper
• Synthesis, characterization, interaction with DNA, and cytotoxic effect in vitro of new mono- and dinuclear Pd(II) and Pt(II) complexes with benzo[d]thiazol-2-amine as the primary ligand.

  2011cites this paper
• Study on potential antitumor mechanism of a novel Schiff base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity.

  2011cites this paper
• The synthetic and biological studies of discorhabdins and related compounds.

  2011cites this paper
• Copper(II) complexes with tridentate pyrazole-based ligands: synthesis, characterization, DNA cleavage activity and cytotoxicity.

  2011cites this paper
• Copper curcuminoids containing anthracene groups: fluorescent molecules with cytotoxic activity.

  2010cites this paper
• Reaction mechanisms in solution

  2009cites this paper