LOCUS OF EMETIC ACTION OF EPINEPHRINE AND DOPA IN DOGS

Intravenous injection of epinephrine and dopa induced vomiting in dogs after an average latency of 70 seconds and 117 seconds, respectively. The ED50 of epinephrine HCl and dopa in provoking emesis in dogs is 0.052 mg/kg and 0.79 mg/kg, respectively. Epinephrine is 15.0 times more potent than dopa in inducing emesis. Epinephrine-induced emesis was only inconsistently blocked by trigger zone ablation. There was no correlation between the elevation of emetic threshold to epinephrine and the elevation of the apomorphine threshold or the completeness of trigger zone ablation. On the other hand, the same operation renders dogs completely refractory to dopa-induced emesis. Gut denervation did not alter its threshold. These results suggest that dopa, like apomorphine, provokes emesis only via the trigger mechanism. Perphenazine was highly effective in preventing emesis induced by dopa, but not as effective in preventing that caused by epinephrine. On the other hand, the antiemetic effects of glycine against dopa and epinephrine do not differ. Atropine exerted no antiemetic effect on epinephrine-induced emesis.

• Publication year

  1963

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1963-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/s0022-3565(25)26500-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

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