Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Osteoarthritis and Cartilage

• Publication date

  2014-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.joca.2014.02.007PMID 24576742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis

  2013cited by this paper
• Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project.

  2012cited by this paper
• [The Rotterdam study].

  2011cited by this paper
• Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis.

  2011cited by this paper
• Protein Modification by Deamidation Indicates Variations in Joint Extracellular Matrix Turnover*

  2011cited by this paper
• Application of biochemical markers in development of drugs for treatment of osteoarthritis

  2010cited by this paper
• First Qualification Study of Serum Biomarkers as Indicators of Total Body Burden of Osteoarthritis

  2010cited by this paper
• Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.

  2010cited by this paper
• Clinical Laboratory Tests: Which, Why, and What Do The Results Mean?

  2009cited by this paper
• Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.

  2008cited by this paper
• Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study

  2007cited by this paper
• The Rotterdam Study: 2010 objectives and design update

  2007cited by this paper
• Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study.

  2007cited by this paper
• Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity

  2006cited by this paper
• Does hand osteoarthritis predict future hip or knee osteoarthritis?

  2005cited by this paper
• Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study

  2004cited by this paper
• A new marker for osteoarthritis: cross-sectional and longitudinal approach.

  2004cited by this paper
• Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis

  2003cited by this paper
• Collagen type II C-telopeptide fragments as an index of cartilage degradation.

  2001cited by this paper
• The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study.

  2000cited by this paper
• Characterization of monoclonal antibodies recognizing different fragments of cartilage oligomeric matrix protein in human body fluids.

  1997cited by this paper
• The association between osteoarthritis and osteoporotic fracture: the Chingford Study.

  1996cited by this paper
• The classification and assessment of osteoarthritis.

  1995cited by this paper
• Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.

  1995cited by this paper

• The role of type I collagen fragment C1M in knee osteoarthritis. A longitudinal biomarker study using data from the OA-FNIH consortium.

  2026cites this paper
• Are there associations between bone turnover and hip geometry in the general population?

  2025cites this paper
• Serum sampling proximal to the joint or after exercise influences biomarker concentration and potentially improves understanding of joint microenvironment: a pilot case-control study

  2025cites this paper
• Hyaluronanized gold nanoparticles functionalized with CTX-II antibody for early diagnosis and treatment of knee osteoarthritis

  2025cites this paper
• COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair

  2025cites this paper
• Cartilage turnover, but not novel synovial collagen marker, is associated with joint damage progression in osteoarthritis patients.

  2025cites this paper
• Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial

  2025cites this paper
• An osteoarthritis pathophysiological continuum revealed by molecular biomarkers

  2024cites this paper
• Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease

  2024cites this paper
• Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population - findings from the ADVANCE study.

  2024cites this paper
• Cartilage oligomeric matrix protein as a potential biomarker for knee osteoarthritis

  2024cites this paper
• Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage

  2024cites this paper
• Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with non-severe hemophilia A (DYNAMO study).

  2023cites this paper
• Plasma Cartilage Acidic Protein 1 Measured by ELISA Is Associated With the Progression to Total Joint Replacement in Postmenopausal Women

  2023cites this paper
• Recent targets of osteoarthritis research.

  2023cites this paper
• Reflections from the OARSI 2022 clinical trials symposium: The pain of OA-Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design.

  2023cites this paper
• Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics

  2023cites this paper
• Soluble and EV-Associated Diagnostic and Prognostic Biomarkers in Knee Osteoarthritis Pathology and Detection

  2023cites this paper
• Generation of Matrix Degradation Products Using an In Vitro MMP Cleavage Assay

  2022cites this paper
• Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study

  2022cites this paper
• The use of collagen type-II as an indicator for assessment regeneration effect post intra-articular pure-PRP injection in KOA patient

  2022cites this paper
• Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource

  2022cites this paper
• Associations Between Physical Activity, Self-reported Joint Function, and Molecular Biomarkers in Working Age Individuals With Hip and/or Knee Osteoarthritis

  2022cites this paper
• A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative.

  2021cites this paper
• Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression

  2021cites this paper
• Biomarkers of joint metabolism and bone mineral density are associated with early knee osteoarthritis in premenopausal females

  2021cites this paper
• Soluble biological markers in osteoarthritis

  2021cites this paper
• How does hip osteoarthritis differ from knee osteoarthritis?

  2021cites this paper
• Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers

  2021cites this paper
• The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland

  2021cites this paper
• Clinical relevance of biochemical and metabolic changes in osteoarthritis.

  2021cites this paper
• Setting up distinctive outcome measures for each osteoarthritis phenotype

  2020cites this paper
• Can urinary CTX-II be a biomarker for knee osteoarthritis?

  2020cites this paper
• Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update

  2020cites this paper
• A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

  2020cites this paper
• Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis

  2020cites this paper
• Biochemical Markers of Connective Tissue in the Laboratory Diagnosis of Orthopedic Human Diseases

  2020cites this paper
• Pain characteristics and biomarkers in treatment approaches for osteoarthritis pain.

  2020cites this paper
• Disturbances in Metabolic Pathways and the Identification of a Potential Biomarker Panel for Early Cartilage Degeneration in a Rabbit Anterior Cruciate Ligament Transection Model

  2020cites this paper
• Serological CTX-II does not measure the same as urinary CTX-II

  2020cites this paper
• The cartilage degradation marker, urinary CTX-II, is associated with the risk of incident total joint replacement in postmenopausal women. A 18 year evaluation of the OFELY prospective cohort.

  2020cites this paper
• Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review

  2020cites this paper
• Correlation Analysis of C‐terminal telopeptide of collagen type II and Interleukin‐1β for Early Diagnosis of Knee Osteoarthritis

  2019cites this paper
• Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

  2019cites this paper
• GPDPLQ1237—A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

  2019cites this paper
• COMPARISON OF PATELLA ALIGNMENT AND CARTILAGE BIOMARKERS IN YOUNG ADULT FEMALES WITH AND WITHOUT PATELLOFEMORAL PAIN: A PILOT STUDY.

  2019cites this paper
• Computational Methods for the Discovery of Metabolic Markers of Complex Traits

  2019cites this paper
• Predicting Incident Radiographic Knee Osteoarthritis in Middle‐Aged Women Within Four Years: The Importance of Knee‐Level Prognostic Factors

  2019cites this paper
• Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative

  2019cites this paper
• Predicting incident radiographic knee osteoarthritis in middle-aged women within 4 years

  2019cites this paper
• Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women

  2018cites this paper
• Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis

  2018cites this paper
• Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women

  2018cites this paper
• C-Terminal Cross-Linked Telopeptides of Type II Collagen as Biomarker for Radiological Knee Osteoarthritis: A Meta-Analysis

  2018cites this paper
• Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

  2018cites this paper
• Possible association between circulating CTRP3 and knee osteoarthritis in postmenopausal women

  2018cites this paper
• Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial.

  2018cites this paper
• Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility

  2018cites this paper
• Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis: a systematic review and metaanalysis of randomized controlled trials

  2018cites this paper
• Knee pain and related health in the community study (KPIC): a cohort study protocol

  2017cites this paper
• Biomarkers for Diagnosis of Osteoarthritis

  2017cites this paper
• Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

  2017cites this paper
• Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development.

  2017cites this paper
• Beneficial effects of natural eggshell membrane (NEM) on multiple indices of arthritis in collagen-induced arthritic rats

  2017cites this paper
• Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy

  2017cites this paper
• Effectiveness of NEM® brand eggshell membrane in the treatment of suboptimal joint function in dogs: a multicenter, randomized, double-blind, placebo-controlled study

  2016cites this paper
• Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint

  2016cites this paper
• Лабораторные тесты в доклинической диагностике остеоартроза. Аналитический обзор

  2016cites this paper
• Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

  2016influential citation
• Synovium and cartilage biomarkers in hemophilic arthropathy

  2016cites this paper
• Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study

  2016cites this paper
• Laboratory tests in preclinical diagnosis of osteoarthrosis. An analytical review

  2016cites this paper
• Novi koncepti u patofiziologiji i liječenju osteoartritisa

  2016cites this paper
• Biomarkers in Osteoarthritis: Value of Proteomics

  2016cites this paper
• Etude de l'interaction entre 14-3-3 epsilon et CD13/APN dans la communication os/cartilage au cours de l'arthrose

  2016cites this paper
• Bone Biomarkers Related to Osteoarthritis

  2016cites this paper
• Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.

  2016cites this paper
• Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients.

  2016cites this paper
• Effect of Mud-Bath Therapy on Serum Biomarkers in Patients with Knee Osteoarthritis: Results from a Randomized Controlled Trial.

  2016cites this paper
• In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage

  2015cites this paper
• Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model.

  2015cites this paper
• Osteocartilaginous metabolic markers change over a 3-week stage race in pro-cyclists

  2015cites this paper
• Knee pain, knee injury, knee osteoarthritis & work.

  2015cites this paper
• The Rotterdam Study: 2016 objectives and design update

  2015cites this paper
• Efficacy of an equine joint supplement, and the synergistic effect of its active ingredients (chelated trace minerals and natural eggshell membrane), as demonstrated in equine, swine, and an osteoarthritis rat model

  2015cites this paper
• Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

  2015influential citation
• Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review.

  2015cites this paper
• OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hip osteoarthritis.

  2015cites this paper
• Meta-analysis identi fi es loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide signi fi cance

  2014cites this paper
• Inflammation in Equine Articular Cartilage The Effect of Cytokines in Chondrocyte Pellets and Explants: Two in vitro Models

  2014cites this paper
• EVALUATION OF A NUTRACEUTICAL JOINT SUPPLEMENT IN CAMELS { Camelus species)

  2014cites this paper
• ОСОБЕННОСТИ МЕТАБОЛИЗМА МЕЖКЛЕТОЧНОГО ВЕЩЕСТВА У ПАЦИЕНТОК С ОСТЕОАРТРИТОМ И ДИСПЛАЗИЕЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ

  2014cites this paper
• Inflammation in equine articular cartilage

  2014cites this paper
• Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

  2014cites this paper
• Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase.

  2014cites this paper
• Recommendations : Design and conduct of clinical trials for hip osteoarthritis

  year unknowncites this paper