Characterization of Aging-Associated Up-Regulation of Constitutive Nuclear Factor-κB Binding Activity

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Antioxidants & Redox Signaling

• Publication date

  2001-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/152308601750100669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• A Small Region in HMG I(Y) Is Critical for Cooperation with NF-κB on DNA*

  1999cited by this paper
• NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

  1998cited by this paper
• Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms.

  1998cited by this paper
• NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

  1998cited by this paper
• Changes in hepatic DNA binding proteins as a function of age in rats.

  1998cited by this paper
• MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.

  1998cited by this paper
• Amino acid analogs activate NF-kappaB through redox-dependent IkappaB-alpha degradation by the proteasome without apparent IkappaB-alpha phosphorylation. Consequence on HIV-1 long terminal repeat activation.

  1998cited by this paper
• HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

  1998cited by this paper
• Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

  1998cited by this paper
• IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

  1997cited by this paper
• Age-related changes in the regulation of transcription factor NF-κB in rat brain

  1997cited by this paper
• Regulation of apoptosis resistance and ontogeny of age-dependent diseases.

  1997cited by this paper
• IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

  1997cited by this paper
• Constitutive activation of NF-kappa B in an animal model of aging.

  1997cited by this paper
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

  1997cited by this paper
• MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

  1997cited by this paper
• The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

  1997cited by this paper
• Age‐associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity

  1997cited by this paper
• Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.

  1996cited by this paper
• Tyrosine Phosphorylation of I?B-a Activates NF-?B without Proteolytic Degradation of I?B-a

  1996cited by this paper
• Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

  1996cited by this paper
• Antioxidant and redox regulation of gene transcription

  1996cited by this paper
• Differential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences

  1996cited by this paper
• Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle.

  1996cited by this paper
• Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B.

  1996cited by this paper
• Site-specific Tyrosine Phosphorylation of IκBα Negatively Regulates Its Inducible Phosphorylation and Degradation*

  1996cited by this paper
• THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

  1996cited by this paper
• Nuclear Factor B Functions as a Negative Regulator for the Rat Androgen Receptor Gene and NF-B Activity Increases during the Age-dependent Desensitization of the Liver (*)

  1995cited by this paper
• Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

  1995cited by this paper
• STRUCTURE, REGULATION AND FUNCTION OF NF-1d3

  1994influential reference
• The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B.

  1994cited by this paper
• Structure, regulation and function of NF-kappa B.

  1994cited by this paper
• Hundreds of ankyrin‐like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?

  1993cited by this paper
• The IκB proteins: members of a multifunctional family

  1993cited by this paper
• Genomic sequencing.

  1993cited by this paper
• Cellular and molecular mechanisms of aging.

  1993cited by this paper
• Mitochondrial production of pro-oxidants and cellular senescence.

  1992cited by this paper
• The inhibitory ankyrin and activator Rel proteins.

  1992cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper

• Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system

  2025cites this paper
• Tropisetron attenuates D-galactose-induced heart aging in male mice: activation of sirtuin1

  2024cites this paper
• Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

  2023cites this paper
• Ageing and Inflammation: What Happens in Periodontium?

  2023cites this paper
• A review on the potential of underutilized Blackjack (Biden Pilosa) naturally occurring in sub-Saharan Africa

  2022cites this paper
• Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

  2022cites this paper
• Systems approaches to investigate the role of NF-κB signaling in aging

  2022cites this paper
• Signaling pathways and effectors of aging.

  2021cites this paper
• Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats

  2021cites this paper
• Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling.

  2020cites this paper
• SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

  2020cites this paper
• Doxorubicin‐induced senescence through NF‐κB affected by the age of mouse mesenchymal stem cells

  2020cites this paper
• RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis

  2018cites this paper
• Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart.

  2018cites this paper
• On the Evolution Measurement of Somatic Networks by the Changes of Their Robustness and Response Ability in the Aging Process via Microarray Data

  2018cites this paper
• Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice

  2017cites this paper
• Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer’s Disease

  2017cites this paper
• The UPRER: Sensor and Coordinator of Organismal Homeostasis.

  2017cites this paper
• Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells

  2017cites this paper
• Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982.

  2017cites this paper
• Pattern Recognition Receptors, Immune Proteins, and NF-κB Signaling Regulate Behaviors Associated With Aging Phenotypes

  2017cites this paper
• Hepatitis C virus infection

  2017cites this paper
• Chapter 11 – Big Mechanisms of Aging via System Identification and Big Database Mining

  2017cites this paper
• Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?

  2016cites this paper
• Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis

  2016cites this paper
• Influence of aging and growth hormone on different members of the NFkB family and IkB expression in the heart from a murine model of senescence-accelerated aging.

  2016cites this paper
• Reduced NF‐κB activity is observed in dermal fibroblasts from black‐skinned African individuals

  2016cites this paper
• Short report Open Access

  2015cites this paper
• Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

  2015cites this paper
• Naturally occurring hydroxytyrosol derivatives: hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements.

  2015cites this paper
• Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age

  2015cites this paper
• AGEING AND POTENTIAL ANTI-AGING PHYTOCHEMICALS: AN OVERVIEW

  2015cites this paper
• NF-κB activation with aging: characterization and therapeutic inhibition.

  2015cites this paper
• Loss of Nfkb1 leads to early onset aging

  2014cites this paper
• Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

  2014cites this paper
• Melatonin modulates microsomal PGE synthase 1 and NF-E2-related

  2014cites this paper
• Inflammation, advancing age and nutrition

  2014cites this paper
• Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

  2014influential citation
• Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

  2014cites this paper
• Melatonin modulates microsomal PGE synthase 1 and NF‐E2‐related factor‐2‐regulated antioxidant enzyme expression in LPS‐induced murine peritoneal macrophages

  2014cites this paper
• Resveratrol As Anti-Aging Therapy for Age-Related Bone Loss

  2014cites this paper
• Exercice physique, marqueurs antioxydants et peroxydation lipidique : effets de l'âge et du niveau d'aptitude physique

  2014cites this paper
• SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor‐κB Signaling Pathway

  2014cites this paper
• Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process.

  2013cites this paper
• Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes

  2013cites this paper
• Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

  2013cites this paper
• THE EFFECTS OF AGE ON MUSCLE LOSS AND TISSUE-SPECIFIC LEVELS OF NF-ĸB AND SIRT6 PROTEINS IN RATS

  2013cites this paper
• Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin

  2013cites this paper
• On the Increase in Network Robustness and Decrease in Network Response Ability during the Aging Process: A Systems Biology Approach via Microarray Data

  2013cites this paper
• The effects of aging on muscle loss and tissue-specific levels of NF-κB and SIRT6 proteins in rats

  2013cites this paper
• NF-κB controls Il2 and Csf2 expression during T cell development and activation process

  2013cites this paper
• Identification and characterization of senescence-associated microRNAs in a mouse model of the XFE progeroid syndrome

  2013cites this paper
• Silent information regulator (Sir)T1 inhibits NF‐κB signaling to maintain normal skeletal remodeling

  2013cites this paper
• Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

  2012cites this paper
• The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

  2012cites this paper
• Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

  2012cites this paper
• AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network.

  2012cites this paper
• Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide

  2012cites this paper
• Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model.

  2011cites this paper
• Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice.

  2011cites this paper
• Effect of Growth Hormone Treatment on Pancreatic Inflammation, Oxidative Stress, and Apoptosis Related to Aging in SAMP8 Mice

  2011cites this paper
• Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process.

  2010cites this paper
• Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation.

  2010cites this paper
• Stress in Aging – Its Importance and Biological Implications in NF-κ B Signaling

  2010influential citation
• Nitrosative Stress in Aging - Its Importance and Biological Implications in NF-κB Signaling

  2010cites this paper
• Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging

  2010influential citation
• Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production.

  2010cites this paper
• Ageing, telomeres, senescence, and liver injury.

  2010cites this paper
• Perspective: proteomic approach to detect biomarkers of human growth hormone.

  2009cites this paper
• Diet-induced obesity increases NF-κB signaling in reporter mice

  2009cites this paper
• NF-κB Signaling in the Aging Process

  2009influential citation
• Effects of Exercise on Cyclooxygenase‐2 Expression and Nuclear Factor‐κB DNA Binding in Human Peripheral Blood Mononuclear Cells

  2009cites this paper
• Senescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB

  2009cites this paper
• Aging and inflammation: etiological culprits of cancer.

  2009cites this paper
• Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

  2008cites this paper
• Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro‐inflammatory damage

  2008cites this paper
• Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1

  2008cites this paper
• SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?

  2008cites this paper
• Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging.

  2008cites this paper
• Increased mitochondrial H2O2 production promotes endothelial NF- B activation in aged rat arteries

  2007cites this paper
• Age alters cerebrovascular inflammation and effects of estrogen.

  2007cites this paper
• Increased mitochondrial H2O2 production promotes endothelial NF-κB activation in aged rat arteries

  2007cites this paper
• Inhibitory effect of peroxiredoxin II (Prx II) on Ras–ERK–NFκB pathway in mouse embryonic fibroblast (MEF) senescence

  2006cites this paper
• Age-related changes in liver structure and function: Implications for disease ?

  2005cites this paper
• The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats.

  2005cites this paper
• Exercise training reverses age-induced inducible nitric oxide synthase upregulation

  2005cites this paper
• Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells.

  2005cites this paper
• Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.

  2005cites this paper
• Increased phosphorylation and decreased level of IκBα during aging in rat liver

  2005cites this paper
• Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells

  2005cites this paper
• Age‐associated increases in oxidative stress and nuclear transcription factor κB activation are attenuated in rat liver by regular exercise

  2004cites this paper
• Regulation of microglial inflammatory response by sodium butyrate and short‐chain fatty acids

  2004cites this paper
• Inhibition of NF-κB by ZAS3, a zinc-finger protein that also binds to the κB motif

  2003cites this paper
• Regulation of microglial inflammatory response by histone deacetylase inhibitors

  2003cites this paper
• Involvement of Rel/NF-κB transcription factors in senescence

  2003cites this paper
• Growing old with nuclear factor–κB

  2002cites this paper
• Chapter 5 – NF-κB Function in Inflammation, Cellular Stress and Disease

  2002cites this paper
• Alpha-lipoic acid modulates NF-κB activity in human monocytic cells by direct interaction with DNA

  2002cites this paper
• Anti-Aging Medicine LiteratureWatch

  2001cites this paper