Macrophage activation syndrome: I/II

Abstract Macrophage activation syndrome (MAS) is a potentially fatal systemic disorder which results from uncontrolled activation and proliferation of T cells and excessive activation of macrophages. It is a distinct clinicopathologic entity that occurs in different haemophagocytic syndromes (HSs). Primary haemophagocytic lymphohistiocytosis (HLH) is recognized to have an immunogenetic basis, but the secondary HS (also referred to as MAS) occurs in a number of autoimmune disorders including systemic onset juvenile idiopathic arthritis, SLE, adult onset Still's disease and other disorders. In first of the two part series, the aetiology, molecular pathogenesis and diagnostic features will be enunciated. The second part will deal with clinical features and management issues.

• Publication year

  2009

• Venue

  Indian Journal of Rheumatology

• Publication date

  2009-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1177/0973369820090305
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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