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Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis).

Mauriclécio Franco Ponte,T. S. S. Targino,Matheus Alves de Lima Mota,José Saul Peixoto Landim,T. Ribeiro,F. P. Soares,Márcio Roberto Pinho Pereira,S. L. Silva,S. F. R. Silva

Published 2012 in Acta Cirurgica Brasileira

ABSTRACT

PURPOSE To evaluate the antitumor activity of alcoholic extracts of green tea (Camella sinensis). METHODS Four groups of six Wistar rats were inoculated intramuscularly with 10(6) Walker tumor cells/mL. During 10 days, the animals received by gavage either 0.9% saline solution (Group I; negative control), solution containing 20 mg/Kg of tamoxifen (Group II; positive control), solution containing 0.07 g/Kg alcoholic extract of C. sinensis (Group III), or solution containing 0.14 g/Kg alcoholic extract of C. sinensis (Group IV). Following euthanasia on the tenth day, the tumor, liver, kidneys and spleen were excised and weighed, and tumor volume and tumor growth inhibition were quantified. RESULTS The average weight of the animals was greater in Group IV than in Group II (p=0.0107). Tumor weight was smaller in Group IV than in Group I (p=0.0062), but did not differ from Group II. Tumor volume was smaller in Groups II and IV than in Group I (p=0.0131). Tumor growth inhibition was observed in Groups II (44.67% ± 32.47), III (16.83% ± 53.02) and IV (66.4% ± 25.82) (p>0.05). The groups did not differ with regard to the weight of the excised organs. CONCLUSION Alcoholic extracts of green tea have antitumor activity.

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