Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway

Calcitriol, the bioactive metabolite of vitamin D, was reported to inhibit HCV production in a synergistic fashion with interferon, a treatment in vitro. Our previous study established that miR-130a inhibits HCV replication by restoring the host innate immune response. We aimed to determine whether there is additive inhibitory effect of calcitriol and miR-130a on HCV replication. Here we showed that calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems. Intriguingly, this potentiating effect of calcitriol on miR-130a was not through upregulating the expression of cellular miR-130a or through increasing the miR-130a-mediated IFNα/β production. All these findings may contribute to the development of novel anti-HCV therapeutic strategies although the antiviral mechanism needs to be further investigated.

• Publication year

  2015

• Venue

  Mediators of Inflammation

• Publication date

  2015-04-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2015/508989PMID 26060358PMCID 4427768
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitamin-D

  2020cited by this paper
• Vitamin D Receptor and Jak–STAT Signaling Crosstalk Results in Calcitriol-Mediated Increase of Hepatocellular Response to IFN-α

  2014cited by this paper
• MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3.

  2014cited by this paper
• Impaired Expression of Type I and Type II Interferon Receptors in HCV-Associated Chronic Liver Disease and Liver Cirrhosis

  2014cited by this paper
• MicroRNA‐130a inhibits HCV replication by restoring the innate immune response

  2014influential reference
• HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1

  2013cited by this paper
• Simultaneous determination of vitamins D2 and D3 by electrospray ionization LC/MS/MS in infant formula and adult nutritionals: First Action 2012.11.

  2013cited by this paper
• Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection

  2012cited by this paper
• 25‐hydroxyvitamin D3 suppresses hepatitis C virus production

  2012cited by this paper
• An update on vitamin D and human immunity

  2012cited by this paper
• Vitamin D: An innate antiviral agent suppressing hepatitis C virus in human hepatocytes

  2011influential reference
• Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naïve patients.

  2011cited by this paper
• Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C

  2011cited by this paper
• Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon‐based therapy in genotype 1 chronic hepatitis C

  2010cited by this paper
• Vitamin D controls T cell antigen receptor signaling and activation of human T cells

  2010cited by this paper
• Targeting microRNA-122 to Treat Hepatitis C Virus Infection

  2010cited by this paper
• Noncalcemic actions of vitamin D receptor ligands.

  2005cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• Vitamin D

  1928cited by this paper

• Combating Bacterial Infections with Vitamin D-Induced Antimicrobial Peptides.

  2026cites this paper
• Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line

  2025cites this paper
• Insights into the role of vitamin D in targeting the culprits of non-alcoholic fatty liver disease.

  2023cites this paper
• Vitamin D modulates inflammatory response of DENV-2-infected macrophages by inhibiting the expression of inflammatory-liked miRNAs

  2022cites this paper
• NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways

  2021cites this paper
• The Effect of Vitamin D on Anti-HIV microRNAs and HIV Replication in Vitro Model

  2020cites this paper
• About antiviral effects of vitamin D

  2020cites this paper
• [Vitamin D down-regulates microRNA-21 expression to promote human placental trophoblast cell migration and invasion in vitro].

  2019cites this paper
• Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation

  2018cites this paper
• MicroRNA-130a regulates both HCV and HBV replication through a central metabolic pathway

  2018cites this paper
• MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway

  2018cites this paper
• Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control.

  2017cites this paper
• Vitamin D in Standard HCV Regimen (PEG-Interferon Plus Ribavirin), Its Effect on the Early Virologic Response Rate: A Clinical Trial

  2016cites this paper