Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Developmental Cell

• Publication date

  2015-10-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.devcel.2015.09.009PMID 26460946PMCID PMC4615609
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasticity within stem cell hierarchies in mammalian epithelia.

  2015cited by this paper
• A synthetic niche for nephron progenitor cells.

  2015cited by this paper
• Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions

  2014cited by this paper
• In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

  2014cited by this paper
• Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.

  2014cited by this paper
• Global quantification of tissue dynamics in the developing mouse kidney.

  2014cited by this paper
• Nephron progenitor cells: shifting the balance of self-renewal and differentiation.

  2014cited by this paper
• Haematopoietic stem cells require a highly regulated protein synthesis rate

  2014cited by this paper
• Single cell dissection of early kidney development: multilineage priming

  2014cited by this paper
• mTORC1 signaling controls multiple steps in ribosome biogenesis.

  2014cited by this paper
• The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment.

  2014cited by this paper
• Role for compartmentalization in nephron progenitor differentiation

  2013cited by this paper
• Rapalogs and mTOR inhibitors as anti-aging therapeutics.

  2013cited by this paper
• Mammalian kidney development: principles, progress, and projections.

  2012cited by this paper
• Optimality in the development of intestinal crypts.

  2012cited by this paper
• Differential analysis of gene regulation at transcript resolution with RNA-seq

  2012cited by this paper
• Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  2012cited by this paper
• FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

  2012cited by this paper
• Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria.

  2012cited by this paper
• Human nephron number: implications for health and disease

  2011cited by this paper
• Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production

  2011cited by this paper
• Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

  2011cited by this paper
• Regulation of kidney development by histone deacetylases

  2011cited by this paper
• Nephron formation adopts a novel spatial topology at cessation of nephrogenesis.

  2011cited by this paper
• Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation*

  2011cited by this paper
• Accelerated maturation and abnormal morphology in the preterm neonatal kidney.

  2011cited by this paper
• Defining and redefining the nephron progenitor population

  2011cited by this paper
• Organ culture and immunostaining of mouse embryonic kidneys.

  2011cited by this paper
• GDNF/Ret signaling and renal branching morphogenesis

  2010cited by this paper
• Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

  2010cited by this paper
• mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

  2009cited by this paper
• High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.

  2009cited by this paper
• Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.

  2008cited by this paper
• Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.

  2008cited by this paper
• Interpretation of birth weight data: a note of caution.

  2008cited by this paper
• Hypertension and microalbuminuria in children with congenital solitary kidneys

  2008cited by this paper
• Intrinsic epithelial cells repair the kidney after injury.

  2008cited by this paper
• Cessation of renal morphogenesis in mice.

  2007cited by this paper
• Molecular insights into segmentation along the proximal-distal axis of the nephron.

  2007cited by this paper
• Reduced nephron number and glomerulomegaly in Australian Aborigines: a group at high risk for renal disease and hypertension.

  2006cited by this paper
• A role for fibronectin‐leucine‐rich transmembrane cell‐surface proteins in homotypic cell adhesion

  2006cited by this paper
• Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.

  2005cited by this paper
• The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling

  2004cited by this paper
• Histomorphometric Analysis of Postnatal Glomerulogenesis in Extremely Preterm Infants

  2004cited by this paper
• Nephron number in patients with primary hypertension.

  2003cited by this paper
• CLUSFAVOR 5.0: hierarchical cluster and principal-component analysis of microarray-based transcriptional profiles

  2002cited by this paper
• Effective dimensionality of large-scale expression data using principal component analysis.

  2002cited by this paper
• Block principal component analysis with application to gene microarray data classification

  2002cited by this paper
• Growth in utero and blood pressure levels in the next generation

  2000cited by this paper
• Low birth weights contribute to high rates of early-onset chronic renal failure in the Southeastern United States.

  2000cited by this paper
• Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation.

  1999cited by this paper
• Architectural patterns in branching morphogenesis in the kidney.

  1998cited by this paper
• Age-dependent specification of the corticocortical connections of cerebral grafts

  1995cited by this paper
• The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype.

  1994cited by this paper
• Community effects and related phenomena in development.

  1993cited by this paper
• Genetic analysis of leaf development in cotton

  1991cited by this paper
• The early commitment of fetal neurons to the limbic cortex

  1991cited by this paper
• Potential of visual cortex to develop an array of functional units unique to somatosensory cortex

  1991cited by this paper
• Selective elimination of axons extended by developing cortical neurons is dependent on regional locale: experiments utilizing fetal cortical transplants

  1989cited by this paper
• A community effect in animal development

  1988cited by this paper

• Screening Hub Genes of Ferroptosis in Pb‐Induced Acute Kidney Injury Based on GEO Database Bioinformatics and Experimental Validation

  2025cites this paper
• Bridging the gap of late-gestation nephrogenesis using a non-human primate model

  2025cites this paper
• Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids

  2025cites this paper
• Kidney development at a glance: metabolic regulation of renal progenitor cells.

  2025cites this paper
• Impact of preterm birth on kidney health and development

  2024cites this paper
• Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula

  2024cites this paper
• Progress and Challenges of Water-soluble NIR-II Organic Fluorophores for Fluorescence Imaging in vivo

  2024cites this paper
• Generation of human-pig chimeric renal organoids using iPSC technology

  2024cites this paper
• Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation.

  2023cites this paper
• Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease.

  2023cites this paper
• Single-cell transcriptomics: A new tool for studying diabetic kidney disease

  2023cites this paper
• Tubule jamming in the developing mouse kidney creates cyclical mechanical stresses in nephron-forming niches

  2023cites this paper
• Characterizing post-branching nephrogenesis in the neonatal rabbit

  2023cites this paper
• Generation of chimeric kidneys using progenitor cell replacement: Oshima Award Address 2021

  2022cites this paper
• Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

  2022cites this paper
• Regulation of nephron progenitor cell lifespan and nephron endowment

  2022cites this paper
• Growth control of the kidney.

  2022cites this paper
• NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications.

  2022cites this paper
• Principles of human and mouse nephron development

  2022cites this paper
• Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes

  2022cites this paper
• Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

  2021cites this paper
• Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

  2021cites this paper
• Chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development

  2021influential citation
• Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney

  2021cites this paper
• The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis

  2021cites this paper
• DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets

  2021cites this paper
• Computational Modelling of Nephron Progenitor Cell Movement and Aggregation During Kidney Organogenesis

  2021cites this paper
• Pre-natal Development of the Kidneys and Urinary Tract

  2021cites this paper
• Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

  2021cites this paper
• Development of the metanephric kidney.

  2021cites this paper
• Regrow or Repair: An Update on Potential Regenerative Therapies for the Kidney

  2021cites this paper
• Computational Modelling of Nephron Progenitor Cell Movement and Aggregation during Kidney Organogenesis

  2020influential citation
• Age-Dependent Changes in the Progenitor Translatome Coordinated in part by Tsc1 Increase Perception of Signaling Inputs to End Nephrogenesis

  2020cites this paper
• mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases

  2020cites this paper
• R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

  2020cites this paper
• Stem cells in kidney development and regeneration

  2020cites this paper
• Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF

  2020cites this paper
• Metabolic programming of nephron progenitor cell fate

  2020influential citation
• Molecular detection of maturation stages in the developing kidney.

  2020cites this paper
• Returning to kidney development to deliver synthetic kidneys.

  2020cites this paper
• Epigenetic regulation of kidney progenitor cells

  2020cites this paper
• Defining the dynamic chromatin landscape of mouse nephron progenitors

  2019cites this paper
• Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.

  2019cites this paper
• Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors

  2019cites this paper
• Human kidney organoids: progress and remaining challenges

  2019cites this paper
• Defining the dynamic chromatin landscape of nephron progenitors

  2019cites this paper
• Renal Development and Molecular Pathogenesis of Renal Dysplasia

  2019cites this paper
• Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells.

  2019cites this paper
• Nephron progenitor cell commitment: Striking the right balance.

  2019cites this paper
• The Role of Hypoxia in Metabolism and Nephron Development

  2019cites this paper
• Paracrine and autocrine R-spondin signalling is essential for the maintenance and differentiation of renal stem cells

  2019cites this paper
• MAPK/ERK Signaling in Regulation of Renal Differentiation

  2019cites this paper
• A brief review of single-cell transcriptomic technologies.

  2018cites this paper
• Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

  2018cites this paper
• Evolution and Kidney Development: A Rosetta Stone for Nephrology.

  2018cites this paper
• The Era of Human Developmental Nephrology.

  2018cites this paper
• Geometry of Gene Expression Space of Wilms' Tumors From Human Patients12

  2018cites this paper
• Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

  2018cites this paper
• Kidney Nephron Determination.

  2018cites this paper
• A cluster robustness score for identifying cell subpopulations in single cell gene expression datasets from heterogeneous tissues and tumors

  2018cites this paper
• Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

  2018cites this paper
• Regulation of Renal Differentiation by Trophic Factors

  2018cites this paper
• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

  2018cites this paper
• Tackling Tsc1 to Promote Nephrogenesis

  2018cites this paper
• Nephron progenitor commitment is a stochastic process influenced by cell migration

  2018cites this paper
• A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation

  2017influential citation
• Kidney Development in the Mammal

  2017cites this paper
• Recapitulating Development to Generate Kidney Organoid Cultures

  2017cites this paper
• Growth Factor Regulation in the Nephrogenic Zone of the Developing Kidney.

  2017cites this paper
• Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

  2017cites this paper
• New Insights into Fuel Choices of Nephron Progenitor Cells.

  2017cites this paper
• Extracellular Vesicles in Preeclampsia: Evolving Contributors to Proteinuria.

  2017cites this paper
• Prorenin receptor in kidney development

  2017cites this paper
• Effects of Maternal Protein Restriction on Nephrogenesis and Adult and Aging Kidney

  2017cites this paper
• Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system

  2017cites this paper
• PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells

  2017cites this paper
• Does Renal Repair Recapitulate Kidney Development?

  2017cites this paper
• New Insights into Podocyte Biology in Glomerular Health and Disease.

  2017cites this paper
• Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development

  2017cites this paper
• High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidney

  2017cites this paper
• Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.

  2017cites this paper
• Early Kidney Specification and Its Recapitulation by Pluripotent Stem Cells

  2017cites this paper
• Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells.

  2016influential citation
• Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

  2016cites this paper
• Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells.

  2016cites this paper
• Making new kidneys: On the road from science fiction to science fact

  2016cites this paper
• Renal dysplasia in the neonate

  2016cites this paper
• Brain-derived neurotrophic factor: a mediator of inflammation-associated neurogenesis in Alzheimer’s disease

  2016cites this paper
• The contribution of branching morphogenesis to kidney development and disease

  2016cites this paper
• Stem cells and renal development in 2015: Advances in generating and maintaining nephron progenitors

  2016cites this paper
• Stem cells: Young nephron progenitors might extend the lifespan of old progenitors

  2015cites this paper
• The Life Cycle of the Nephron Progenitor.

  2015influential citation