What causes elevated B-type natriuretic peptide in patients without heart failure?

Background. Hypertension (HTN) and high serum cholesterol (HC) level are often combined in the same subject where they contribute to the overall cardiovascular risk proflle. HC is associated with a” impaired vasodilatory capacity and a” overexpression of vascular angiotensin II receptors, which can contribute to the develpment of HTN. Aim of the present study was to investigate the role of HC, if any, in the development of HTN in the Brisighella Heart Study. Methods. 1230 “ormotensive subjects (SBP/DBPcl40/90 mmHg) enrolled in the Brislghella Heart Study in 1972 have been divided according to total serum cholesterol (TChol) tertiles and followed for 12 years to evaluate the proportion of patients developing HTN defined as SBP and/or DBP>l40/90 mmHg and/or therapy for HTN. Results. After adjustment for the main counfondlng factors (family history of HTN, age, BMI, sex, diabetes) the rate of HTN was significantly increased in subjects with T-Chol z 239 mg/dl both after 8 (1980) and 12 (1984) years of follow-up (‘p<O.OOi YS. other subgroups). The rate of development of HTN was enhanced in the two older subgroups of subjects (30-59 and z-59 years). Conclusion. These data suggest that HC could substantially contribute to the development of HTN and strongly support the wide role of lipid lowering drugs and particulary statins in the pnmary prevention of cardiovascular disease.

• Publication year

  2003

• Venue

  Journal of the American College of Cardiology

• Publication date

  2003-03-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0735-1097(03)82308-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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• No concepts are published for this paper.

• No references are available for this paper.

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