Functional Analysis of a p21WAF1,CIP1,SDI1 Mutant (Arg94 → Trp) Identified in a Human Breast Carcinoma

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Biological Chemistry

• Publication date

  1996-06-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.271.26.15782PMID 8663132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

  2019cited by this paper
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  1995cited by this paper
• A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma.

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• Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

  1995cited by this paper
• Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.

  1995cited by this paper
• The C-terminal Region of p21 Is Involved in Proliferating Cell Nuclear Antigen Binding but Does Not Appear to Be Required for Growth Inhibition (*)

  1995cited by this paper
• p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

  1995cited by this paper
• p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

  1995cited by this paper
• Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

  1995cited by this paper
• Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.

  1995cited by this paper
• Role of the cyclin-dependent kinase inhibitors in the development of cancer.

  1995cited by this paper
• Inhibitors of mammalian G1 cyclin-dependent kinases.

  1995cited by this paper
• A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.

  1995cited by this paper
• Cyclins and cyclin-dependent kinases: a biochemical view.

  1995cited by this paper
• Radiation-induced cell cycle arrest compromised by p21 deficiency

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• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• A novel form of Epstein-Barr virus latency in normal B cells in vivo.

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• Principles of CDK regulation

  1995cited by this paper
• Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

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• Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

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  1994cited by this paper
• Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

  1994cited by this paper
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• The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

  1994cited by this paper
• Absence of WAF1 mutations in a variety of human malignancies.

  1994cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• p21-containing cyclin kinases exist in both active and inactive states.

  1994cited by this paper
• Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

  1994cited by this paper
• Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).

  1994cited by this paper
• Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

  1994cited by this paper
• Induction of p21 (WAF-1/CIP1) during differentiation.

  1994cited by this paper
• Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair.

  1994cited by this paper
• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

  1994cited by this paper
• A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.

  1994cited by this paper
• Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle.

  1994cited by this paper
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• p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

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  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

  1993influential reference
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993influential reference
• A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level

  1993cited by this paper
• The p53 tumor suppressor protein, a modulator of cell proliferation.

  1992cited by this paper
• p53 function and dysfunction.

  1992cited by this paper
• Blood.

  1989cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977influential reference

• Prognostic Significance of P21 Protein in Breast Cancer

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• Die Untersuchung des antiapoptotischen Effekts von TAT-p21 bei der Doxorubicin-induzierten Kardiomyopathie in der Maus

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• Nouvelles fonctions de p21Cip1 dans la dynamique cytosquelettique des cellules épithéliales mammaires humaines

  2010cites this paper
• 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis

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• Human Papillomavirus E 7 Oncoprotein Overrides the Tumor Suppressor Activity of p 21 Cip 1 in Cervical Carcinogenesis

  2009cites this paper
• Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.

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• p21 in cancer: intricate networks and multiple activities

  2009cites this paper
• Tamoxifen-stimulated growth of breast cancer due to p21 loss

  2008cites this paper
• p21 and p27: roles in carcinogenesis and drug resistance

  2008cites this paper
• Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10).

  2008cites this paper
• The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

  2007cites this paper
• The p 21 Waf 1 pathway is involved in blocking leukemogenesis by the t ( 8 ; 21 ) fusion protein AML 1-ETO

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• Cell cycle and cancer

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