SIMULTANEOUS DETERMINATION OF EIGHT PDE5-IS POTENTIALLY ADULTERATED IN HERBAL DIETARY SUPPLEMENTS WITH TLC AND HPLC-PDA-MS METHODS

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Liquid Chromatography & Related Technologies

• Publication date

  2010-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1080/10826076.2010.488979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Liquid chromatography/tandem mass spectrometry method for the simultaneous determination of vardenafil and its major metabolite, N-desethylvardenafil, in human plasma: application to a pharmacokinetic study.

  2009cited by this paper
• Isolation and structural elucidation of cyclopentynafil and N-octylnortadalafil found in a dietary supplement.

  2009cited by this paper
• Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry.

  2009influential reference
• Modified Local Straight-Line Screening to Detect Synthetic Drugs in Adulterated Herbal Medicines

  2009cited by this paper
• Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs.

  2009cited by this paper
• Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.

  2008cited by this paper
• Designer drugs in herbal aphrodisiacs.

  2008cited by this paper
• Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements.

  2008cited by this paper
• Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac.

  2008cited by this paper
• Study on PDE_5 Inhibitors and Its Unknown Derivatives in Traditional Chinese Medicine and Health Food Discovered

  2008cited by this paper
• Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria.

  2008cited by this paper
• Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.

  2008cited by this paper
• Identification of a novel vardenafil analogue in herbal product.

  2008cited by this paper
• Quantitative analysis of sildenafil and desmethylsildenafil in human serum by liquid chromatography-mass spectrometry with minimal sample pretreatment.

  2008cited by this paper
• Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement.

  2007cited by this paper
• A study of western pharmaceuticals contained within samples of Chinese herbal/patent medicines collected from New York City's Chinatown.

  2007cited by this paper
• Structure determination of new analogues of vardenafil and sildenafil in dietary supplements

  2007cited by this paper
• Analogues of erectile dysfunction drugs: an under-recognised threat.

  2007cited by this paper
• Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement.

  2007cited by this paper
• Solid phase extraction and liquid chromatographic determination of sildenafil and N-demethylsildenafil in rat serum with basic mobile phase.

  2006cited by this paper
• Determination of Sildenafil, Tadalafil, and Vardenafil in Tablets and Adulterated Herbal Products by ESI‐MS‐MS

  2006cited by this paper
• Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product

  2006cited by this paper
• Electrospray tandem mass spectrometric investigations of tadalafil and its analogue.

  2006cited by this paper
• Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices.

  2006cited by this paper
• Detection of Sildenafil Analogues in Herbal Products for Erectile Dysfunction

  2006cited by this paper
• Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies.

  2006cited by this paper
• Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography-electrospray ionization tandem mass spectrometry.

  2006cited by this paper
• Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS.

  2006cited by this paper
• Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement

  2006cited by this paper
• Use of liquid chromatography-mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a "natural" herbal dietary supplement.

  2006cited by this paper
• Simultaneous determination of sildenafil, vardenafil and tadalafil as forbidden components in natural dietary supplements for male sexual potency by high-performance liquid chromatography-electrospray ionization mass spectrometry.

  2005influential reference
• Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors.

  2005cited by this paper
• The Global Threat of Counterfeit Drugs: Why Industry and Governments Must Communicate the Dangers

  2005cited by this paper
• Structure elucidation of sildenafil analogues in herbal products

  2004cited by this paper
• Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV.

  2004cited by this paper
• Structure determination of a sildenafil analogue contained in commercial herb drinks

  2004cited by this paper
• Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction

  2003cited by this paper
• Sensitive liquid chromatography assay with ultraviolet detection for a new phosphodiesterase V inhibitor, DA-8159, in human plasma and urine.

  2003cited by this paper
• HPLC-MS for the determination of sildenafil citrate (Viagra) in biological fluids. Application to the salivary excretion of sildenafil after oral intake.

  2003cited by this paper
• Separation and Determination of Synthetic Impurities of Sildenafil (Viagra) by Reversed-Phase High-Performance Liquid Chromatography

  2003cited by this paper
• Development of a liquid chromatographic method for bioanalytical applications with sildenafil.

  2003cited by this paper
• IC351 (tadalafil, Cialis): update on clinical experience

  2002cited by this paper
• Determination of sildenafil citrate and its main metabolite by sample stacking with polarity switching using micellar electrokinetic chromatography.

  2002cited by this paper
• Simultaneous assay of sildenafil and desmethylsildenafil in human plasma using liquid chromatography-tandem mass spectrometry on silica column with aqueous-organic mobile phase.

  2002cited by this paper
• Guidelines on erectile dysfunction.

  2002cited by this paper
• Nose-bleeds after sildenafil (Viagra).

  2002cited by this paper
• Stability indicating RP-LC determination of sildenafil citrate (Viagra) in pure form and in pharmaceutical samples.

  2002cited by this paper
• Simultaneous identification/determination system for phentolamine and sildenafil as adulterants in soft drinks advertising roborant nutrition.

  2002cited by this paper
• Selective phosphodiesterase type 5 inhibition using tadalafil for the treatment of erectile dysfunction

  2002cited by this paper
• [Determination of sildenafil in medicines for erectile dysfunction by capillary electrophoresis].

  2002cited by this paper
• Determination of transdermal sildenafil in nude mouse skin by reversed-phase high-performance liquid chromatography.

  2001cited by this paper
• Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS

  2001cited by this paper
• Development of an assay for the simultaneous determination of sildenafil (Viagra) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high-performance liquid chromatography.

  1997cited by this paper

• Ginseng as Promising Natural Medicine against Infectious Diseases: Therapeutic Targets and Potential Mechanisms.

  2025cites this paper
• Ginseng Adulteration Across Global Markets and Evaluation of Commercial Product Authenticity

  2025cites this paper
• Undeclared phosphodiesterase type 5 inhibitors (PDE5Is) in food supplements on the Croatian market analyzed by liquid chromatography time-of-flight mass spectrometry (LC-QTOF-MS)

  2024cites this paper
• Fluorescence "turn-on" sensing for five PDE5 inhibitors in functional food based on bimetallic nanoclusters.

  2023cites this paper
• IDENTIFICATION AND QUANTIFICATION OF PHOSPHODIESTERASE-5 INHIBITOR AS FALSIFIED IN ‘‘NATURAL’’ MALAYSIAN HERBAL APHRODISIACS SOLD IN SOME BENINESE MARKETS

  2022cites this paper
• A Comprehensive Review on Analytical Techniques for Determination of Sex Stimulants, PDE5 Inhibitors in Different Matrices with Special Focus on the Electroanalytical Methods

  2022influential citation
• HPLC-UV and UPLC-MS/MS methods for the simultaneous analysis of sildenafil, vardenafil, and tadalafil and their counterfeits dapoxetine, paroxetine, citalopram, tramadol, and yohimbine in aphrodisiac products

  2021cites this paper
• A Review of Authenticity and Authentication of Commercial Ginseng Herbal Medicines and Food Supplements

  2021cites this paper
• Fluorescence polarisation for high-throughput screening of adulterated food products via phosphodiesterase 5 (PDE5) inhibition assay.

  2020cites this paper
• Determination of Phosphodiesterase Type 5 Enzyme (PDE-5) Inhibitors and Analogues as Adulterants in Selected Herbal Products using Gas Chromatography–Electron Impact-Mass Spectrometer (GC-EI-MS)

  2020cites this paper
• Screening of Phosphodiesterase-5 Inhibitors and Their Analogs in Dietary Supplements by Liquid Chromatography–Hybrid Ion Trap–Time of Flight Mass Spectrometry

  2020cites this paper
• Fluorescence based immunochromatographic sensor for rapid and sensitive detection of tadalafil and comparison with a gold lateral flow immunoassay.

  2020cites this paper
• Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects.

  2019cites this paper
• Advances in Testing for Adulteration of Food Supplements

  2016cites this paper
• Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A Review.

  2016cites this paper
• Adulterated and Counterfeit Male Enhancement Nutraceuticals and Dietary Supplements Pose a Real Threat to the Management of Erectile Dysfunction: A Global Perspective

  2016influential citation
• Chemical Adulterants in Herbal Medicinal Products: A Review

  2016cites this paper
• Identification and evaluation of fragmentation pathways of PDE-5 inhibitor analogues using LC-QTOF-MS

  2015cites this paper
• SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF VARDENAFIL AND DAPOXETINE HYDROCHLORIDES IN COMBINED DOSAGE FORM

  2015cites this paper
• Analysis of Dietary Supplements

  2015cites this paper
• Capillary electrophoretic methods for the screening and determination of pharmacologic adulterants in herbal‐based pharmaceutical formulations

  2014cites this paper
• Application of a high resolution benchtop quadrupole-Orbitrap mass spectrometry for the rapid screening, confirmation and quantification of illegal adulterated phosphodiesterase-5 inhibitors in herbal medicines and dietary supplements.

  2014cites this paper
• ualitative and quantitative analysis of PDE5 inhibitors in ounterfeit medicines and dietary supplements by HPLC – UV sing sildenafil as a sole reference

  2014cites this paper
• Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.

  2014cites this paper
• Viagra® and Cialis® blister packaging fingerprinting using Fourier transform infrared spectroscopy (FTIR) allied with chemometric methods

  2014cites this paper
• Development and Validation of HPTLC Method for Simultaneous Estimation of Sildenafil Citrate and Dapoxetine Hydrochloride in Combined Dosage Form

  2014cites this paper
• Simultaneous identification, confirmation and quantitation of illegal adulterated antidiabetics in herbal medicines and dietary supplements using high-resolution benchtop quadrupole-Orbitrap mass spectrometry.

  2014cites this paper
• ^#.^t36: TLC of Drugs Used in Obesity and Sexual Dysfunction Treatment

  2013cites this paper
• Fingerprinting of sildenafil citrate and tadalafil tablets in pharmaceutical formulations via X-ray fluorescence (XRF) spectrometry.

  2012cites this paper
• Comparison of sterols and fatty acids in two species of Ganoderma

  2012cites this paper