Molecular mechanisms underlying inflammatory lung diseases in the elderly: Development of a novel therapeutic strategy for acute lung injury and pulmonary fibrosis

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Geriatrics & Gerontology International

• Publication date

  2005-09-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1447-0594.2005.00294.x
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Platelet-Activating Factor Receptor Develops Airway Hyperresponsiveness Independently of Airway Inflammation in a Murine Asthma Model

  2004cited by this paper
• New therapeutic key for cystic fibrosis: a role for lipoxins

  2004cited by this paper
• A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice.

  2003cited by this paper
• Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).

  2002cited by this paper
• Discrete Role for Cytosolic Phospholipase A2α in Platelets

  2002cited by this paper
• A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis

  2002cited by this paper
• Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.

  2002cited by this paper
• Protection from pulmonary fibrosis in leukotriene-deficient mice.

  2002cited by this paper
• Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.

  2001cited by this paper
• Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.

  2000cited by this paper
• Idiopathic pulmonary fibrosis: Diagnosis and treatment: International Consensus Statement

  2000cited by this paper
• Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF.

  2000cited by this paper
• Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2

  2000cited by this paper
• Elevated cytosolic phospholipase A(2) expression and activity in human neutrophils during sepsis.

  2000cited by this paper
• Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice.

  1999cited by this paper
• Predicting gastric contents following trauma: an evaluation of current practice.

  1999cited by this paper
• Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.

  1999cited by this paper
• Cytosolic phospholipase A2 activation is essential for beta 1 and beta 2 integrin-dependent adhesion of human eosinophils.

  1999cited by this paper
• Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor

  1998cited by this paper
• Platelet-activating factor plays a pivotal role in the induction of experimental lung injury.

  1998cited by this paper
• Role of cytosolic phospholipase A2 in allergic response and parturition

  1997cited by this paper
• A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

  1997cited by this paper
• Properties and Regulation of Cytosolic Phospholipase A2 *

  1997cited by this paper
• Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.

  1997cited by this paper
• Biological markers of acute lung injury: prognostic and pathogenetic significance.

  1997cited by this paper
• Prevention of bleomycin-induced pulmonary fibrosis after adenovirus-mediated transfer of the bacterial bleomycin resistance gene.

  1997cited by this paper
• Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet‐activating factor receptor

  1997cited by this paper
• Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

  1996cited by this paper
• A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.

  1996cited by this paper
• A role for the beta2 integrin CD11b in mediating experimental lung injury in mice.

  1996cited by this paper
• Clinical risks for development of the acute respiratory distress syndrome.

  1995cited by this paper
• Platelet-activating factor receptor: gene expression and signal transduction.

  1995cited by this paper
• Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

  1995cited by this paper
• Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.

  1994cited by this paper
• Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.

  1994cited by this paper
• Platelet-activating factor: receptors and signal transduction.

  1993cited by this paper
• Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.

  1993cited by this paper
• cPLA2 is phosphorylated and activated by MAP kinase.

  1993cited by this paper
• The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.

  1992cited by this paper
• Cellular mechanisms of acute lung injury: implications for future treatment in the adult respiratory distress syndrome.

  1992cited by this paper
• Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.

  1992cited by this paper
• A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.

  1991cited by this paper
• Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.

  1991cited by this paper
• Intravenous bolus of prednisolone decreases 15‐hydroxyeicosatetraenoic acid formation in the rat model of acid aspiration

  1991cited by this paper
• Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.

  1991cited by this paper
• Platelet-activating Factor

  1991cited by this paper
• Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

  1991cited by this paper
• Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor.

  1991cited by this paper
• Complications of head injury and their therapy.

  1991cited by this paper
• Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells.

  1990cited by this paper
• Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.

  1987cited by this paper
• Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung.

  1986cited by this paper
• Adult respiratory distress syndrome: risk with common predispositions.

  1983cited by this paper

• No citing papers are available for this paper.