No substantial changes in estrogen receptor and estrogen-related receptor orthologue gene transcription in Marisa cornuarietis exposed to estrogenic chemicals☆☆☆

R. Bannister,N. Beresford,D. Granger,N. Pounds,M. Rand-Weaver,Roger White,S. Jobling,E. Routledge

Published 2013 in Aquatic Toxicology

ABSTRACT

Highlights • ER and ERR transcription levels were unaffected in Marisa cornuarietis exposed to 17β-estradiol or 4-tert-Octylphenol.• The mollusc ER protein interacts with the phytoestrogen genistein in transfected HEK-293 cells.• The mollusc ERR protein interacts weakly with bisphenol-A in transfected HEK-293 cells.• The mollusc ER protein binds to the vertebrate consensus estrogen response element (ERE) sequence.

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