Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study

BackgroundThe purpose of this study was to measure regional contractile function in the normal rat using cardiac cine and tagged cardiovascular magnetic resonance (CMR) during incremental low doses of dobutamine and at rest.MethodsFive rats were investigated for invasive left ventricle pressure measurements and five additional rats were imaged on a clinical 1.5 T MR system using a cine sequence (11–20 phases per cycle, 0.28/0.28/2 mm) and a C-SPAMM tag sequence (18–25 phases per cycle, 0.63/1.79/3 mm, tag spacing 1.25 mm). For each slice, wall thickening (WT) and circumferential strains (CS) were calculated at rest and at stress (2.5, 5 and 10 μg/min/kg of dobutamine).ResultsGood cine and tagged images were obtained in all the rats even at higher heart rate (300–440 bpm). Ejection fraction and left ventricular (LV) end-systolic volume showed significant changes after each dobutamine perfusion dose (p < 0.001). Tagged CMR had the capacity to resolve the CS transmural gradient and showed a significant increase of both WT and CS at stress compared to rest. Intra and interobserver study showed less variability for the tagged technique. In rats in which a LV catheter was placed, dobutamine produced a significant increase of heart rate, LV dP/dtmax and LV pressure significantly already at the lowest infusion dose.ConclusionRobust cardiac cine and tagging CMR measurements can be obtained in the rat under incremental dobutamine stress using a clinical 1.5 T MR scanner.

• Publication year

  2008

• Venue

  Journal of Cardiovascular Magnetic Resonance

• Publication date

  2008-11-03

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1186/1532-429X-10-48PMID 18980685PMCID 2590601
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection

  2008cited by this paper
• Multi-parameter in vivo cardiac magnetic resonance imaging demonstrates normal perfusion reserve despite severely attenuated beta-adrenergic functional response in neuronal nitric oxide synthase knockout mice.

  2007cited by this paper
• High-Resolution Complementary Spatial Modulation of Magnetization (CSPAMM) Rat Heart Tagging on a 1.5 Tesla Clinical Magnetic Resonance System: A Preliminary Feasibility Study

  2007cited by this paper
• MR in mouse models of cardiac disease

  2007cited by this paper
• Extrema Temporal Chaining: A New Method for Computing the 2D-Displacement Field of the Heart from Tagged MRI

  2006cited by this paper
• Optimization of cardiac cine in the rat on a clinical 1.5-T MR system

  2006cited by this paper
• MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men.

  2006cited by this paper
• Cine and tagged magnetic resonance imaging in short-term stunned versus necrotic myocardium

  2005cited by this paper
• Dobutamine stress echocardiography in healthy adult male rats

  2005cited by this paper
• Harmonic phase MR tagging for direct quantification of lagrangian strain in rat hearts after myocardial infarction

  2004cited by this paper
• Current status of cardiac MRI in small animals

  2004cited by this paper
• Time course of right ventricular remodeling in rats with experimental myocardial infarction.

  2003cited by this paper
• Fast, high‐resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system

  2003cited by this paper
• Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats

  2001cited by this paper
• Dobutamine-Stress Magnetic Resonance Microimaging in Mice: Acute Changes of Cardiac Geometry and Function in Normal and Failing Murine Hearts

  2001cited by this paper
• Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium.

  2001cited by this paper
• The cardiac Fas (APO-1/CD95) Receptor/Fas ligand system : relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes.

  2000cited by this paper
• Quantification of left ventricular function with magnetic resonance images acquired in real time

  2000cited by this paper
• MR imaging of the heart in patients after myocardial infarction: effect of increasing intersection gap on measurements of left ventricular volume, ejection fraction, and wall thickness.

  1999cited by this paper
• Effect of dobutamine on regional left ventricular function measured by tagged magnetic resonance imaging in normal subjects.

  1999cited by this paper
• Techniques for high‐speed cardiac magnetic resonance imaging in rats and rabbits

  1997cited by this paper
• Breath-hold dobutamine magnetic resonance myocardial tagging: normal left ventricular response.

  1997cited by this paper
• Cardiac tagging in the rat using a DANTE sequence

  1991cited by this paper
• Journal of Cardiovascular Magnetic Resonance Relationship of Number of Phases per Cardiac Cycle and Accuracy of Measurement of Left Ventricular Volumes, Ejection Fraction, and Mass

  year unknowncited by this paper

• Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats

  2021cites this paper
• Final Degree Project Biomedical Engineering Degree “Scar conducting channel wall thickness characterization to predict arrhythmogenicity during ventricular tachycardia ablation”

  2021cites this paper
• Guidelines for measuring cardiac physiology in mice

  2018cites this paper
• Quantification of Regional Ventricular Wall Motion in Laboratory Animals

  2018cites this paper
• Molecular imaging of inflammation and extracellular matrix remodelling after myocardial infarction

  2017cites this paper
• Quantification of ventricular mechanical dyssynchrony under stress

  2017cites this paper
• Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model.

  2017influential citation
• Introduction to Cardiovascular Magnetic Resonance Imaging

  2017cites this paper
• Clinical Applications of Heart Mechanics with MRI: Part II

  2017cites this paper
• Computational biomechanics in the remodelling rat heart post myocardial infarction

  2016cites this paper
• Limitations and pitfalls in measurements of right ventricular stroke volume in an animal model of right heart failure

  2015cites this paper
• of Cardiovascular Magnetic Resonance 2009

  2015cites this paper
• Small animal cardiovascular MR imaging and spectroscopy.

  2015cites this paper
• Self‐gated cardiac Cine MRI of the rat on a clinical 3 T MRI system

  2015cites this paper
• Quantitative Study of the Effect of Tissue Microstructure on Contraction in a Computational Model of Rat Left Ventricle

  2014influential citation
• Reproducibility of small animal cine and scar cardiac magnetic resonance imaging using a clinical 3.0 tesla system

  2013cites this paper
• Immunohistochemical expression of oncological proliferation markers in the hearts of rats during normal pregnancy.

  2013cites this paper
• Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance

  2013cites this paper
• Quantitative Magnetic Resonance Imaging in experimental and applied clinical research

  2013cites this paper
• Evolution of cardiac and renal impairment detected by high-field cardiovascular magnetic resonance in mice with renal artery stenosis

  2013cites this paper
• Embryonic Stem Cell‐Based Cardiopatches Improve Cardiac Function in Infarcted Rats

  2012cites this paper
• High Time-Resolved Cardiac Functional Imaging Using Temporal Regularization for Small Animal on a Clinical 3T Scanner

  2012cites this paper
• Characterization of the failing murine heart in a desmin knock-out model using a clinical 3 T MRI scanner

  2012cites this paper
• uantitative proton MRI and MRS of the rat brain ith a 3 T clinical MR scanner nalyse quantitative en IRM et spectroscopie RM du proton du cerveau du at sur une IRM clinique 3

  2011cites this paper
• Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats.

  2011influential citation
• Quantitative proton MRI and MRS of the rat brain with a 3T clinical MR scanner

  2011cites this paper
• Quantitative proton MRI and MRS of the rat brain with a 3 T clinical MR scanner Analyse quantitative en IRM et spectroscopie RM du proton du cerveau du rat sur une IRM clinique 3 T

  2011cites this paper
• Impact of tissue microstructure on a model of cardiac electromechanics based on MRI data

  2011influential citation
• Quantitative proton MRI and MRS of the rat brain with a 3T clinical MR scanner.

  2011cites this paper
• Cardiac troponin T and creatine kinase predict mid‐term infarct size and left ventricular function after acute myocardial infarction: A cardiac MR study

  2011cites this paper
• Review of Journal of Cardiovascular Magnetic Resonance 2009

  2010cites this paper
• In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium.

  2010cites this paper
• Current Awareness in NMR in Biomedicine

  2009cites this paper