Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  International Journal of Oncology

• Publication date

  2012-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijo.2012.1546PMID 22767021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria‐mediated apoptosis and DNA damage in p53 mutant leukemic T cells

  2012cited by this paper
• Generation of Reactive Oxygen Species during Apoptosis Induced by DNA-Damaging Agents and/or Histone Deacetylase Inhibitors

  2011cited by this paper
• Epigenetics in cancer: what's the future?

  2011cited by this paper
• Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells.

  2011cited by this paper
• Biliverdin reductase A in the prevention of cellular senescence against oxidative stress

  2011cited by this paper
• p53 Independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

  2011cited by this paper
• New nucleoside analogs for patients with hematological malignancies

  2011cited by this paper
• Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling.

  2010cited by this paper
• Methylation of DNA in cancer.

  2010cited by this paper
• Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

  2010cited by this paper
• 5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.

  2010cited by this paper
• Decitabine in the treatment of myelodysplastic syndromes

  2010cited by this paper
• 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway.

  2010cited by this paper
• The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing*

  2009cited by this paper
• Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation

  2009cited by this paper
• Targeting DNA Methylation

  2009cited by this paper
• 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.

  2009cited by this paper
• 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells.

  2009cited by this paper
• Sanguinarine, a Benzophenanthridine Alkaloid, Induces Apoptosis in MDA-MB-231 Human Breast Carcinoma Cells through a Reactive Oxygen Species-Mediated Mitochondrial Pathway

  2008cited by this paper
• Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells.

  2008cited by this paper
• The use of hypomethylating agents in the treatment of hematologic malignancies

  2007cited by this paper
• A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP

  2007cited by this paper
• Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells

  2006cited by this paper
• DNA mismatch repair as an effector for promoting phorbol ester‐induced apoptotic DNA damage and cell killing: Implications in tumor promotion

  2006cited by this paper
• Bioenergetic aspects of apoptosis, necrosis and mitoptosis

  2006cited by this paper
• Bcl‐2 changes conformation to inhibit Bax oligomerization

  2006cited by this paper
• Overview of cell death signaling pathways

  2005cited by this paper
• Reactive oxygen species and the modulation of stroke.

  2005cited by this paper
• DNA methylation and human disease

  2005cited by this paper
• The molecular basis of leukemia.

  2004cited by this paper
• Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities

  2003cited by this paper
• Reactivating the expression of methylation silenced genes in human cancer

  2002cited by this paper
• Mitochondrial reactive oxygen species in cell death signaling.

  2002cited by this paper
• Apoptosis: The little devil of death

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Leukocytosis: basics of clinical assessment.

  2000cited by this paper
• More than one way to die: apoptosis, necrosis and reactive oxygen damage

  1999cited by this paper
• Oxidant, mitochondria and calcium: an overview.

  1999cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

  1994cited by this paper
• Cellular differentiation, cytidine analogs and DNA methylation.

  1980cited by this paper

• Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line.

  2025cites this paper
• Exploration of the Therapeutic Potential of the Epigenetic Modulator Decitabine on 6-OHDA-Induced Experimental Models of Parkinson's Disease.

  2025cites this paper
• Role of reactive oxygen species in myelodysplastic syndromes

  2024cites this paper
• Applying cell painting in non-tumorigenic breast cells to understand impacts of common chemical exposures.

  2024cites this paper
• Applying Cell Painting in Non-Tumorigenic Breast Cells to Understand Impacts of Common Chemical Exposures

  2024cites this paper
• Effect of Zebularine on Apoptotic Pathways in Hepatocellular Carcinoma Cell Lines

  2023cites this paper
• Synergistic cytotoxicity of decitabine and YM155 in leukemia cells through upregulation of SLC35F2 and suppression of MCL1 and survivin expression

  2023cites this paper
• The Effect of 5-aza,2’-deoxyCytidine (5 AZA CdR or Decitabine) on Extrinsic, Intrinsic, and JAK/STAT Pathways in Neuroblastoma and Glioblastoma Cells Lines

  2023cites this paper
• Effect of 5’-Fluoro-2’-Deoxycytidine and Sodium Butyrate on the Gene Expression of the Intrinsic Apoptotic Pathway, p21, p27, and p53 Genes Expression, Cell Viability, and Apoptosis in Human Hepatocellular Carcinoma Cell Lines

  2023cites this paper
• DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma

  2022cites this paper
• Trailing TRAIL resistance in human breast adenocarcinoma cells with Trichostatin A and Zebularine.

  2022cites this paper
• Generalist in allogeneic hematopoietic stem cell transplantation for MDS or AML: Epigenetic therapy

  2022cites this paper
• Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models.

  2022cites this paper
• Effect of 5'-fluoro-2'-deoxycytidine and sodium butyrate on the genes of the intrinsic apoptotic pathway, p21, p53, cell viability, and apoptosis in human hepatocellular carcinoma cell lines

  2021cites this paper
• Synergistic inhibitory effects of low-dose decitabine in combination with bortezomib in the AML cell line Kasumi-1

  2021cites this paper
• Decitabine Enhances Acute Myeloid Leukemia Cell Apoptosis through SH3BGRL Upregulation.

  2021cites this paper
• EVI1 Promotes Metastasis by Downregulating TIMP2 in Metastatic Colon and Breast Cancer Cells.

  2021cites this paper
• Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

  2021cites this paper
• Erhöhung der Sensitivität des klassischen Hodgkin Lymphoms auf epigenetische Therapie

  2019cites this paper
• Synergistic effect of epigenetic inhibitors decitabine and suberoylanilide hydroxamic acid on colorectal cancer in vitro

  2019cites this paper
• Decitabine promotes apoptosis in mesenchymal stromal cells isolated from patients with myelodysplastic syndromes by inducing reactive oxygen species generation.

  2019cites this paper
• The synergistic antileukemic effects of eltrombopag and decitabine in myeloid leukemia cells

  2019influential citation
• The synergistic antileukemic effects of eltrombopag and decitabine in myeloid leukemia cells

  2019influential citation
• Changes in the physicochemical properties of fish cell membranes during cellular senescence

  2019cites this paper
• Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

  2019cites this paper
• Combining Oncolytic Viruses with Epigenetic Modifiers to Treat Acute Lymphocytic Leukemias

  2018cites this paper
• Epigenetic therapy: azacytidine and decitabine in acute myeloid leukemia

  2018cites this paper
• Resolving drug effects in patient-derived cancer cells links organoid responses to genome alterations

  2017cites this paper
• 5‑aza‑2'‑deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL2‑CCR2‑ERK signaling pathway.

  2017cites this paper
• Aza 5 ‐ aza ‐ 2 ' ‐ deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL 2 ‐ CCR 2 ‐ ERK signaling pathway

  2017cites this paper
• Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

  2017cites this paper
• Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways.

  2016cites this paper
• Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents

  2016cites this paper
• ROS and Epigenetics

  2016cites this paper
• Decitabine as a First-Line Treatment for Older Adults Newly Diagnosed with Acute Myeloid Leukemia

  2016cites this paper
• Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.

  2015cites this paper
• Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

  2015cites this paper
• Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS Generating Enzymes

  2014cites this paper
• Epigenetic Therapy of Cancer

  2014cites this paper
• Canonical and new generation anticancer drugs also target energy metabolism

  2014cites this paper
• Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update

  2014cites this paper
• Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and treatment: what can be learned from hematologic malignancies?

  2013cites this paper
• Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

  2013cites this paper
• Epigenetics: a new therapeutic approach in chronic lymphocytic leukemia

  2013cites this paper
• Screening drug effects in patient�derived cancer cells links organoid responses to genome alterations

  year unknowncites this paper