Ryanodine Receptor Adaptation

In the heart, depolarization during the action potential activates voltage-dependent Ca2+ channels that mediate a small, localized Ca2+ influx (ICa). This small Ca2+ signal activates specialized Ca2+ release channels, the ryanodine receptors (RyRs), in the sarcoplasmic reticulum (SR). This process

• Publication year

  2000

• Venue

  The Journal of General Physiology

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1085/JGP.116.6.873PMID 11099353PMCID 2231812
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Markovian models of low and high activity levels of cardiac ryanodine receptors.

  2001cited by this paper
• Questions about Adaptation in Ryanodine Receptors

  2000cited by this paper
• Phasic characteristic of elementary Ca2+ release sites underlies quantal responses to IP3

  2000cited by this paper
• Ca2+ sparks and Ca2+ waves in saponin‐permeabilized rat ventricular myocytes

  1999cited by this paper
• Rapid Activation of the Cardiac Ryanodine Receptor by Submillisecond Calcium Stimuli

  1999influential reference
• Modal gating transitions in cardiac ryanodine receptors during increases of Ca2+ concentration produced by photolysis of caged Ca2+

  1999influential reference
• Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage.

  1998influential reference
• Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.

  1998influential reference
• Kinetic model for ryanodine receptor adaptation

  1998influential reference
• Inactivation of Ca 2 1 Release Channels (Ryanodine Receptors RyR1 and RyR2) with Rapid Steps in [Ca 2 1 ] and Voltage

  1998cited by this paper
• Local Control Model of Excitation–Contraction Coupling in Skeletal Muscle

  1997cited by this paper
• ‘Quantal’ calcium release operated by membrane voltage in frog skeletal muscle

  1997cited by this paper
• Adaptation of single cardiac ryanodine receptor channels.

  1997cited by this paper
• Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis

  1997influential reference
• Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels.

  1996cited by this paper
• Response of ryanodine receptor channels to Ca2+ steps produced by rapid solution exchange.

  1996influential reference
• A minimal gating model for the cardiac calcium release channel.

  1996cited by this paper
• Ca2+ activation and Ca2+ inactivation of canine reconstituted cardiac sarcoplasmic reticulum Ca(2+)‐release channels.

  1995influential reference
• New insights into the gating mechanisms of cardiac ryanodine receptors revealed by rapid changes in ligand concentration.

  1995influential reference
• Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle

  1995cited by this paper
• Description of modal gating of the cardiac calcium release channel in planar lipid membranes.

  1995influential reference
• Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation.

  1995influential reference
• Activation of single cardiac and skeletal ryanodine receptor channels by flash photolysis of caged Ca2+.

  1994influential reference
• Negative control mechanism with features of adaptation controls Ca2+ release in cardiac myocytes.

  1994cited by this paper
• Ca(2+)-induced Ca2+ release in response to flash photolysis.

  1994influential reference
• Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart.

  1993influential reference
• Theory of excitation-contraction coupling in cardiac muscle.

  1992cited by this paper
• Ca2(+)-induced Ca2+ release as examined by photolysis of caged Ca2+ in single ventricular myocytes.

  1990cited by this paper
• Time and calcium dependence of activation and inactivation of calcium- induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell

  1985influential reference

• Local Control Model of a Human Ventricular Myocyte: An Exploration of Frequency-Dependent Changes and Calcium Sparks

  2023cites this paper
• Elementary intracellular Ca signals approximated as a transition of release channel system from a metastable state.

  2023cites this paper
• Modulation of K V 7 Channel Deactivation by PI(4,5)P 2

  2020cites this paper
• Mathematical models for intra- and inter-cellular Ca2+ wave propagations

  2020cites this paper
• Modulation of KV7 Channel Deactivation by PI(4,5)P2

  2020cites this paper
• 6 – Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

  2018cites this paper
• The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis

  2017cites this paper
• Hysteresis in voltage-gated channels

  2016cites this paper
• Nonequilibrium Enhances Adaptation Efficiency of Stochastic Biochemical Systems

  2016cites this paper
• Ca 2 + Signaling in Cytoskeletal Reorganization , Cell Migration , and Cancer Metastasis

  2015cites this paper
• The Nonlinear Dynamics of Calcium

  2015cites this paper
• A human ventricular myocyte model with a refined representation of excitation-contraction coupling.

  2015cites this paper
• Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction.

  2014cites this paper
• Statistical analysis of modal gating in ion channels

  2014cites this paper
• The human cardiac ryanodine receptor gating behaviour : a study of mechanisms

  2014cites this paper
• Overshoot in biological systems modelled by Markov chains: a non-equilibrium dynamic phenomenon.

  2013cites this paper
• Local control in cardiac E-C coupling.

  2012cites this paper
• Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP.

  2012cites this paper
• Protective Effect of FK506 on Myocardial Ischemia/Reperfusion Injury by Suppression of CaN and ASK1 Signaling Circuitry

  2011cites this paper
• Integrative Systems Models of Cardiac Excitation–Contraction Coupling

  2011cites this paper
• Luminal Ca(2+) content regulates intracellular Ca(2+) release in subepicardial myocytes of intact beating mouse hearts: effect of exogenous buffers.

  2010cites this paper
• Ryanodine receptor-mediated arrhythmias and sudden cardiac death

  2009cites this paper
• Inositol trisphosphate receptor and ion channel models based on single-channel data.

  2009cites this paper
• A Computational Analysis of Localized Ca2+-Dynamics Generated by Heterogeneous Release Sites

  2009cites this paper
• Intra‐sarcoplasmic reticulum Ca2+ oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+ in cardiomyocytes

  2009cites this paper
• Calcium sparks.

  2008cites this paper
• Calcium signaling phenomena in heart diseases: a perspective

  2007cites this paper
• Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels

  2007cites this paper
• Rapid ligand‐regulated gating kinetics of single inositol 1,4,5‐trisphosphate receptor Ca2+ release channels

  2007cites this paper
• Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria.

  2007cites this paper
• Rôle du NAADP et de son enzyme de synthèse, l'ADP ribosyl cyclase, dans les neurones : La régulation de l'homéostasie calcique nucléaire

  2007cites this paper
• Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.

  2007influential citation
• Adaptive control of intracellular Ca2+ release in C2C12 mouse myotubes

  2006cites this paper
• Simulation of Ca2+-activated Cl− current of cardiomyocytes in rabbit pulmonary vein: implications of subsarcolemmal Ca2+ dynamics

  2006cites this paper
• Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.

  2006cites this paper
• Abnormal ryanodine receptor function in heart failure.

  2005cites this paper
• Altered intracellular Ca2+ handling in heart failure.

  2005cites this paper
• Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons.

  2005cites this paper
• Calcium Activation of Ryanodine Receptor Channels—Reconciling RyR Gating Models with Tetrameric Channel Structure

  2005cites this paper
• Models of the inositol trisphosphate receptor.

  2005cites this paper
• Receptors, sparks and waves in a fire-diffuse-fire framework for calcium release.

  2004cites this paper
• Calcium Regulation of Single Ryanodine Receptor Channel Gating Analyzed Using HMM/MCMC Statistical Methods

  2004influential citation
• Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes.

  2004cites this paper
• Analysing cardiac excitation-contraction coupling with mathematical models of local control.

  2004cites this paper
• The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells.

  2004cites this paper
• Functional Significance of Ryanodine Receptor-Mediated Calcium Leaks in Sarcoplasmic Reticulum Membranes

  2004cites this paper
• Ca2+ sparks induced by Na/Ca exchange.

  2003cites this paper
• Simulation of waves in calcium models with 3D spherical geometry.

  2003cites this paper
• Dynamics of Cardiac Intracellular CA2+ Handling - from Experiments to Virtual Cells

  2003cites this paper
• Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles.

  2003cites this paper
• Luminal Ca2+ Controls Termination and Refractory Behavior of Ca2+-Induced Ca2+ Release in Cardiac Myocytes

  2002cites this paper
• The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis.

  2002cites this paper
• Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.

  2002cites this paper
• Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle.

  2002cites this paper
• Luminal Ca 2 (cid:1) Controls Termination and Refractory Behavior of Ca 2 (cid:1) -Induced Ca 2 (cid:1) Release in Cardiac Myocytes Cellular Biology

  2002cites this paper
• Ryanodine receptor calcium release channels.

  2002cites this paper
• Markovian models of low and high activity levels of cardiac ryanodine receptors.

  2001cites this paper
• Proceedings of the Australian Physiological and Pharmacological Society Symposium: New Frontiers in Muscle Research
The power of single channel recording and analysis: its application to ryanodine receptors in lipid bilayers

  2001cites this paper
• Questions about Adaptation in Ryanodine Receptors

  2000cites this paper
• Frequency- and hypertrophy-mediated alterations in twitch force and intracellular calcium transients in rat cardiac trabecula

  1998cites this paper
• Adaptive control of intracellular Ca2+ release in C2C12 mouse myotubes

  1996cites this paper