The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecules and Cells

• Publication date

  2012-11-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molcel.2012.08.026PMID 23022381PMCID PMC3496002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular chaperone-mediated nuclear protein dynamics.

  2014cited by this paper
• Expanding the cellular molecular chaperone network through the ubiquitous cochaperones.

  2012cited by this paper
• Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

  2011cited by this paper
• Global functional map of the p23 molecular chaperone reveals an extensive cellular network.

  2011cited by this paper
• Determinants and dynamics of genome accessibility

  2011cited by this paper
• HSP90 manages the ends.

  2010cited by this paper
• Chromatin Landscape Dictates HSF Binding to Target DNA Elements

  2010cited by this paper
• GCN5 Is a Positive Regulator of Origins of DNA Replication in Saccharomyces cerevisiae

  2010cited by this paper
• Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle

  2009cited by this paper
• Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

  2009cited by this paper
• THE HSP82 MOLECULAR CHAPERONE CAN PROMOTE A SWITCH BETWEEN UNEXTENDABLE AND EXTENDABLE TELOMERE STATES

  2009cited by this paper
• Transcription dynamics.

  2009cited by this paper
• Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

  2009influential reference
• HSP90: The Rosetta stone for cellular protein dynamics?

  2008cited by this paper
• Lysine acetylation: codified crosstalk with other posttranslational modifications.

  2008cited by this paper
• Is there a code embedded in proteins that is based on post-translational modifications?

  2008cited by this paper
• The Hsp90 Molecular Chaperone Modulates Multiple Telomerase Activities

  2007cited by this paper
• Loss of Gcn5 Acetyltransferase Activity Leads to Neural Tube Closure Defects and Exencephaly in Mouse Embryos

  2007cited by this paper
• Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation

  2007cited by this paper
• The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation

  2007cited by this paper
• Protein misassembly: macromolecular crowding and molecular chaperones.

  2007cited by this paper
• HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.

  2006cited by this paper
• The Hsp90 Cochaperone p23 Is Essential for Perinatal Survival

  2006cited by this paper
• How can biochemical reactions within cells differ from those in test tubes?

  2006cited by this paper
• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

  2004cited by this paper
• Global position and recruitment of HATs and HDACs in the yeast genome.

  2004cited by this paper
• Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

  2004cited by this paper
• Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.

  2004cited by this paper
• Estrogen Receptor-Directs Ordered , Cyclical , and Combinatorial Recruitment of Cofactors on a Natural Target

  2003cited by this paper
• Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation

  2003cited by this paper
• Nuclear receptor function requires a TFTC-type histone acetyl transferase complex.

  2002cited by this paper
• DNA replication in eukaryotic cells.

  2002cited by this paper
• Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones

  2002cited by this paper
• Characterization of the ECB Binding Complex Responsible for the M/G1-Specific Transcription of CLN3 and SWI4

  2002cited by this paper
• The concept of self-organization in cellular architecture

  2001cited by this paper
• Continuous recycling: a mechanism for modulatory signal transduction.

  2001influential reference
• Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone*

  2000cited by this paper
• The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies.

  2000cited by this paper
• The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.

  2000cited by this paper
• Orchestrated response: a symphony of transcription factors for gene control.

  2000cited by this paper
• Identification of target sites of the alpha2-Mcm1 repressor complex in the yeast genome.

  1999cited by this paper
• New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.

  1999cited by this paper
• Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

  1997cited by this paper
• Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

  1996cited by this paper
• The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive

  1995cited by this paper
• Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

  1991cited by this paper
• Quantitative analysis of the glucocorticoid receptor-DNA interaction at the mouse mammary tumor virus glucocorticoid response element.

  1990cited by this paper
• Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

  1988cited by this paper
• Proteins as molecular chaperones

  1987cited by this paper
• Steroid receptor regulated transcription of specific genes and gene networks.

  1985cited by this paper
• Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element.

  1984cited by this paper
• Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.

  1984cited by this paper
• Early Events in the Stimulation of Mammary Tumor Virus RNA Synthesis by Glucocorticoids

  1984cited by this paper
• Role of subunit interactions in the self-assembly of oligomeric proteins.

  1984cited by this paper

• HDAC1 is involved in the destabilization of the HSF2 protein under nonstress and stress conditions

  2025cites this paper
• Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator

  2025cites this paper
• Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

  2025cites this paper
• HSF1 Activation Mechanisms, Disease Roles, and Small Molecule Therapeutics

  2025cites this paper
• TRiC/CCT Chaperonin Governs RNA Polymerase II Activity in the Nucleus to Support RNA Homeostasis

  2024cites this paper
• The heat shock factor code: Specifying a diversity of transcriptional regulatory programs broadly promoting stress resilience

  2024cites this paper
• The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat‐shocked cells

  2023cites this paper
• p23 and Aha1: Distinct Functions Promote Client Maturation.

  2023cites this paper
• Regulation of HSF1 transcriptional complexes under proteotoxic stress

  2023cites this paper
• HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

  2022cites this paper
• HSF1 and Its Role in Huntington's Disease Pathology.

  2022cites this paper
• The heat shock response and small molecule regulators.

  2021cites this paper
• Molecular mechanisms of heat shock factor 1 regulation.

  2021cites this paper
• Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

  2020cites this paper
• Molecular Mechanisms of Heat Shock Factors in Cancer

  2020cites this paper
• Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation.

  2019cites this paper
• Functional principles and regulation of molecular chaperones.

  2019cites this paper
• The Hsp90 Molecular Chaperone Regulates the Transcription Factor Network Controlling Chromatin Accessibility.

  2019cites this paper
• CBP/EP300 acetylates and stabilizes the stress-responsive Heat Shock Factor 2, a process compromised in Rubinstein-Taybi syndrome

  2019cites this paper
• The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

  2019cites this paper
• Heat Shock Factor (HSF): The Promoter of Chaperone Genes. A Mini Review

  2018cites this paper
• CBP/EP300-dependent acetylation and stabilization of HSF2 are compromised in the rare disorder, Rubinstein-Taybi syndrome

  2018cites this paper
• Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23

  2017cites this paper
• The HSP90 chaperone machinery

  2017cites this paper
• Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling

  2017cites this paper
• Regulation of heat shock transcription factors and their roles in physiology and disease

  2017cites this paper
• Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions.

  2017cites this paper
• Versatile Functions of Heat Shock Factors: It is Not All About Stress

  2017influential citation
• Mechanistic Analysis of Conformational Dynamics of the Molecular Chaperone Hsp90

  2017cites this paper
• Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler.

  2016influential citation
• Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency

  2016cites this paper
• Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

  2016cites this paper
• Highly Multiplexed RNA Aptamer Selection using a Microplate-based Microcolumn Device

  2016cites this paper
• HSF1 Regulation in Aging and Its Role in Longevity

  2016cites this paper
• Structure of human heat-shock transcription factor 1 in complex with DNA

  2016cites this paper
• Information-sharing models for computational genetics

  2016cites this paper
• Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast.

  2015cites this paper
• HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes.

  2015cites this paper
• Chapter 3 Mechanisms of Glucocorticoid-Regulated Gene Transcription

  2015cites this paper
• Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1.

  2015cites this paper
• Mechanisms of Glucocorticoid-Regulated Gene Transcription.

  2015cites this paper
• Co-chaperone p23 Regulates C. elegans Lifespan in Response to Temperature

  2015cites this paper
• p23 and Aha1.

  2015cites this paper
• daf-41/p23: A Small Protein Heating Up Lifespan Regulation

  2015influential citation
• Emergence and Characterization of the p23 Molecular Chaperone

  2014influential citation
• The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

  2014influential citation
• Heat shock in the springtime

  2014cites this paper
• Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L

  2014cites this paper
• Proteomics of differential extraction fractions enriched for chromatin-binding proteins from colon adenoma and carcinoma tissues.

  2014cites this paper
• Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦

  2013cites this paper
• Hsp90@chromatin.nucleus: an emerging hub of a networker.

  2013cites this paper