A plethora of epidermal growth factor-like proteins in polycystic kidneys.

P. Wilson

Published 2004 in Kidney International

ABSTRACT

One of the first abnormalities described in cell biological studies of polycystic kidney disease pathogenesis was the abnormal apical plasma-membrane localization of the epidermal growth factor receptor (EGFR) in cyst lining epithelial cells, as opposed to the normal localization in mature kidneys on the basal membranes of proximal and nephron tubule segments1.

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