beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Carcinogenesis

• Publication date

  2001-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/22.2.315PMID 11181454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.

  2001cited by this paper
• Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression.

  2000cited by this paper
• Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate.

  2000cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• Curbing the nuclear activities of β‐catenin

  2000cited by this paper
• β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

  1999cited by this paper
• β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

  1999cited by this paper
• beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation.

  1999cited by this paper
• Cancer statistics, 1999

  1999cited by this paper
• Frequent mutations of the rat β‐catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1‐hydroxyanthraquinone

  1999cited by this paper
• Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.

  1999cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.

  1999cited by this paper
• Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier

  1999cited by this paper
• Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer

  1998cited by this paper
• High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

  1998cited by this paper
• Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake.

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

  1998cited by this paper
• Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?

  1998cited by this paper
• Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.

  1998cited by this paper
• Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

  1998cited by this paper
• Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.

  1998cited by this paper
• Expression of the immediate-early genes, c-fos, c-jun, and c-myc : A comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens

  1997cited by this paper
• Expression of the immediate-early genes, c-fos, c-jun, and c-myc: a comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens.

  1997cited by this paper
• Beta-catenin mutations in cell lines established from human colorectal cancers.

  1997cited by this paper
• β‐catenin is a target for the ubiquitin–proteasome pathway

  1997cited by this paper
• Chlorophylls as anticarcinogens (review).

  1997cited by this paper
• Assessment of mutations in ki‐ras and p53 in colon cancers from azoxymethane‐ and dimethylhydrazine‐treated rats

  1997cited by this paper
• Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.

  1997cited by this paper
• Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• beta-catenin is a target for the ubiquitin-proteasome pathway.

  1997cited by this paper
• Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.

  1997cited by this paper
• Genetic changes induced by heterocyclic amines.

  1997cited by this paper
• Overview of carcinogenic heterocyclic amines.

  1997cited by this paper
• Cancer-susceptibility genes. Gatekeepers and caretakers.

  1997cited by this paper
• Gatekeepers and caretakers

  1997cited by this paper
• Carcinogens and Anticarcinogens in the Human Diet

  1996cited by this paper
• Analysis of EGFR, TGF-alpha, neu and c-myc in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary tumors using RT-PCR.

  1995cited by this paper
• Progress in cancer chemoprevention: perspectives on agent selection and short-term clinical intervention trials.

  1994cited by this paper
• Dietary factors and risk of colon cancer.

  1994cited by this paper
• [Dietary factors and risk of colon cancer].

  1990cited by this paper
• Antimutagens and anticarcinogens: A survey of putative interceptor molecules

  1990cited by this paper
• Colon carcinogens: Their metabolism and mode of action

  1971cited by this paper

• Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

  2024cites this paper
• Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization

  2024cites this paper
• Molecular mechanisms associated with the chemoprotective role of protocatechuic acid and its potential benefits in the amelioration of doxorubicin-induced cardiotoxicity: A review

  2022cites this paper
• Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics

  2021cites this paper
• Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics

  2021cites this paper
• Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls

  2021cites this paper
• Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP)

  2020cites this paper
• Role of Phytochemicals in Modulating Signaling Cascades in Cancer Cells

  2020cites this paper
• Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals

  2020cites this paper
• BCL-3 and β-catenin signaling and tumor staging in colorectal cancer.

  2020cites this paper
• Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice

  2018cites this paper
• Morin and Esculetin supplementation modulates c‐myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2 ‐ dimethylhydrazine

  2017cites this paper
• Divergent roles of p120‐catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen‐induced rat skin tumors

  2017cites this paper
• Indole-3-Carbinol and Its Role in Chronic Diseases.

  2016cites this paper
• Nutri-epigenetics and synthetic analogs in cancer chemoprevention.

  2016cites this paper
• Novel Cancer Chemotherapy Hits by Molecular Topology: Dual Akt and Beta-Catenin Inhibitors

  2015cites this paper
• High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate.

  2014cites this paper
• Dietary Chlorella protects against heterocyclic amine-induced aberrant gene expression in the rat colon by increasing fecal excretion of unmetabolized PhIP.

  2013cites this paper
• 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways.

  2012cites this paper
• Anticancer activity of new (tetrazol-5-yl)methylindole derivatives and their acyclic c-nucleoside analogs.

  2012cites this paper
• Regulation of Nur77 expression by β‐catenin and its mitogenic effect in colon cancer cells

  2011cites this paper
• Anticlastogenic and anticarcinogenic potential of Thai bitter gourd fruits.

  2011cites this paper
• Chemoprevention molecular and biochemical mechanisms involved in cancer control and management

  2011cites this paper
• Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives, their 1,2,4-triazole thioglycosides and acyclic analogs

  2011cites this paper
• Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model.

  2010cites this paper
• Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects.

  2010cites this paper
• Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health.

  2009cites this paper
• Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.

  2008cites this paper
• Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

  2008cites this paper
• β‐catenin is strongly elevated in rat colonic epithelium following short‐term intermittent treatment with 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) and a high‐fat diet

  2008cites this paper
• A New Medium-term Rat Colorectal Bioassay Applying Neoplastic Lesions as End Points for Detection of Carcinogenesis Modifiers Effects with Weak or Controversial Modifiers

  2008cites this paper
• The Dietary Phytochemical Chlorophyllin Alters E-Cadherin and β -Catenin Expression in Human Colon Cancer Cells 1,2,3

  2008cites this paper
• Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.

  2007cites this paper
• Allelochemical Induction of Cytochrome P450 Monooxygenases and Amelioration of Xenobiotic Toxicity in Helicoverpa zea

  2007cites this paper
• Transcriptional regulation of livin by β-catenin/TCF signaling in human lung cancer cell lines

  2007cites this paper
• Comparison of White Tea, Green Tea, Epigallocatechin-3-Gallate, and Caffeine as Inhibitors of PhIP-Induced Colonic Aberrant Crypts

  2007cites this paper
• La clorofilina como modulador y protector de daño al ADN: experiencia en el ratón in vivo

  2007cites this paper
• Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving β-catenin, c-Myc and E2F1

  2007cites this paper
• IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

  2006cites this paper
• Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.

  2006cites this paper
• Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice.

  2006cites this paper
• Lysosomal trafficking of β-catenin induced by the tea polyphenol epigallocatechin-3-gallate

  2005cites this paper
• Chemopreventive Potential of Compounds in Cruciferous Vegetables

  2005cites this paper
• Mucin‐depleted foci have β‐catenin gene mutations, altered expression of its protein, and are dose‐ and time‐dependent in the colon of 1,2‐dimethylhydrazine‐treated rats

  2005cites this paper
• Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives

  2005cites this paper
• Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.

  2005cites this paper
• Expression in Human Colon Cancer Cells 1-3

  2004cites this paper
• The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.

  2004cites this paper
• Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.

  2004cites this paper
• Phosphorylation and ubiquitination of oncogenic mutants of β-catenin containing substitutions at Asp32

  2004influential citation
• Cancer Chemopreventive Effects of Dietary Phytochemicals

  2004cites this paper
• Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines.

  2004cites this paper
• Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.

  2004cites this paper
• Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.

  2003cites this paper
• Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2‐dimethylhydrazine or 2‐amino‐3‐methylimidazo[4,5‐f]quinoline: Mutational ‘hotspots’ and the relative expression of β‐catenin and c‐jun

  2003cites this paper
• The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.

  2003cites this paper
• β‐Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas

  2003cites this paper
• Cancer chemoprevention with dietary phytochemicals

  2003cites this paper
• Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.

  2003cites this paper
• The Wnt signaling pathway in solid childhood tumors.

  2003cites this paper
• Analysis of beta-catenin, Ki-ras, and microsatellite stability in azoxymethane-induced colon tumors of BDIX/Orl Ico rats.

  2003cites this paper
• Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.

  2002cites this paper
• Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.

  2002cites this paper
• Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.

  2002cites this paper
• Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

  2002cites this paper
• Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for beta-catenin in inflammation-induced rat colon carcinogenesis.

  2002cites this paper
• Comments on the history and importance of aromatic and heterocyclic amines in public health.

  2002cites this paper
• Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds.

  2002cites this paper
• Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2‐amino‐3‐methylimidazo[4,5‐f]quinoline and treated post‐initiation with chlorophyllin

  2001cites this paper
• Different mutation status of the β‐catenin gene in carcinogen‐induced colon, brain, and oral tumors in rats

  2001cites this paper
• Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.

  2001cites this paper
• Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol.

  2001cites this paper