The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Oncogene

• Publication date

  2014-08-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2013.388PMID 24056961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AXL induces epithelial to mesenchymal transition and regulates the function of breast cancer stem cells

  2013cited by this paper
• Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer

  2012cited by this paper
• Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis

  2012cited by this paper
• Cancer stem cells and EMT in carcinoma

  2012cited by this paper
• Axl Is a Prognostic Marker in Oral Squamous Cell Carcinoma

  2012cited by this paper
• Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members.

  2011cited by this paper
• Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma

  2011cited by this paper
• Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative.

  2011cited by this paper
• Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

  2011cited by this paper
• Wnt controls the transcriptional activity of Kaiso through CK1ε-dependent phosphorylation of p120-catenin

  2011cited by this paper
• Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

  2010cited by this paper
• Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.

  2010cited by this paper
• R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.

  2010cited by this paper
• Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance

  2010cited by this paper
• Adherens junctions: from molecules to morphogenesis

  2010cited by this paper
• An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

  2010cited by this paper
• Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.

  2009cited by this paper
• Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

  2009cited by this paper
• Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

  2009cited by this paper
• Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen

  2009cited by this paper
• Identification of selective inhibitors of cancer stem cells by high-throughput screening.

  2009cited by this paper
• Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

  2009cited by this paper
• Cadherins in development and cancer.

  2008cited by this paper
• Axl and Growth Arrest–Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

  2008cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• Wnt/beta-catenin signaling in cancer stemness and malignant behavior.

  2007cited by this paper
• The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery

  2007cited by this paper
• Wnt/β-catenin signaling in cancer stemness and malignant behavior

  2007cited by this paper
• The Wnt/beta-catenin signaling pathway as a target in drug discovery.

  2007cited by this paper
• Desmosomes: a role in cancer?

  2007cited by this paper
• A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

  2007cited by this paper
• Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.

  2006cited by this paper
• The epithelial–mesenchymal transition: new insights in signaling, development, and disease

  2006cited by this paper
• Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

  2006cited by this paper
• Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.

  2006cited by this paper
• Evaluating the role of human papillomaviruses in conjunctival neoplasia

  2006cited by this paper
• Claudins upregulation in human colorectal cancer

  2005cited by this paper
• Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.

  2005cited by this paper
• Molecular requirements for epithelial-mesenchymal transition during tumor progression.

  2005cited by this paper
• Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

  2005cited by this paper
• Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia

  2005cited by this paper
• α-catenin: at the junction of intercellular adhesion and actin dynamics

  2004cited by this paper
• The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation.

  2004cited by this paper
• Tight junction proteins.

  2003cited by this paper
• Sticky business: orchestrating cellular signals at adherens junctions.

  2003cited by this paper
• Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent up-regulation in human colorectal cancers

  2002cited by this paper
• The cadherin-catenin adhesion system in signaling and cancer.

  2002cited by this paper
• Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers.

  2001cited by this paper
• Stem cells, cancer, and cancer stem cells

  2001cited by this paper
• Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis

  2000cited by this paper
• Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)

  1999cited by this paper
• A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

  1999cited by this paper
• Roles of plakoglobin end domains in desmosome assembly.

  1997cited by this paper
• Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases*

  1996cited by this paper
• The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

  1995cited by this paper
• axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

  1991cited by this paper
• Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

  1988cited by this paper

• Growth arrest specific-6 and angiotoxin receptor-like signaling drive oral regenerative wound repair.

  2025cites this paper
• AXL signaling in cancer: from molecular insights to targeted therapies

  2025cites this paper
• Revolutionizing non‐melanoma skin cancer treatment: Receptor tyrosine kinase inhibitors take the stage

  2024cites this paper
• The Role of the Neurotrophin Network in Skin Squamous Cell Cancer and the Novel Use of the Zebrafish System

  2024cites this paper
• Gas6/AXL pathway: immunological landscape and therapeutic potential

  2023cites this paper
• TAM family kinases as therapeutic targets at the interface of cancer and immunity

  2023cites this paper
• Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation

  2023cites this paper
• Therapeutic targeting of the functionally elusive TAM receptor family

  2023cites this paper
• AXL receptor tyrosine kinase inhibition improves the anti-tumor effects of CD8+ T cells by inducing CD103+ dendritic cell-mediated T cell priming.

  2023cites this paper
• The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples

  2023cites this paper
• Targeting receptor tyrosine kinase signaling: Avenues in the management of cutaneous squamous cell carcinoma

  2023cites this paper
• Exosomal non-coding RNAs have a significant effect on tumor metastasis

  2022influential citation
• AXL kinase inhibitors- A prospective model for medicinal chemistry strategies in anticancer drug discovery.

  2022cites this paper
• Antibody–Drug Conjugates as an Emerging Therapy in Oncodermatology

  2022cites this paper
• Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease.

  2022cites this paper
• Investigating Cutaneous Squamous Cell Carcinoma in vitro and in vivo: Novel 3D Tools and Animal Models

  2022cites this paper
• A tEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review)

  2022cites this paper
• The Zebrafish model in dermatology: an update for clinicians

  2022influential citation
• Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer

  2021cites this paper
• Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement.

  2021cites this paper
• Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer

  2021cites this paper
• Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

  2021cites this paper
• TAM Receptor Inhibition–Implications for Cancer and the Immune System

  2021cites this paper
• Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression

  2020cites this paper
• ZenoFishDb v1.1: A Database for Xenotransplantation Studies in Zebrafish

  2020cites this paper
• Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma

  2019cites this paper
• Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases

  2019cites this paper
• A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

  2019cites this paper
• Transcatheter arterial embolization combined with hypoxia-replicative oncolytic adenovirus perfusion enhances the therapeutic effect of hepatic carcinoma

  2019cites this paper
• AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

  2019influential citation
• Molecular Signatures for Combined Targeted Treatments in Diffuse Malignant Peritoneal Mesothelioma

  2019cites this paper
• The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.

  2019cites this paper
• Role of the receptor tyrosine kinase Axl in hepatocellular carcinoma and its clinical relevance.

  2019cites this paper
• CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression

  2018cites this paper
• Does Axl have potential as a therapeutic target in pancreatic cancer?

  2018cites this paper
• Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

  2018cites this paper
• Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors

  2018cites this paper
• Downregulation of estrogen‐related receptor alpha inhibits human cutaneous squamous cell carcinoma cell proliferation and migration by regulating EMT via fibronectin and STAT3 signaling pathways

  2018cites this paper
• Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma

  2018cites this paper
• Engineering Axl specific CAR and SynNotch receptor for cancer therapy

  2018cites this paper
• The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance

  2017cites this paper
• Signaling pathways and mesenchymal transition in pediatric high-grade glioma

  2017cites this paper
• Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype.

  2017cites this paper
• n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma

  2017cites this paper
• Giving AXL the axe: targeting AXL in human malignancy

  2017influential citation
• Gas6‐Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor‐progressive advantages

  2017cites this paper
• Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer

  2017cites this paper
• EVOLVING THERAPIES ( R BUKOWSKI , SECTION EDITOR ) Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies

  2017cites this paper
• Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL

  2017cites this paper
• Expression and clinical significance of AXL and NEK2 genes in oral squamous cell carcinoma (OSCC)

  2017cites this paper
• Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL

  2017cites this paper
• Axl and Its Mediated Signaling Axis in Cancer

  2017cites this paper
• The Receptor Tyrosine Kinase AXL in Cancer Progression

  2016cites this paper
• CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties.

  2016cites this paper
• Zebrafish as a Model for Systems Medicine R&D: Rethinking the Metabolic Effects of Carrier Solvents and Culture Buffers Determined by 1H NMR Metabolomics

  2016cites this paper
• Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells.

  2016cites this paper
• Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis

  2016cites this paper
• Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression

  2016cites this paper
• WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

  2016cites this paper
• Identification of novel Focal Adhesion Kinase binding partners and their biological functions in cancer cells

  2015cites this paper
• Proteogenomic insights into the nature of chemoresistance in Chronic Myelogenous Leukemia

  2015cites this paper
• Axl RTK and microRNAs in urogenital cancers

  2015cites this paper
• Increased tumor cell expression of Axl is a marker of aggressive features in breast cancer among African women

  2015cites this paper
• AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.

  2015cites this paper
• Axl as a mediator of cellular growth and survival

  2014cites this paper