Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Infection and Immunity

• Publication date

  2004-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.72.8.4911-4917.2004PMID 15271960PMCID PMC470684
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Opportunistic Intracellular Bacteria and Immunity

  2013cited by this paper
• Brucella Infections and Immunity

  2002cited by this paper
• The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell

  2002cited by this paper
• Aromatic Compound-Dependent Brucella suis Is Attenuated in Both Cultured Cells and Mouse Models

  2001cited by this paper
• Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.

  2001cited by this paper
• The genome sequence of the facultative intracellular pathogen Brucella melitensis

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival.

  2000cited by this paper
• 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis.

  2000cited by this paper
• The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus.

  2000cited by this paper
• Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

  2000cited by this paper
• Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK).

  1999cited by this paper
• Protection of Mice against Brucellosis by Vaccination with Brucella melitensisWR201(16MΔpurEK)

  1999cited by this paper
• Persistence and Protective Efficacy of aMycobacterium tuberculosis Auxotroph Vaccine

  1999cited by this paper
• A two‐component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence

  1998cited by this paper
• Biosynthesis of the Branched-Chain Amino Acids

  1998cited by this paper
• Bacterial persistence and immunity in goats vaccinated with a purE deletion mutant or the parental 16M strain of Brucella melitensis

  1996cited by this paper
• Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages

  1996cited by this paper
• Deletion of purE attenuates Brucella melitensis infection in mice

  1996cited by this paper
• The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

  1996cited by this paper
• Deletion of purE attenuates Brucella melitensis 16M for growth in human monocyte-derived macrophages

  1995cited by this paper
• Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics

  1995cited by this paper
• pBBR1MCS: a broad-host-range cloning vector.

  1994cited by this paper
• Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant

  1994cited by this paper
• Fundamentals of Biostatistics.

  1992cited by this paper
• Mutagenesis of Brucella abortus: comparative efficiency of three transposon delivery systems.

  1991cited by this paper
• Molecular characterization of the iron transport system mediated by the pJM1 plasmid in Vibrio anguillarum 775.

  1991cited by this paper
• Intracellular replication is essential for the virulence of Salmonella typhimurium.

  1991cited by this paper
• Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria

  1990cited by this paper
• Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria

  1990cited by this paper
• Effect of a purA mutation on efficacy of Salmonella live-vaccine vectors

  1989cited by this paper
• Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice

  1988cited by this paper
• Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

  1986cited by this paper
• Fundamentals of biostatistics

  1982cited by this paper
• Principles and practice of infectious diseases. Vols 1 and 2.

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Transport Systems for Alanine, Serine, and Glycine in Escherichia coli K-12

  1973cited by this paper
• Regulation of the Biosynthesis of the Branched-Chain Amino Acids

  1969cited by this paper
• CHAPTER 35 – Biosynthesis of Purine Nucleotides*

  1960cited by this paper
• The Nutrition of Brucellae: Growth in Simple Chemically Defined Media

  1948cited by this paper

• A requirement for Acinetobacter baumannii purine biosynthesis during lung infection is exacerbated by host zinc deficiency

  2026cites this paper
• Unraveling Burkholderia cenocepacia H111 fitness determinants using two animal models

  2025cites this paper
• Disruption of purine de novo synthesis pathway impairs membrane homeostasis, intracellular survival, and virulence of Brucella melitensis

  2025cites this paper
• Listeria monocytogenes uses de novo purine synthesis to enhance fitness in Lyoner-type sausage

  2024cites this paper
• Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar Typhimurium via the de novo purine pathway

  2024cites this paper
• Genome-wide analysis of Brucella melitensis growth in spleen of infected mice allows rational selection of new vaccine candidates

  2024cites this paper
• Pathophysiologic Insights into the Transition from Asymptomatic Bacteriuria to Urinary Tract Infection

  2023cites this paper
• Genomic diversity of Streptococcus uberis isolated from clinical mastitis of cattle in selected areas of Bangladesh

  2022cites this paper
• Identification of genetic elements required for Listeria monocytogenes growth under limited nutrient conditions and virulence by a screening of transposon insertion library

  2022cites this paper
• Nucleotide biosynthesis: the base of bacterial pathogenesis.

  2022cites this paper
• Antibiogram Screening and Detection of Virulence-Associated Genes in Brucella Species Acquired from Cattle in South Africa’s Eastern Cape Province

  2022cites this paper
• Construction and Characterization of purD Gene Deleted Brucella abortus

  2022cites this paper
• Whole-genome sequencing reveals high genetic diversity of Streptococcus uberis isolated from cows with mastitis

  2021cites this paper
• Interspecies Metabolic Complementation in Cystic Fibrosis Pathogens via Purine Exchange

  2021cites this paper
• Immunometabolism in human brucellosis: An emerging field of investigation.

  2021cites this paper
• Nucleotide metabolism pathway: the achilles’ heel for bacterial pathogens

  2021cites this paper
• Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA+ Chaperone ClpC for Host Cell Adaptation

  2021cites this paper
• De Novo Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a purR Mutant

  2020cites this paper
• Effect of O antigen ligase gene mutation on oxidative stress resistance and pathogenicity of NMEC strain RS218.

  2019cites this paper
• Identification of Genetic Features for Attenuation of Two Salmonella Enteritidis Vaccine Strains and Differentiation of These From Wildtype Isolates Using Whole Genome Sequencing

  2019cites this paper
• Artificial Selection for Pathogenicity Mutations in Staphylococcus aureus Identifies Novel Factors Relevant to Chronic Infection

  2019cites this paper
• The advances in brucellosis vaccines.

  2019cites this paper
• Brucella central carbon metabolism: an update

  2018cites this paper
• Development of new generation of vaccines for Brucella abortus

  2018cites this paper
• Uropathogenic Escherichia coli preferentially utilize metabolites in urine for nucleotide biosynthesis through salvage pathways.

  2018cites this paper
• Development and trial of vaccines against Brucella

  2017cites this paper
• Metals and the Biology and Virulence of Brucella

  2017cites this paper
• Probing the Genome-Scale Metabolic Landscape of Bordetella pertussis, the Causative Agent of Whooping Cough

  2017cites this paper
• Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge.

  2016cites this paper
• Differential gene expression of Piscirickettsia salmonis strains in adaptive response to different culture systems: a strategy to identify possible intracellular survival mechanisms and pathogenicity

  2016cites this paper
• Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli

  2016cites this paper
• Space: A Final Frontier for Vacuolar Pathogens

  2016cites this paper
• Booster vaccination with safe, modified, live-attenuated mutants of Brucella abortus strain RB51 vaccine confers protective immunity against virulent strains of B. abortus and Brucella canis in BALB/c mice.

  2015cites this paper
• Immune responses and protection induced by Brucella suis S2 bacterial ghosts in mice.

  2015cites this paper
• Mutation of purD and purF genes further attenuates Brucella abortus strain RB51.

  2015cites this paper
• Molecular mechanism involved in the response to hydrogen peroxide stress in Acinetobacter oleivorans DR1

  2015cites this paper
• Nonmammalian Infection Hosts Strain H111 Virulence Factors Using Identification of Burkholderia cenocepacia

  2014cites this paper
• Characterization and Protective Property of Brucella abortus cydC and looP Mutants

  2014cites this paper
• Brucella virulence mechanisms and implications in novel vaccines and drugs.

  2013cites this paper
• Progress in Brucella vaccine development

  2013influential citation
• Genetic and proteomic analyses of a Xanthomonas campestris pv. campestris purC mutant deficient in purine biosynthesis and virulence.

  2013cites this paper
• Genome Sequences of Three Live Attenuated Vaccine Strains of Brucella Species and Implications for Pathogenesis and Differential Diagnosis

  2012cites this paper
• SodA is a major metabolic antioxidant in Brucella abortus 2308 that plays a significant, but limited, role in the virulence of this strain in the mouse model.

  2012cites this paper
• Altered Transcriptome of the B. melitensis Vaccine Candidate 16MΔvjbR, Implications for Development of Genetically Marked Live Vaccine

  2012cites this paper
• Identification of the bacteriocin subtilosin A and loss of purL results in its high-level production in Bacillus amyloliquefaciens.

  2012cites this paper
• Identification of Burkholderia cenocepacia Strain H111 Virulence Factors Using Nonmammalian Infection Hosts

  2012cites this paper
• Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice

  2012cites this paper
• The 16MΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection.

  2011cites this paper
• Protective Live Oral Brucellosis Vaccines Stimulate Th1 and Th17 Cell Responses

  2011cites this paper
• Treponema denticola PurE Is a bacterial AIR carboxylase.

  2011cites this paper
• DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate.

  2010cites this paper
• A Burkholderia pseudomallei ΔpurM Mutant Is Avirulent in Immunocompetent and Immunodeficient Animals: Candidate Strain for Exclusion from Select-Agent Lists

  2010cites this paper
• Genome Degradation in Brucella ovis Corresponds with Narrowing of Its Host Range and Tissue Tropism

  2009cites this paper
• Random transposon vectors pUTTns for the markerless integration of exogenous genes into gram-negative eubacteria chromosomes.

  2009cites this paper
• Identification of Genes Contributing to the Virulence of Francisella tularensis SCHU S4 in a Mouse Intradermal Infection Model

  2009cites this paper
• Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host

  2009cites this paper
• Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol

  2008cites this paper
• The structure and mechanism of SAICAR synthetase

  2008influential citation
• Remodeling of the Streptococcus agalactiae Transcriptome in Response to Growth Temperature

  2008cites this paper
• Analysis of Burkholderia pseudomallei virulence and efficacy of potential therapeutics, The

  2007cites this paper
• The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi

  2007cites this paper
• Deletion of znuA Virulence Factor Attenuates Brucella abortus and Confers Protection against Wild-Type Challenge

  2006cites this paper
• Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2

  2006cites this paper
• Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival

  2006cites this paper
• Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris.

  2005cites this paper
• Regulation of purine biosynthesis by a eukaryotic‐type kinase in Streptococcus agalactiae

  2005cites this paper
• Systematic Targeted Mutagenesis of Brucella melitensis 16M Reveals a Major Role for GntR Regulators in the Control ofVirulence

  2005cites this paper