Inhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuroscience

• Publication date

  2013-12-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuroscience.2013.09.033PMID 24070631PMCID PMC3831340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.

  2014influential reference
• The Paradox of Akt-mTOR Interactions

  2013cited by this paper
• Endogenous Interleukin-1β in Neuropathic Rats Enhances Glutamate Release from the Primary Afferents in the Spinal Dorsal Horn through Coupling with Presynaptic N-Methyl-d-aspartic Acid Receptors*♦

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• Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion

  2013cited by this paper
• Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain

  2013cited by this paper
• Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

  2013cited by this paper
• The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.

  2013cited by this paper
• Paclitaxel‐induced neuropathic pain is age dependent and devolves on glial response

  2013cited by this paper
• Glycogen Synthase Kinase-3&bgr; Contributes to Remifentanil-Induced Postoperative Hyperalgesia via Regulating N-Methyl-D-Aspartate Receptor Trafficking

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• Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia.

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• Inhibition of GSK3 by lithium, from single molecules to signaling networks

  2012cited by this paper
• GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia.

  2012cited by this paper
• Lithium attenuates peripheral neuropathy induced by paclitaxel in rats.

  2012influential reference
• Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.

  2012cited by this paper
• Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation*

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• Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn

  2012cited by this paper
• Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain

  2012influential reference
• Prevention of paclitaxel‐induced peripheral neuropathy by lithium pretreatment

  2012influential reference
• europathic pain and reactive gliosis are reversed by dialdehydic compound in europathic pain rat models aria

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  2012influential reference
• Lithium attenuates pain-related behavior in a rat model of neuropathic pain: possible involvement of opioid system.

  2012influential reference
• The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.

  2011cited by this paper
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• The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries.

  2011cited by this paper
• Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes.

  2010cited by this paper
• Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

  2010influential reference
• Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats.

  2010influential reference
• Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats.

  2010influential reference
• Pathological and protective roles of glia in chronic pain

  2009influential reference
• Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

  2009influential reference
• Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

  2009influential reference
• Glycogen synthase kinase‐3 negatively regulates anti‐inflammatory interleukin‐10 for lipopolysaccharide‐induced iNOS/NO biosynthesis and RANTES production in microglial cells

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• Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn.

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• Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells.

  2008cited by this paper
• Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS

  2008influential reference
• Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester.

  2008cited by this paper
• The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.

  2008cited by this paper
• Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis1

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• IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

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• Neuron-glia crosstalk gets serious: role in pain hypersensitivity.

  2008cited by this paper
• Amitriptyline preserves morphine’s antinociceptive effect by regulating the glutamate transporter GLAST and GLT‐1 trafficking and excitatory amino acids concentration in morphine‐tolerant rats

  2007cited by this paper
• Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats

  2007cited by this paper
• Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons.

  2007cited by this paper
• Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia.

  2006cited by this paper
• Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy.

  2006cited by this paper
• The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.

  2006cited by this paper
• Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation.

  2006influential reference
• Studies of peripheral sensory nerves in paclitaxel‐induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction

  2006cited by this paper
• Genetic impairment of interleukin‐1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice

  2006cited by this paper
• Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT‐1/EAAT2 subtype

  2006cited by this paper
• Effects of Glycogen Synthase Kinase 3β and Cyclin-Dependent Kinase 5 Inhibitors on Morphine-Induced Analgesia and Tolerance in Rats

  2006influential reference
• Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.

  2005influential reference
• Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord

  2005cited by this paper
• Taxol‐induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients

  2004cited by this paper
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  2003cited by this paper
• Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the Pathogenesis of Neuropathic Pain in Rats

  2003influential reference
• Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

  2002cited by this paper
• Glutamate uptake.

  2001cited by this paper
• Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy

  2000influential reference
• Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy.

  1999cited by this paper
• Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons.

  1999cited by this paper
• Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.

  1997influential reference
• Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

  1993influential reference
• Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

  1990influential reference
• In vivo distribution of lithium in plasma and brain.

  1989cited by this paper
• A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

  1987cited by this paper
• Plasma and Brain Lithium Levels After Lithium Carbonate and Lithium Chloride Administration by Different Routes in Rats

  1971cited by this paper

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• Emerging Molecular and Synaptic Targets for the Management of Chronic Pain Caused by Systemic Lupus Erythematosus

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• Calcium signaling in chemotherapy-induced neuropathy.

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• Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies

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• Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy

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• Neuro-immune interactions in paclitaxel-induced peripheral neuropathy

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• Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin‐6 and cyclooxygenase‐2 and mechanical hypersensitivity in mice

  2018cites this paper
• Lithium as a disease-modifying agent for prion diseases

  2018cites this paper
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  2018cites this paper
• A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice

  2017cites this paper
• Ibudilast reduces oxaliplatin‐induced tactile allodynia and cognitive impairments in rats

  2017cites this paper
• Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy.

  2017cites this paper
• Chronic pain and impaired glial glutamate transporter function in lupus‐prone mice are ameliorated by blocking macrophage colony‐stimulating factor‐1 receptors

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• Nutritional Modulators in Chemotherapy-Induced Neuropathic Pain

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  2014cites this paper
• Effects of lithium on inflammation.

  2014cites this paper
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  2014influential citation
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  2014cites this paper
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