Lysophosphatidic Acid Promotes Survival and Differentiation of Rat Schwann Cells*

Lysophosphatidic acid (LPA; 1-acyl-sn-glycerol-3-phosphate), an abundant constituent of serum, mediates multiple biological responses via G protein-coupled serpentine receptors. Schwann cells express the LPA receptors (Edg receptors), which, once activated, have the potential to signal through Gαi to activate p21 ras and phosphatidylinositol 3-kinase, through Gαq to activate phospholipase C, or through Gq12/13 to activate the Rho pathway. We found that the addition of serum or LPA to serum-starved Schwann cells rapidly (10 min) induced the appearance of actin stress fibers via a Rho-mediated pathway. Furthermore, LPA was able to rescue Schwann cells from apoptosis in a Gαi/phosphatidylinositol 3-kinase/MEK/MAPK-dependent manner. In addition, LPA increased the expression of myelin protein P0 in Schwann cells in a Gαi-independent manner but dependent on protein kinase C. By means of pharmacological and overexpression approaches, we found that the novel isozyme protein kinase Cδ was required for myelin P0 expression. Thus, the multiple effects of LPA in Schwann cells (actin reorganization, survival, and myelin gene expression) appear to be mediated through the different G protein-dependent pathways activated by the LPA receptor.

• Publication year

  2003

• Venue

  Journal of Biological Chemistry

• Publication date

  2003-03-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.M213244200PMID 12524451
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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