Potential Role of TGF-β in Diabetic Nephropathy

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Mineral and Electrolyte Metabolism

• Publication date

  1998-02-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000057369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The Diabetes Control and Complications Trial

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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Elevated D-glucose concentrations modulate TGF-beta 1 synthesis by human cultured renal proximal tubular cells. The permissive role of platelet-derived growth factor.

  1995cited by this paper
• Role for transforming growth factor beta in thromboxane-induced increases in mesangial cell fibronectin synthesis.

  1995cited by this paper
• Decreased Degradative Enzymes in Mesangial Cells Cultured in High Glucose Media

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• Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Transforming growth factor beta in tissue fibrosis.

  1994cited by this paper
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  1994cited by this paper
• Transforming Growth Factor β in Tissue Fibrosis

  1994cited by this paper
• Expression of transforming growth factor-β1 during diabetic renal hypertrophy

  1994cited by this paper
• The emerging role of transforming growth factor-beta in kidney diseases.

  1994cited by this paper
• Activation of Protein Kinase C in Glomerular Cells in Diabetes: Mechanisms and Potential Links to the Pathogenesis of Diabetic Glomerulopathy

  1994cited by this paper
• Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse.

  1994cited by this paper
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  1994cited by this paper
• The extracellular matrix in diabetic nephropathy.

  1993cited by this paper
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  1993cited by this paper
• Rat mesangial cell hypertrophy in response to transforming growth factor-β1

  1993cited by this paper
• The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.

  1993cited by this paper
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  1993cited by this paper
• mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

  1993cited by this paper
• Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells

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• The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

  1993cited by this paper
• Renal tubular basement membrane and collagen type IV in diabetes mellitus.

  1993cited by this paper
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  1992cited by this paper
• Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

  1992cited by this paper
• Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule.

  1992cited by this paper
• Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.

  1992cited by this paper
• Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells.

  1992cited by this paper
• TGF-β: Regulation of extracellular matrix

  1992cited by this paper
• High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

  1992cited by this paper
• Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose.

  1991cited by this paper
• High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures.

  1991cited by this paper
• Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy

  1991cited by this paper
• Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium.

  1991cited by this paper
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  1991cited by this paper
• Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis.

  1991cited by this paper
• High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells.

  1990cited by this paper
• High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule.

  1990cited by this paper
• Characterization of the promoter region of the human transforming growth factor-beta 1 gene.

  1989cited by this paper
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  1989cited by this paper
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  1986cited by this paper
• Glomerular hemodynamics in experimental diabetes mellitus.

  1981cited by this paper

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  2013cites this paper
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  2011cites this paper
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  2010cites this paper
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  2009cites this paper
• Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study.

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  2009cites this paper
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• Activation of transforming growth factor-β1 in diabetic kidney disease

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• Consequences of the diabetic status on the oxidant/antioxidant balance.

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• IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin

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• Matrix metalloproteinases in renal development and disease.

  2000cites this paper
• F(2)-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes.

  2000cites this paper
• Aldose reductase inhibitors: therapeutic implications for diabetic complications.

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• Molecular Basis of Injury and Progression in Focal Glomerulosclerosis

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