Plasma protein S contains zinc essential for efficient activated protein C‐independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor

No abstract is available for this paper.

• Publication year

  2009

• Venue

  The FASEB Journal

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fj.08-123174PMID 19244162PMCID PMC2704590
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

  2012cited by this paper
• The Thrombin-sensitive Region of Protein S Mediates Phospholipid-dependent Interaction with Factor Xa*

  2008cited by this paper
• Hereditary Deficiency of Protein C or Protein S Confers Increased Risk of Arterial Thromboembolic Events at a Young Age: Results From a Large Family Cohort Study

  2008cited by this paper
• Predicting zinc binding at the proteome level

  2007cited by this paper
• Plasma contains protein S monomers and multimers with similar direct anticoagulant activity

  2006cited by this paper
• High Resolution Structures of p-Aminobenzamidine- and Benzamidine-VIIa/Soluble Tissue Factor

  2006cited by this paper
• Protein S multimers and monomers each have direct anticoagulant activity

  2006cited by this paper
• Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.

  2006cited by this paper
• Zinc coordination environments in proteins determine zinc functions.

  2005cited by this paper
• Merit Award Winners

  2004cited by this paper
• Direct anticoagulant activity of protein S‐C4b binding protein complex in Heerlen heterozygotes and normals *

  2004cited by this paper
• Crystal Structure of Mg2+- and Ca2+-bound Gla Domain of Factor IX Complexed with Binding Protein*

  2003cited by this paper
• The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation.

  2003cited by this paper
• Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements.

  2002cited by this paper
• Three high-resolution crystal structures of cadmium-substituted carboxypeptidase A provide insight into the enzymatic function

  2002cited by this paper
• Crystal Structure of Human Sex Hormone-binding Globulin in Complex with 2-Methoxyestradiol Reveals the Molecular Basis for High Affinity Interactions with C-2 Derivatives of Estradiol*

  2002cited by this paper
• Role of zinc ions in activation and inactivation of thrombin-activatable fibrinolysis inhibitor.

  2002cited by this paper
• Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6

  2002cited by this paper
• Three‐dimensional model of the SHBG‐like region of anticoagulant protein S: New structure–function insights

  2001cited by this paper
• Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity.

  2001cited by this paper
• Crystal structure of human sex hormone‐binding globulin: steroid transport by a laminin G‐like domain

  2000cited by this paper
• Calcium-binding EGF-like modules in coagulation proteinases: function of the calcium ion in module interactions.

  2000cited by this paper
• Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor

  2000cited by this paper
• C-terminal Residues 621–635 of Protein S Are Essential for Binding to Factor Va*

  1999cited by this paper
• Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain.

  1998cited by this paper
• A Plasma Coagulation Assay for an Activated Protein C-independent Anticoagulant Activity of Protein S

  1998cited by this paper
• Characterization of recombinant epidermal growth factor (EGF)-like modules from vitamin-K-dependent protein S expressed in Spodoptera cells--the cofactor activity depends on the N-terminal EGF module in human protein S.

  1998cited by this paper
• Magnesium(II) Is a Crucial Constituent of the Blood Coagulation Cascade

  1996cited by this paper
• Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa.

  1994cited by this paper
• Protein S binds to and inhibits factor Xa.

  1994cited by this paper
• Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.

  1993cited by this paper
• Gamma-carboxylated isoforms of recombinant human protein S with different biologic properties.

  1990influential reference
• Novel type of very high affinity calcium-binding sites in beta-hydroxyasparagine-containing epidermal growth factor-like domains in vitamin K-dependent protein S.

  1990cited by this paper
• Neonatal purpura fulminans associated with homozygous protein S deficiency.

  1990cited by this paper
• Gamma-carboxylated isoforms of recombinant human protein S with different biologic properties

  1990cited by this paper
• Plasma protein S deficiency in familial thrombotic disease.

  1984cited by this paper
• A procedure for isolation of human protein C and protein S as by-products of the purification of factors VII, IX, X and prothrombin.

  1983influential reference
• Regulation of activated protein C by a new protein. A possible function for bovine protein S.

  1980cited by this paper
• A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.

  1976influential reference
• The Role of Zinc in Carboxypeptidase

  1960cited by this paper

• Structural Insights into Zn2+ and Ca2+ binding to Human Protein Z and Their Impact on Membrane Association

  2025cites this paper
• Relationship between serum zinc level and sepsis-induced coagulopathy

  2021cites this paper
• Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis

  2018cites this paper
• Vitamin K–Dependent Protein S: Beyond the Protein C Pathway

  2017cites this paper
• Effect of solvent/detergent‐treated pooled plasma on fibrinolysis in reconstituted whole blood

  2017cites this paper
• Enhanced thrombin generation and reduced intact protein S in processed solvent detergent plasma.

  2015cites this paper
• Protein S Deficiency

  2015cites this paper
• Protein S Is a Cofactor for Platelet and Endothelial Tissue Factor Pathway Inhibitor-&agr; but Not for Cell Surface–Associated Tissue Factor Pathway Inhibitor

  2014influential citation
• Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

  2014cites this paper
• Zinc: An important cofactor in haemostasis and thrombosis

  2013cites this paper
• Plasma protein S residues 37–50 mediate its binding to factor Va and inhibition of blood coagulation

  2013cites this paper
• Zn2+ Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen*

  2013cites this paper
• Phosphorylation of protein S by platelet kinases enhances its activated protein C cofactor activity

  2013cites this paper
• Chapter 644 – Protein C

  2013cites this paper
• Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

  2012cites this paper
• Protein S : new insights into its functions

  2012cites this paper
• Platelet protein S directly inhibits procoagulant activity on platelets and microparticles

  2012cites this paper
• Protein S: an anticoagulant in its own right.

  2012cites this paper
• By increasing the affinity of heparin for fibrin, Zn(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin.

  2012cites this paper
• Protein S: an anticoagulant in its own right.

  2012cites this paper
• Platelet-mediated proteolytic down regulation of the anticoagulant activity of protein S in individuals with haematological malignancies

  2012cites this paper
• Tissue factor pathway inhibitor: structure-function.

  2012cites this paper
• Current understanding of thrombosis and hemostasis — from bench to bedside Protein C anticoagulant and cytoprotective pathways

  2012cites this paper
• Protein S: An anticoagulant in its own right

  2012cites this paper
• C4b-Binding Protein: A Forgotten Factor in Thrombosis and Hemostasis

  2011cites this paper
• Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.

  2011cites this paper
• Regulation of inflammation by the protein C system

  2010influential citation
• Bisaryl hydrazones as exchangeable biocompatible linkers.

  2010cites this paper
• Zn2+‐containing protein S inhibits extrinsic factor X‐activating complex independently of tissue factor pathway inhibitor

  2010cites this paper
• Protein S : Recent topics and deficient mice

  2010cites this paper
• Zinc Modulates the Interaction of Protein C and Activated Protein C with Endothelial Cell Protein C Receptor*

  2010cites this paper
• Zinc ions bind to and inhibit activated protein C

  2010influential citation
• Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma

  2010cites this paper
• Species-specific anticoagulant and mitogenic activities of murine protein S

  2009cites this paper
• Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.

  2009cites this paper