Altered fractionation radiotherapy in head and neck squamous cell carcinoma.

INTRODUCTION Fractionation plays a pivotal role in determining the effectiveness of radiation and follows the principle of 4 "R" of radiobiology. The various altered fractionation schedules used are hyper-fractionation, accelerated fractionation, and hypo fractionation. METHODS We reviewed the landmark articles published in the peer reviewed journals to summarize the beneficial role of altered fractionation in the treatment of head and neck carcinoma. RESULTS Hyper-fractionation definitely gives very good overall survival benefit for locally advanced head and neck patient's equivalent to survival benefit to that of concurrent chemoradiotherapy. Adding concomitant chemotherapy to altered fractionation is a logical approach to improve survival in locally advanced head and neck cancer patients, but it may be at a cost of higher toxicity. Mild hypo fractionation may be beneficial in early laryngeal cancers and may help in achieving better local control. CONCLUSION Altered fractionation is a very important treatment schema and requires the reinforcement of its use.

• Publication year

  2016

• Venue

  Journal of the Egyptian National Cancer Institute

• Publication date

  2016-06-01

• Fields of study

  Medicine, Physics

• Identifiers
  DOI 10.1016/j.jnci.2016.02.004PMID 26994645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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