Effects of obesity on sGCβ1 mediated signaling in white adipose tissue

Background Obesity has reached pandemic proportions with 1.9 billion overweight adults; 600 million of whom are obese [1]. It has been shown that stimulating cyclic 3’-5’ guanosine monophosphate (cGMP) signaling is able to promote adipose tissue homeostasis in obese mice [2]. Conversely, genetic depletion of cGMP dependent protein kinase 1 (PKG1), causes hepatic inflammation and fasting hyperglycemia in mice [3]. Furthermore, cGMP signaling is essential for differentiation of preadipocytes to mature adipocytes in vitro [4,5]. PKG1 activation blocks RhoA mediated inhibition of insulin receptor substrate 1 in adipocytes in vitro [4,5], thus maintaining insulin sensitivity. The status of cGMP signaling cascade in adipose tissue under obese conditions is not yet fully understood. Here, we examine the functional status of cGMP signaling in white adipose tissue (WAT) of lean and obese mice.

• Publication year

  2015

• Venue

  BMC Pharmacology and Toxicology

• Publication date

  2015-09-02

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1186/2050-6511-16-S1-A83PMCID 4565486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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