Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-12-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1415213112PMID 25535389PMCID PMC4291677
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.

  2014cited by this paper
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  2013cited by this paper
• Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation

  2012cited by this paper
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  2012cited by this paper
• TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

  2012cited by this paper
• Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

  2011cited by this paper
• Numb regulates Notch1, but not Notch3, during myogenesis.

  2011cited by this paper
• IKKβ Activation Is Sufficient for RANK-Independent Osteoclast Differentiation and Osteolysis

  2010cited by this paper
• Functions of nuclear factor κB in bone

  2010cited by this paper
• The multiple functions of Numb.

  2010cited by this paper
• NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.

  2010influential reference
• The TAK1-TRAF6 signalling pathway.

  2010cited by this paper
• Numb Regulates Post-endocytic Trafficking and Degradation of Notch1*

  2009cited by this paper
• Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis

  2009cited by this paper
• Role of the NF-κB axis in immune modulation of osteoclasts and bone loss

  2008cited by this paper
• TRAF6 Autoubiquitination-Independent Activation of the NFκB and MAPK Pathways in Response to IL-1 and RANKL

  2008cited by this paper
• NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.

  2008influential reference
• Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation*

  2008cited by this paper
• The Association of Notch2 and NF-κB Accelerates RANKL-Induced Osteoclastogenesis

  2008cited by this paper
• Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon

  2007cited by this paper
• Integrating cell-signalling pathways with NF-kappaB and IKK function.

  2007cited by this paper
• TRAFs in RANK signaling.

  2007cited by this paper
• Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL

  2006cited by this paper
• Lys63-linked polyubiquitin chains: Linking more than just ubiquitin

  2006cited by this paper
• A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

  2006cited by this paper
• Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

  2006cited by this paper
• Inhibition of IKK activation, through sequestering NEMO, blocks PMMA‐induced osteoclastogenesis and calvarial inflammatory osteolysis

  2006cited by this paper
• Role of nuclear factor‐κB in the immune system and bone

  2005cited by this paper
• Role of nuclear factor-kappaB in the immune system and bone.

  2005cited by this paper
• Ubiquitin signalling in the NF-κB pathway

  2005cited by this paper
• IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

  2005cited by this paper
• Advances in osteoclast differentiation and function.

  2005cited by this paper
• Ubiquitin signalling in the NF-kappaB pathway.

  2005influential reference
• TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

  2004cited by this paper
• The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.

  2004cited by this paper
• Signaling to NF-kappaB.

  2004cited by this paper
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  2004cited by this paper
• Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.

  2004cited by this paper
• Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of κB Kinase α*

  2004cited by this paper
• Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain*

  2003cited by this paper
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  2003cited by this paper
• TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

  2003cited by this paper
• LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin‐dependent degradation

  2002cited by this paper
• TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.

  2002cited by this paper
• Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.

  2002cited by this paper
• TAK1 is a ubiquitin-dependent kinase of MKK and IKK

  2001cited by this paper
• Notch signaling: from the outside in.

  2000cited by this paper
• TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

  1999cited by this paper
• Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

  1999cited by this paper
• Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

  1992cited by this paper

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  2025cites this paper
• Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases

  2025cites this paper
• Intake of eggshell membrane enhances bone mass and suppresses bone marrow adiposity in normal growing rats

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• CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity

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• Dual regulation of phaseol on osteoclast formation and osteoblast differentiation by targeting TAK1 kinase for osteoporosis treatment

  2024cites this paper
• DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation

  2023cites this paper
• Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases.

  2023cites this paper
• The Role of TAK1 in RANKL-Induced Osteoclastogenesis

  2022influential citation
• ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle

  2022cites this paper
• Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1

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• Methods to Analyze the Roles of TAK1, TRAF6, and NEMO in the Regulation of NF-κB Signaling by RANK Stimulation During Osteoclastogenesis.

  2021cites this paper
• CHI3L1 promotes Staphylococcus aureus-induced osteomyelitis by activating p38/MAPK and Smad signaling pathways.

  2021cites this paper
• Notch and its ligands

  2020cites this paper
• Basic Aspects of Osteoclast Differentiation and Function

  2020cites this paper
• Intrinsic Restriction of TNF-Mediated Inflammatory Osteoclastogenesis and Bone Resorption

  2020cites this paper
• Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor

  2020cites this paper
• Notch and the regulation of osteoclast differentiation and function.

  2020cites this paper
• Role of NFκB in Bone Remodeling in Health and Cancer

  2019cites this paper
• Regulatory network mediated by RBP‐J/NFATc1‐miR182 controls inflammatory bone resorption

  2019cites this paper
• Effect of TAK1 on osteogenic differentiation of mesenchymal stem cells by regulating BMP-2 via Wnt/β-catenin and MAPK pathway

  2018cites this paper
• TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

  2018cites this paper
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  2017cites this paper
• Notch and Myeloid Cells

  2017cites this paper
• NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

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  2016cites this paper
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