RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence

Cell cycle and DNA repair involve steps requiring RanGTP-regulated nuclear-cytoplasmic transport (NCT). The activation of NCT via overexpression of RCC1 (the guanine nucleotide exchange factor for Ran) accelerated the cell cycle and DNA repair. Normal cells overexpressing RCC1 evaded DNA damage–induced senescence, mimicking cancer cells with high levels of RCC1.

• Publication year

  2016

• Venue

  Molecular Biology of the Cell

• Publication date

  2016-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E16-01-0025PMID 26864624PMCID 4831887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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