Neurotoxicity of cancer chemotherapy☆

There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.

• Publication year

  2013

• Venue

  Neural Regeneration Research

• Publication date

  2013-06-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.3969/j.issn.1673-5374.2013.17.009PMID 25206457PMCID 4145960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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