Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Current Topics in Medicinal Chemistry

• Publication date

  2003-02-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/1568026033452276PMID 12678842
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance.

  2002cited by this paper
• Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains.

  2002cited by this paper
• Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages.

  2002cited by this paper
• PTP1B regulates leptin signal transduction in vivo.

  2002cited by this paper
• A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.

  2002cited by this paper
• Insulin signaling pathways in time and space.

  2002cited by this paper
• PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

  2002cited by this paper
• Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

  2002cited by this paper
• Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

  2002cited by this paper
• A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.

  2002cited by this paper
• Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development.

  2002cited by this paper
• Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts

  2002cited by this paper
• Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum

  2002cited by this paper
• Attenuation of Adhesion-dependent Signaling and Cell Spreading in Transformed Fibroblasts Lacking Protein Tyrosine Phosphatase-1B

  2001cited by this paper
• Insulin signalling and the regulation of glucose and lipid metabolism

  2001cited by this paper
• Knockout mice: a paradigm shift in modern immunology

  2001cited by this paper
• A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen-related protein tyrosine phosphatase activity.

  2001cited by this paper
• Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B.

  2001cited by this paper
• Insulin signalling.

  2001cited by this paper
• Protein-tyrosine Phosphatase-1B Negatively Regulates Insulin Signaling in L6 Myocytes and Fao Hepatoma Cells*

  2001cited by this paper
• Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade*

  2001cited by this paper
• The Reciprocal Role of Egr-1 and Sp Family Proteins in Regulation of the PTP1B Promoter in Response to the p210 Bcr-Abl Oncoprotein-tyrosine Kinase*

  2001cited by this paper
• Protein tyrosine phosphatases: prospects for therapeutics.

  2001cited by this paper
• Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats.

  2000cited by this paper
• Progress in antisense technology: the end of the beginning.

  2000cited by this paper
• Identification of Tyrosine Phosphatases That Dephosphorylate the Insulin Receptor

  2000cited by this paper
• Overexpression of Protein-tyrosine Phosphatase-1B in Adipocytes Inhibits Insulin-stimulated Phosphoinositide 3-Kinase Activity without Altering Glucose Transport or Akt/Protein Kinase B Activation*

  2000cited by this paper
• Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region*

  2000cited by this paper
• Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.

  2000cited by this paper
• The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development

  2000cited by this paper
• Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.

  2000cited by this paper
• Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

  2000cited by this paper
• No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase β

  2000cited by this paper
• Obesity and insulin resistance.

  2000cited by this paper
• A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b*

  2000cited by this paper
• PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.

  1999cited by this paper
• Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ

  1999cited by this paper
• Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase σ

  1999cited by this paper
• Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts.

  1999cited by this paper
• Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus.

  1999cited by this paper
• Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

  1999cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction

  1998cited by this paper
• Protein tyrosine phosphatase 1B negatively regulates integrin signaling.

  1998cited by this paper
• Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

  1998cited by this paper
• Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand

  1998cited by this paper
• Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B

  1998cited by this paper
• Insulin receptor internalization and signalling

  1998cited by this paper
• On raising energy expenditure in ob/ob mice.

  1997cited by this paper
• Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.

  1997cited by this paper
• Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.

  1997cited by this paper
• Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

  1997cited by this paper
• Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity.

  1997cited by this paper
• Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin*

  1997cited by this paper
• Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue.

  1997cited by this paper
• Insulin action impaired by deficiency of the G-protein subunit G ialpha2.

  1996cited by this paper
• Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.

  1996cited by this paper
• Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas*

  1996cited by this paper
• Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor

  1996cited by this paper
• The Transmembrane Protein-tyrosine Phosphatase LAR Modulates Signaling by Multiple Receptor Tyrosine Kinases (*)

  1996cited by this paper
• CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

  1996cited by this paper
• The Transmembrane Protein-tyrosine Phosphatase CD45 Is Associated with Decreased Insulin Receptor Signaling (*)

  1996cited by this paper
• Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities (*)

  1995cited by this paper
• Insulin Receptor Signaling Is Augmented by Antisense Inhibition of the Protein Tyrosine Phosphatase LAR (*)

  1995cited by this paper
• Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ε (*)

  1995cited by this paper
• Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway (*)

  1995cited by this paper
• Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets.

  1995cited by this paper
• Differential activities of protein tyrosine phosphatases in intact cells.

  1993cited by this paper
• The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.

  1992cited by this paper
• Expression of a protein tyrosine phosphatase in normal and v-src- transformed mouse 3T3 fibroblasts

  1992cited by this paper
• Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes

  1990cited by this paper
• Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

  1990cited by this paper
• Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

  1990cited by this paper
• Purification of the major protein-tyrosine-phosphatases of human placenta.

  1988cited by this paper
• Characterization of the major protein-tyrosine-phosphatases of human placenta.

  1988cited by this paper

• Inhibition of protein tyrosine phosphatase 1B by serratane triterpenes from Huperzia serrata and their molecular docking study.

  2024cites this paper
• In Vitro and In Silico Analysis of PTP1B Inhibitors from Cleistocalyx operculatus Leaves and Their Effect on Glucose Uptake

  2024cites this paper
• Potential protein tyrosine phosphatase 1B and α-glucosidase inhibitory flavonoids from Erythrina variegata: Experimental and computational results

  2024cites this paper
• Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity

  2022cites this paper
• The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

  2021cites this paper
• A Library of Thiazolidin‐4‐one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt To Discover Novel Antidiabetic Agents

  2020cites this paper
• 5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors.

  2020cites this paper
• An overview of computer-aided drug design tools and recent applications in designing of antidiabetic agents.

  2020cites this paper
• A Preliminary Study on the Effect and Mechanism of Breviscapine for Improving Insulin Resistance in HepG2 Cells.

  2020cites this paper
• Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.

  2018cites this paper
• Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress.

  2017cites this paper
• Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway.

  2017cites this paper
• Glucose Uptake Activities of Bis (2, 3-Dibromo-4, 5-Dihydroxybenzyl) Ether, a Novel Marine Natural Product from Red Alga Odonthaliacorymbifera with Protein Tyrosine Phosphatase 1B Inhibition, In Vitro and In Vivo

  2016cites this paper
• Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.

  2015cites this paper
• Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

  2013cites this paper
• Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.

  2013cites this paper
• Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation*

  2013cites this paper
• Molecular Dynamics Approach to Probe the Allosteric Inhibition of PTP1B by Chlorogenic and Cichoric Acid

  2012cites this paper
• Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.

  2012cites this paper
• Regulation of Signaling at Regions of Cell-Cell Contact by Endoplasmic Reticulum-Bound Protein-Tyrosine Phosphatase 1B

  2012cites this paper
• Synthesis and Biological Evaluation of 2,4,6‐Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors

  2012cites this paper
• Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.

  2011cites this paper
• Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.

  2011cites this paper
• Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome?

  2010cites this paper
• Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.

  2010cites this paper
• LXR (cid:1) activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins

  2009cites this paper
• Mechanisms of Diet-induced Dyslipidemia and Insulin Resistance: Role of Chronic LXR Activation

  2009cites this paper
• Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.

  2009cites this paper
• LXR (cid:1) activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins

  2009cites this paper
• LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.

  2009cites this paper
• Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

  2008cites this paper
• Structure‐Based Optimization of Protein Tyrosine Phosphatase‐1 B Inhibitors: Capturing Interactions with Arginine 24

  2008cites this paper
• A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.

  2008cites this paper
• Hyrtiosal, a PTP1B Inhibitor from the Marine Sponge Hyrtios erectus, Shows Extensive Cellular Effects on PI3K/AKT Activation, Glucose Transport, and TGFβ/Smad2 Signaling

  2007cites this paper
• The role of fluorine in medicinal chemistry

  2007cites this paper
• Docking Studies on Formylchromone Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors

  2007cites this paper
• Enantioselective synthesis of protected L-4-[sulfonamido(difluoromethyl)]phenylalanine and L-4-[sulfonamido(methyl)]phenylalanine and an examination of hexa- and tripeptide platforms for evaluating pTyr mimics for PTP1B inhibition.

  2006cites this paper
• Proteomic analysis of differential protein expression in atherosclerosis

  2006cites this paper
• Early Obesity and Age‐Related Mimicry of Metabolic Syndrome in Female Mice with Sex Hormonal Imbalances

  2006cites this paper
• Protein tyrosine phosphatase 1B regulates TGF beta 1-induced Smad2 activation through PI3 kinase-dependent pathway.

  2006cites this paper
• PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.

  2006cites this paper
• Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db/db mice.

  2006cites this paper
• Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

  2006cites this paper
• Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors

  2005cites this paper
• Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies.

  2005cites this paper
• Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice.

  2005cites this paper
• Sensitivity of Protein Tyrosine Phosphatase Activity to the Redox Environment, Cytochrome c, and Microperoxidase

  2005cites this paper
• Protein tyrosine phosphatases and their inhibitors.

  2005cites this paper
• TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c‐Src kinase and ERK activation

  2005cites this paper
• Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s).

  2005cites this paper
• Therapeutic strategies for targeting PTP1B in diabetes

  2005cites this paper
• Beyond the Metabolic Function of PTP1B

  2004cites this paper
• Recent advances in protein tyrosine phosphatase 1B inhibitors

  2004cites this paper
• Cyclic amp-dependent protein kinase : a potential target for actions of vanadium

  2004cites this paper
• Identification of genes contributing to the obese yellow A phenotype: caloric restriction, genotype, diet genotype interactions

  2004cites this paper
• Current and emerging therapies for type 2 diabetes.

  2004cites this paper
• Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.

  2004cites this paper
• Borko genotype interactions phenotype : caloric restriction , genotype , diet × vy A Identification of genes contributing to the obese yellow

  2004cites this paper
• Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.

  2004cites this paper
• Modulation of insulin action

  2004cites this paper