Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity

•  Gene deletion studies revealed that membrane proteins stomatin and STOML3, as well as the acid‐sensing ion channels ASIC2 and ASIC3, regulate mechanosensory transduction. •  Both stomatin and STOML3 interact with ASIC proteins and we asked if deletion of two interacting proteins has a more than additive effect on the mechanosensitivity of cutaneous sensory afferents. •  A detailed electrophysiological comparison of sensory afferent phenotypes observed in asic3−/−:stomatin−/−, asic3−/−:stoml3−/− and asic2−/−:stomatin−/− mutant mice compared to their respective single gene mutants revealed especially strong effects on the mechanosensitivity of thinly myelinated mechanonociceptors in double mutants. •  Deletion of the asic3 gene or pharmacological blockade of this channel decreased adaptation rates specifically in rapidly adapting mechanoreceptors, an effect not exacerbated by deletion of stomatin‐domain genes. •  This study reveals that loss of stomatin–ASIC interactions can have profound effects on mechanosensitivity in specific subsets of skin afferents; interfering with such interactions could have potential for treating mechanical pain.

• Publication year

  2013

• Venue

  Journal of Physiology

• Publication date

  2013-08-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2013.261180PMID 23959680PMCID 3853495
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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