Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Nutritional Biochemistry

• Publication date

  2016-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jnutbio.2015.09.014PMID 27260468PMCID PMC4895202
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses

  2015cited by this paper
• Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway.

  2015cited by this paper
• Epidemiology of skin cancer.

  2014cited by this paper
• Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

  2014cited by this paper
• Natural compounds in epigenetics: a current view.

  2014cited by this paper
• Cancer statistics, 2014

  2014cited by this paper
• Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

  2014influential reference
• Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals.

  2014cited by this paper
• Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

  2014influential reference
• Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway

  2014influential reference
• Plant-derived epigenetic modulators for cancer treatment and prevention.

  2014cited by this paper
• Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival

  2014cited by this paper
• Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.

  2013influential reference
• Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition.

  2013cited by this paper
• Cancer Epigenetics: New Therapies and New Challenges

  2013cited by this paper
• Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.

  2013cited by this paper
• Chromatin proteins and modifications as drug targets

  2013cited by this paper
• The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer☆

  2013cited by this paper
• The emerging role of the Nrf2–Keap1 signaling pathway in cancer

  2013cited by this paper
• Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

  2013cited by this paper
• Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice.

  2013cited by this paper
• Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

  2013influential reference
• Epigenetic Cancer Prevention Mechanisms in Skin Cancer

  2013influential reference
• Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.

  2013influential reference
• Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells

  2013cited by this paper
• Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice

  2013cited by this paper
• The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

  2013cited by this paper
• Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators.

  2012cited by this paper
• Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes.

  2012cited by this paper
• Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells

  2012cited by this paper
• Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease

  2012cited by this paper
• A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.

  2012cited by this paper
• CA : A Cancer Journal for Clinicians

  2011cited by this paper
• Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice.

  2011cited by this paper
• Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.

  2011influential reference
• Small molecule modulators of antioxidant response pathway.

  2011cited by this paper
• Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

  2011cited by this paper
• Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma

  2011cited by this paper
• Cancer epigenetics: linking basic biology to clinical medicine

  2011influential reference
• Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

  2010cited by this paper
• Cytotoxic triterpenoids from the stems of Microtropis japonica.

  2009cited by this paper
• The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

  2009cited by this paper
• Ursolic acid: an anti- and pro-inflammatory triterpenoid.

  2008cited by this paper
• Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

  2008cited by this paper
• Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells

  2007cited by this paper
• Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats.

  2007cited by this paper
• Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

  2006cited by this paper
• Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart.

  2006cited by this paper
• Oxidative stress in the pathogenesis of skin disease.

  2006cited by this paper
• Anticancer activities of histone deacetylase inhibitors

  2006cited by this paper
• Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

  2006cited by this paper
• Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

  2005cited by this paper
• Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase‐3 activation in M4Beu melanoma cells

  2005cited by this paper
• The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: The JB6 model is predictive

  2004cited by this paper
• Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats.

  2004cited by this paper
• Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation

  2003cited by this paper
• Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

  2003cited by this paper
• Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes.

  2003cited by this paper
• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  2002cited by this paper
• DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

  2002cited by this paper
• The epidemiology of skin cancer

  2002cited by this paper
• The role of AP-1, NF-кB and ROS/ NOS in skin carcinogenesis: The JB6 model is predictive

  2002cited by this paper
• Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

  2001cited by this paper
• Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.

  2001cited by this paper
• Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

  1997cited by this paper
• Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.

  1994cited by this paper
• Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.

  1994cited by this paper
• Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

  1986cited by this paper
• Advances in Experimental Medicine and Biology

  1973cited by this paper

• Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma

  2026cites this paper
• Investigating the Epigenetic Therapeutic Potential of Natural Compounds in Cancer

  2025cites this paper
• Ursolic acid suppresses gastric cancer by targeting the miR-27a-3p/Wnt/β-catenin signaling axis

  2025cites this paper
• Effects of Ursolic Acid on Immune Function and Antioxidative Capacity in Weaned Rabbits

  2025cites this paper
• The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy

  2025cites this paper
• Exploring the links between polyphenols, Nrf2, and diabetes: A review.

  2025cites this paper
• Simultaneous quantitation of pentacyclic triterpenoids in fruit peels using liquid chromatography-single quadrupole mass spectrometry.

  2025cites this paper
• The Nutrigenomic Effect of Mela Rosa Marchigiana Callus Extract on Cellular Senescence: Insight From a Preliminary In Vitro Study

  2025cites this paper
• Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception.

  2024cites this paper
• Ursolic Acid as a Protective Agent Against UVB-Induced Metabolic and Epigenetic Alterations in Human Skin Keratinocytes: An Omics-Based Study.

  2024cites this paper
• Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health

  2024cites this paper
• Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management

  2024influential citation
• The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers

  2024cites this paper
• Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agents.

  2023cites this paper
• Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease

  2023cites this paper
• Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: Structure, function and design.

  2023cites this paper
• Fruit Extract, Rich in Polyphenols and Flavonoids, Modifies the Expression of DNMT and HDAC Genes Involved in Epigenetic Processes

  2023cites this paper
• Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals

  2023cites this paper
• Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

  2023cites this paper
• Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks

  2023cites this paper
• Ursolic acid: biological functions and application in animal husbandry

  2023cites this paper
• Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer’s Disease: Recent Trends and Future Development

  2023cites this paper
• Potential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors

  2023cites this paper
• Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress

  2022cites this paper
• DNA Methylome and Transcriptome Study of Triterpenoid CDDO in TPA-Mediated Skin Carcinogenesis Model

  2022cites this paper
• NRF2, a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer

  2022cites this paper
• PTEN‐knockout regulates metabolic rewiring and epigenetic reprogramming in prostate cancer and chemoprevention by triterpenoid ursolic acid

  2022cites this paper
• Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury

  2022influential citation
• Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes

  2022cites this paper
• Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer

  2022cites this paper
• The Therapeutic Potential of Kaemferol and Other Naturally Occurring Polyphenols Might Be Modulated by Nrf2-ARE Signaling Pathway: Current Status and Future Direction

  2022cites this paper
• Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates

  2022cites this paper
• Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

  2021cites this paper
• Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds.

  2021cites this paper
• Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.

  2021cites this paper
• Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans.

  2021cites this paper
• Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

  2021cites this paper
• Inhibition of DNA methylation de‐represses peroxisome proliferator‐activated receptor‐γ and attenuates pulmonary fibrosis

  2021cites this paper
• Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

  2021cites this paper
• Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

  2021cites this paper
• Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

  2021cites this paper
• Protective effects of natural compounds against oxidative stress in ischemic diseases and cancers via activating the Nrf2 signaling pathway: A mini review

  2020cites this paper
• Epigenetics/Epigenomics and Prevention of Early Stages of Cancer by Isothiocyanates

  2020cites this paper
• Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals

  2020cites this paper
• Natural Nrf2 Modulators for Skin Protection

  2020cites this paper
• New vistas in malignant mesothelioma: MicroRNA architecture and NRF2/MAPK signal transduction.

  2020cites this paper
• Epigenome, Transcriptome, and Protection by Sulforaphane at Different Stages of UVB-Induced Skin Carcinogenesis

  2020cites this paper
• Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells.

  2020cites this paper
• Epigenetics/Epigenomics of Triterpenoids in Cancer Prevention and in Health.

  2020cites this paper
• Redox Signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals.

  2020cites this paper
• Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats

  2020cites this paper
• Cranberry as a Promising Natural Source of Potential Nutraceuticals with Anticancer Activity.

  2019cites this paper
• Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.

  2019cites this paper
• Epicatechin Reduces Spatial Memory Deficit Caused by Amyloid-β25–35 Toxicity Modifying the Heat Shock Proteins in the CA1 Region in the Hippocampus of Rats

  2019cites this paper
• Molecular Carcinogenesis

  2019cites this paper
• Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway

  2019cites this paper
• Dietary and Lifestyle Factors in Epigenetic Regulation of Cancer

  2019cites this paper
• Ursolic Acid Reverses the Chemoresistance of Breast Cancer Cells to Paclitaxel by Targeting MiRNA-149-5p/MyD88

  2019cites this paper
• Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

  2018cites this paper
• The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP‐C1 prostate cells

  2018cites this paper
• Cis-3-O-p-hydroxycinnamoyl Ursolic Acid Induced ROS-Dependent p53-Mediated Mitochondrial Apoptosis in Oral Cancer Cells

  2018cites this paper
• Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells

  2018cites this paper
• Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways.

  2017cites this paper
• Effects of EGCG on LPS-induced elevation of inflammatory factors in human gingival fibroblasts and functional mechanisms

  2017cites this paper
• In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes.

  2017cites this paper
• Phytochemicals in Traditional Chinese Herbal Medicine: Cancer Prevention and Epigenetics Mechanisms

  2017cites this paper
• Correction to: In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro

  2017cites this paper
• Secreted frizzled-related protein 2-mediated cancer events: Friend or foe?

  2017cites this paper
• Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation.

  2017cites this paper
• Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics.

  2016cites this paper