Boolean gates on actin filaments

Actin is a globular protein which forms long polar filaments in the eukaryotic cytoskeleton. Actin networks play a key role in cell mechanics and cell motility. They have also been implicated in information transmission and processing, memory and learning in neuronal cells. The acting filaments have been shown to support propagation of voltage pulses. Here we apply a coupled nonlinear transmission line model of actin filaments to study interactions between voltage pulses. By assigning a logical {\sc Truth} to the presence of a voltage pulses in a given location of the actin filament, and {\sc False} to the pulse's absence we represent digital information transmission along these filaments. When two pulses, representing Boolean values of input variables, interact, then they can facilitate or inhibit further propagation of each other. We explore this phenomenon to construct Boolean logical gates and a one-bit half-adder with interacting voltage pulses. We discuss implications of these findings on cellular process and technological applications.

• Publication year

  2015

• Venue

  arXiv.org

• Publication date

  2015-06-30

• Fields of study

  Physics, Computer Science

• Identifiers
  DOI 10.1016/J.PHYSLETA.2015.09.024arXiv 1506.09044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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