Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2013-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.00490.2012PMID 23462816PMCID PMC3625779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific

  2012cited by this paper
• ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

  2011cited by this paper
• Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and diabetes: a meta-analysis of placebo-controlled clinical trials.

  2011cited by this paper
• ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension.

  2011cited by this paper
• Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays.

  2011cited by this paper
• Biliverdin protects against the deterioration of glucose tolerance in db/db mice

  2011cited by this paper
• Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension

  2010cited by this paper
• Angiotensin I–Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

  2010cited by this paper
• Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets

  2010cited by this paper
• Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7)

  2010cited by this paper
• Angiotensin II Reduces Mitochondrial Content in Skeletal Muscle and Affects Glycemic Control

  2009cited by this paper
• Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus.

  2009cited by this paper
• Decreased expression of angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression.

  2009cited by this paper
• Chronic infusion of angiotensin-(1-7) improves insulin resistance and hypertension induced by a high-fructose diet in rats.

  2009cited by this paper
• Angiotensin II Type 1 Receptor–Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice

  2009cited by this paper
• Crosstalk between insulin and angiotensin II signalling systems.

  2009cited by this paper
• Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression

  2008cited by this paper
• Angiotensin-Converting Enzyme 2 Overexpression in the Subfornical Organ Prevents the Angiotensin II–Mediated Pressor and Drinking Responses and Is Associated With Angiotensin II Type 1 Receptor Downregulation

  2008cited by this paper
• Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.

  2008cited by this paper
• The sweeter side of ACE2: Physiological evidence for a role in diabetes

  2008cited by this paper
• Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression

  2008cited by this paper
• Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease.

  2008cited by this paper
• Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice

  2008cited by this paper
• Genetically altered animal models for Mas and angiotensin‐(1–7)

  2008cited by this paper
• ACE2: a new target for cardiovascular disease therapeutics.

  2007cited by this paper
• Improvement of insulin sensitivity by antagonism of the renin-angiotensin system.

  2007cited by this paper
• Association of Oxidative Stress, Insulin Resistance, and Diabetes Risk Phenotypes

  2007cited by this paper
• Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice.

  2007cited by this paper
• Vasoactive drugs enhance pancreatic islet blood flow, augment insulin secretion and improve glucose tolerance in female rats.

  2007cited by this paper
• Peroxisome Proliferator–Activated Receptor α/γ Dual Agonist Tesaglitazar Attenuates Diabetic Nephropathy in db/db Mice

  2007cited by this paper
• Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes.

  2006cited by this paper
• Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.

  2006cited by this paper
• Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes*

  2004cited by this paper
• Immunohistochemical localization of angiotensin II in the mouse pancreas

  2004cited by this paper
• Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat.

  2004cited by this paper
• Angiotensin II Type-1 Receptor Blocker Valsartan Enhances Insulin Sensitivity in Skeletal Muscles of Diabetic Mice

  2004cited by this paper
• Sarcosine1,glycine8 angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist.

  2003cited by this paper
• Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy

  2003cited by this paper
• Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool.

  2001cited by this paper
• A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

  2000cited by this paper
• The tissue renin-angiotensin system in human pancreas.

  1999cited by this paper
• Expression and localization of the renin-angiotensin system in the rat pancreas.

  1999cited by this paper
• Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats

  1998cited by this paper
• The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors.

  1998cited by this paper
• Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents.

  1997cited by this paper
• Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.

  1997cited by this paper
• Pancreatic islet blood flow in normal and obese-hyperglycemic (ob/ob) mice.

  1996cited by this paper
• Evidence for an intrinsic angiotensin system in the canine pancreas.

  1991cited by this paper
• Seen from E. A.--Three International Episodes.Herbert Feis

  1947cited by this paper
• Journal of Visualized Experiments www.jove.com Video Article A Method for Murine Islet Isolation and

  year unknowncited by this paper

• Association of genetic variants with the progression of COVID-19 symptoms in diabetic patients: a systematic review and in silico protein interaction analysis.

  2025cites this paper
• Molecular Dissection of the Role of ACE2 in Glucose Homeostasis.

  2025cites this paper
• Protective effects of melatonin on AT1, ACE2, and Mas genes expression in induced diabetic aortic rats

  2024cites this paper
• UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension

  2024cites this paper
• Potential Effects of Hyperglycemia on SARS-CoV-2 Entry Mechanisms in Pancreatic Beta Cells

  2024cites this paper
• Normal β-Cell Glut2 Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice

  2023cites this paper
• Angiotensin-(1-7) Improves Islet β-cell Dedifferentiation by Activating PI3K/Akt/FoxO1 Pathway.

  2023cites this paper
• Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model

  2023cites this paper
• Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2.

  2022cites this paper
• Covid-19 infection in children and adolescents and its association with type 1 diabetes mellitus (T1d) presentation and management

  2022cites this paper
• An insight into the mechanisms of COVID-19, SARS-CoV2 infection severity concerning β-cell survival and cardiovascular conditions in diabetic patients

  2022cites this paper
• Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism.

  2021cites this paper
• Acute Pancreatitis in Children.

  2021cites this paper
• The Many Faces of Innate Immunity in SARS-CoV-2 Infection

  2021cites this paper
• Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update

  2021cites this paper
• ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders.

  2021cites this paper
• COVID-19 and gastrointestinal system: A brief review

  2021influential citation
• Epigenetic modifications of the renin-angiotensin system in cardiometabolic diseases.

  2021cites this paper
• Endocrine Significance of SARS-CoV-2’s Reliance on ACE2

  2020cites this paper
• Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell

  2020cites this paper
• DMSO_A_257797 2843..2853

  2020cites this paper
• Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice

  2020cites this paper
• Association between Acute Pancreatitis and COVID-19: Could Pancreatitis Be the Missing Piece of the Puzzle about Increased Mortality Rates?

  2020cites this paper
• ACE2 as therapeutic agent.

  2020cites this paper
• The Perfect Storm: COVID-19 Health Disparities in US Blacks

  2020cites this paper
• Endoplasmic Reticulum (ER) Stress in Part Mediates Effects of Angiotensin II in Pancreatic Beta Cells

  2020cites this paper
• The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis.

  2019cites this paper
• Pancreatic AT1aR Deficiency Decreases Insulin Secretion in Obese C57BL/6 Mice

  2019cites this paper
• The Angiotensin-(1-7) Axis: Formation and Metabolism Pathways

  2019cites this paper
• Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells.

  2018cites this paper
• Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.

  2018cites this paper
• Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2

  2017cites this paper
• Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)

  2017cites this paper
• The Renin Angiotensin System and Diabetes

  2017cites this paper
• Peptidases and the Renin-Angiotensin System: The Alternative Angiotensin-(1-7) Cascade

  2017cites this paper
• Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

  2017cites this paper
• The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance.

  2017cites this paper
• The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis

  2016cites this paper
• High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice.

  2016cites this paper
• Regulation of insulin sensitivity, insulin production, and pancreatic β cell survival by angiotensin-(1-7) in a rat model of streptozotocin-induced diabetes mellitus.

  2015cites this paper
• Regulation of pancreatic beta-cell function by the renin-angiotensin system in type 2 diabetes

  2015cites this paper
• ACE2 and Glycemic Control

  2015cites this paper
• Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice

  2015influential citation
• Modulation of glucose metabolism by the renin-angiotensin-aldosterone system.

  2015cites this paper
• ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice.

  2015cites this paper
• ACE2 deficiency shifts energy metabolism towards glucose utilization.

  2015cites this paper
• Activation of angiotensin type 2 receptors partially ameliorates streptozotocin-induced diabetes in male rats by islet protection.

  2014cites this paper
• Glucolipotoxicité dans les cellules bêta pancréatiques

  2014cites this paper
• Angiotensin II Mediates Angiotensin Converting Enzyme Type 2 Internalization and Degradation Through an Angiotensin II Type I Receptor–Dependent Mechanism

  2014cites this paper
• Mas and Its Related G Protein–Coupled Receptors, Mrgprs

  2014cites this paper
• Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

  2014cites this paper
• Modulation of the action of insulin by angiotensin-(1-7).

  2014cites this paper
• Response to Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233

  2013cites this paper
• Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233

  2013cites this paper
• The role of renin-angiotensin system in cellular differentiation: implications in pancreatic islet cell development and islet transplantation.

  2013cites this paper
• The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs.

  2013influential citation
• Angiotensin converting enzyme 2: A new important player in the regulation of glycemia

  2013cites this paper
• Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator.

  2013cites this paper
• World Journal of Diabetes

  year unknowncites this paper