The O‐linked N‐acetylglucosamine modification in cellular signalling and the immune system

No abstract is available for this paper.

• Publication year

  2008

• Venue

  EMBO Reports

• Publication date

  2008-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/embor.2008.129PMID 18617890PMCID PMC2515212
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatic Glucose Sensing via the CREB Coactivator CRTC2

  2008influential reference
• A strategy to discover inhibitors of O-linked glycosylation.

  2008cited by this paper
• Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

  2008cited by this paper
• o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells.

  2008cited by this paper
• Requirement for O‐linked N‐acetylglucosaminyltransferase in lymphocytes activation

  2007cited by this paper
• Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins.

  2007cited by this paper
• Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

  2007cited by this paper
• Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

  2007influential reference
• O-GlcNAc modification in diabetes and Alzheimer's disease.

  2007cited by this paper
• Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates.

  2006cited by this paper
• Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

  2006cited by this paper
• Cell signaling, the essential role of O-GlcNAc!

  2006cited by this paper
• Protein O-GlcNAc Modulates Motility-associated Signaling Intermediates in Neutrophils*

  2005cited by this paper
• Discovery of O-GlcNAc transferase inhibitors.

  2005cited by this paper
• The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code"

  2005cited by this paper
• Characterization of the Histone Acetyltransferase (HAT) Domain of a Bifunctional Protein with Activable O-GlcNAcase and HAT Activities*♦

  2004cited by this paper
• O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress.

  2004cited by this paper
• Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability

  2004cited by this paper
• Neutrophils Exhibit Rapid Agonist-induced Increases in Protein-associated O-GlcNAc*

  2004cited by this paper
• The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin α

  2004influential reference
• Roles of the Tetratricopeptide Repeat Domain in O-GlcNAc Transferase Targeting and Protein Substrate Specificity*

  2003cited by this paper
• Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene.

  2003cited by this paper
• Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase

  2003cited by this paper
• Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine*

  2003cited by this paper
• Identification and Cloning of a Novel Family of Coiled-coil Domain Proteins That Interact with O-GlcNAc Transferase*

  2003cited by this paper
• Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation.

  2002cited by this paper
• Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.

  2002cited by this paper
• Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians.

  2002cited by this paper
• Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

  2002cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2002cited by this paper
• Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors*

  2002cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2001cited by this paper
• O-linked N-acetylglucosamine and cancer: messages from the glycosylation of c-Myc.

  2001cited by this paper
• Glycan‐dependent signaling: O‐linked N‐acetylglucosamine

  2001influential reference
• Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase.

  2001cited by this paper
• Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activity.

  2001cited by this paper
• Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1

  2001cited by this paper
• The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

  2000cited by this paper
• Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta.

  2000cited by this paper
• Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells.

  1999cited by this paper
• Elevated O-LinkedN-Acetylglucosamine Metabolism in Pancreatic β-Cells

  1999cited by this paper
• Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

  1998cited by this paper
• Modulation of O-LinkedN-Acetylglucosamine Levels on Nuclear and Cytoplasmic Proteins in Vivo Using the PeptideO-GlcNAc-β-N-acetylglucosaminidase InhibitorO-(2-Acetamido-2-deoxy-dglucopyranosylidene)amino-N-phenylcarbamate*

  1998influential reference
• Dynamic Glycosylation of Nuclear and Cytosolic Proteins

  1997influential reference
• O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats*

  1997cited by this paper
• c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas (*)

  1995cited by this paper
• RNA polymerase II is a glycoprotein. Modification of the COOH-terminal domain by O-GlcNAc.

  1993cited by this paper
• Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteins.

  1991cited by this paper
• Nuclear pore complex glycoproteins contain cytoplasmically disposed O- linked N-acetylglucosamine

  1987cited by this paper

• O-GlcNAcylation and immune cell signaling: A review of known and a preview of unknown

  2024cites this paper
• Hexosamine biosynthesis and related pathways, protein N-glycosylation and O-GlcNAcylation: their interconnection and role in plants

  2024cites this paper
• Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics

  2024cites this paper
• O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

  2022cites this paper
• The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategies.

  2021cites this paper
• PPAR Modulation Through Posttranslational Modification Control

  2021cites this paper
• Impairment of a cyanobacterial glycosyltransferase that modifies a pilin results in biofilm development

  2021cites this paper
• Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors

  2020cites this paper
• A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens

  2020cites this paper
• Immunomodulatory Effects of N-Acetyl Chitooligosaccharides on RAW264.7 Macrophages

  2020cites this paper
• Hyperglycemia-Induced Aberrant Cell Proliferation; A Metabolic Challenge Mediated by Protein O-GlcNAc Modification

  2019cites this paper
• A mouse model for functional dissection of TAB1 O-GlcNAcylation

  2019cites this paper
• A mouse model for functional dissection of TAB1 O-GlcNAcylation.

  2019cites this paper
• O‐Glycosylation with O‐linked &bgr;‐N‐acetylglucosamine increases vascular contraction: Possible modulatory role on Interleukin‐10 signaling pathway

  2018cites this paper
• Regulation of the Hippo signaling pathway by ubiquitin modification

  2018cites this paper
• Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation

  2018cites this paper
• Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise

  2018cites this paper
• E3 ubiquitin ligases in cancer and implications for therapies

  2017cites this paper
• This information is current as-GlcNAc Transferase O Targeting Pathogenesis of Multiple Sclerosis by Differentiation and Is Associated with MicroRNA-15 b Suppresses Th

  2017cites this paper
• NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage

  2017cites this paper
• Pro-Dopamine Regulator – (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS)

  2017cites this paper
• Immunometabolism in early and late stages of rheumatoid arthritis

  2017cites this paper
• Palestinian Arab ethnicity is associated with an adverse metabolic phenotype.

  2017cites this paper
• Regulation of AMPA Receptor Trafficking by Protein Ubiquitination

  2017cites this paper
• Pro-Dopamine Regulator-( KB 220 ) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome ( RDS ) Mini-review

  2017influential citation
• Theoretical pKa prediction of the α-phosphate moiety of uridine 5′-diphosphate-GlcNAc

  2017cites this paper
• MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase

  2017cites this paper
• Profiling of Protein O-GlcNAcylation in Murine CD8+ Effector- and Memory-like T Cells.

  2017cites this paper
• Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

  2016cites this paper
• Insights into APC/C: from cellular function to diseases and therapeutics

  2016cites this paper
• Systematic approaches to identify E3 ligase substrates

  2016cites this paper
• Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

  2016cites this paper
• Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells

  2016cites this paper
• Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells

  2016cites this paper
• Roles of O-GlcNAc in chronic diseases of aging.

  2016cites this paper
• Influence de l'ubiquitylation initiale des substrats SH3 sur leur régulation par la ligase Itch

  2016influential citation
• The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia formation via ubiquitylation of CSPP-L

  2016cites this paper
• Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector‐mediated subversion of host innate immune pathways

  2015cites this paper
• NOS1AP O-GlcNAc Modification Involved in Neuron Apoptosis Induced by Excitotoxicity

  2015cites this paper
• The early phase of the vaccinia virus replication induces cytokine gene expression in macrophages

  2015cites this paper
• Ubiquitylation: its role and medical significance

  2015cites this paper
• Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets

  2014cites this paper
• MATERIALS AND METHODS Animal model of trauma and hemorrhage

  2014influential citation
• Expression of neddylation-related proteins in melanoma cell lines and the effect of neddylation on melanoma proliferation

  2014cites this paper
• Immunohistochemical Analysis of the Ubiquitin Proteasome System and Autophagy Lysosome System Induced After Traumatic Intracranial Injury: Association With Time Between the Injury and Death

  2014cites this paper
• Innovative Therapies in Ewing Sarcoma

  2014cites this paper
• Community Structure Detection for Overlapping Modules through Mathematical Programming in Protein Interaction Networks

  2014cites this paper
• Regulation of hepatic insulin receptor activity following injury.

  2014cites this paper
• O-GlcNAcylation as a novel ammonia-induced posttranslational protein modification in cultured rat astrocytes

  2014influential citation
• Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis*

  2013cites this paper
• Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.

  2013influential citation
• The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy.

  2013cites this paper
• Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

  2013cites this paper
• p38 and OGT Sequestration into Viral Inclusion Bodies in Cells Infected with Human Respiratory Syncytial Virus Suppresses MK2 Activities and Stress Granule Assembly

  2012cites this paper
• O-GlcNAc modification affects the ATM-mediated DNA damage response.

  2012cites this paper
• O-GlcNAc modification of the anti-malarial vaccine candidate PfAMA1: in silico-defined structural changes and potential to generate a better vaccine

  2012cites this paper
• Leukocyte O-GlcNAcylation : a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus?

  2012influential citation
• PARP1 expression in breast cancer and effects of its inhibition in preclinical models

  2012cites this paper
• Ubiquitin initiates sorting of Golgi and plasma membrane proteins into the vacuolar degradation pathway

  2012cites this paper
• O-GlcNAcylation and oxidation of proteins: is signalling in the cardiovascular system becoming sweeter?

  2012cites this paper
• Exploring leukocyte O-GlcNAcylation as a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus.

  2012cites this paper
• O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

  2012cites this paper
• Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response.

  2011cites this paper
• Mass Spectrometry of Amino Acids and Proteins

  2011cites this paper
• Serine residues in the LAT adaptor are essential for TCR‐dependent signal transduction

  2011cites this paper
• Rôle des protéines de choc thermique dans la régulation du facteur de transcription HIF

  2011cites this paper
• O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis.

  2010cites this paper
• Concurrently using rosiglitazone prevents glucosamine‐induced islet β‐Cell apoptosis and dysfunction

  2010cites this paper
• The membrane receptors guanylyl cyclase‐A and ‐B undergo distinctive changes in post‐translational modification during brain development

  2010cites this paper
• Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.

  2010cites this paper
• Carbohydrate biomarkers for future disease detection and treatment

  2010cites this paper
• The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine.

  2010cites this paper
• Deactivation of STAT6 through Serine 707 Phosphorylation by JNK*

  2010cites this paper
• Modulation of transcription factor function by O-GlcNAc modification.

  2010cites this paper
• GlaxoSmithKline Award Lecture. The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease.

  2010cites this paper
• RATIONAL DESIGN AND SYNTHESIS OF CHEMICAL PROBES FOR O-GLCNACASE AND OGT

  2010cites this paper
• Genomic methods for studying the post-translational regulation of transcription factors

  2010cites this paper
• Chapter 31 Protein Gel Staining Methods

  2009cites this paper
• Protein Modifications as Potential Biomarkers in Breast Cancer

  2009cites this paper
• Protein gel staining methods: an introduction and overview.

  2009cites this paper
• Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)

  2009cites this paper