Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis.

BACKGROUND AND AIMS Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. METHODS We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively. RESULTS We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMD = 0.25, 95%CI: 0.07-0.42, p = 0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (OR = 1.45; 95% CI, 0.92-2.29, p = 0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMD = 0.49; 95% CI, 0.19-0.80, p = 0.001). CONCLUSIONS SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.

• Publication year

  2019

• Venue

  Atherosclerosis

• Publication date

  2019-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.atherosclerosis.2019.01.006PMID 30708178
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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