Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Methods in molecular biology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-4939-8796-2_17PMID 30725419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey

  2015cited by this paper
• Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.

  2010cited by this paper
• Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.

  1999cited by this paper
• Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.

  1997cited by this paper
• Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.

  1997cited by this paper
• Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients.

  1996cited by this paper
• Anticancer efficacy of methioninase in vivo.

  1996cited by this paper
• Synergistic Effect of Methionine‐depleting Total Parenteral Nutrition with 5‐Fluorouracil on Human Gastric Cancer: A Randomized, Prospective Clinical Trial

  1995cited by this paper
• The Preparation of Endotoxin-Free L-Methionine-α-deamino-γ-mercaptomethane-lyase (L-Methioninase) from Pseudomonas putida

  1993cited by this paper
• The preparation of endotoxin-free L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Pseudomonas putida.

  1993cited by this paper
• Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo.

  1993cited by this paper
• Antitumor effect of methionine‐depleting total parenteral nutrition with doxorubicin administration on yoshida sarcoma‐bearing rats

  1992cited by this paper
• o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids.

  1983cited by this paper
• Reversible growth arrest in simian virus 40-transformed human fibroblasts.

  1980cited by this paper

• Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.

  2025cites this paper
• Catabolic rewiring in cancer impacts dietary interventions

  2025cites this paper
• Methionine restriction and mimetics to ameliorate human aging and disease.

  2025cites this paper
• Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic Potential

  2025cites this paper
• A review on L-methioninase in cancer therapy: Precision targeting, advancements and diverse applications for a promising future.

  2024cites this paper
• Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: Progress, challenges, and opportunities: A review.

  2024cites this paper
• Niche-Aware Metagenomic Screening for Enzyme Methioninase Illuminates Its Contribution to Metabolic Syntrophy

  2024cites this paper
• The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality

  2023cites this paper
• Dietary methionine starvation impairs acute myeloid leukemia progression.

  2022cites this paper
• Microbial enzymes: the role of enzyme in cancer therapy

  2022cites this paper
• Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers

  2022cites this paper
• Screening, characterization and anti-cancer application of purified intracellular MGL.

  2022cites this paper
• Targeting amino acid metabolism in cancer.

  2022cites this paper
• Predictive markers for efficiency of the amino-acid deprivation therapies in cancer

  2022cites this paper
• Effects of metabolic cancer therapy on tumor microenvironment

  2022cites this paper
• Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases.

  2022cites this paper
• Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids.

  2021cites this paper
• A genetic model of methionine restriction extends Drosophila health- and lifespan

  2021cites this paper
• A planetary health perspective on synthetic methionine.

  2021cites this paper
• Microbial therapeutic enzymes: A promising area of biopharmaceuticals

  2021cites this paper
• The Molecular Link from Diet to Cancer Cell Metabolism.

  2020cites this paper
• Microbial enzymes for deprivation of amino acid metabolism in malignant cells: biological strategy for cancer treatment

  2020cites this paper
• The Molecular Link from Diet to Cancer Cell Metabolism.

  2020cites this paper
• Oncology Therapeutics Targeting the Metabolism of Amino Acids

  2020cites this paper
• Methionine metabolism in health and cancer: a nexus of diet and precision medicine

  2019cites this paper