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Glutathione S-Transferase Genotype Protects Against In Utero Tobacco Linked Lung Function Deficits.

L. Owens,I. Laing,Jasminka Murdzoska,G. Zhang,S. Turner,P. L. Le Souëf

Published 2019 in American Journal of Respiratory and Critical Care Medicine

ABSTRACT

Rationale In utero tobacco exposure is associated with reduced lung function from infancy. Anti-oxidant enzymes from the glutathione-s-transferase (GST) family may protect against these lung function deficits. Objectives: (1) Assess the long-term effect of in utero smoke exposure on lung function into adulthood. (2) Assess whether GSTT1 and GSTM1 active genotypes have longterm protective effects on lung function. Methods: In this longitudinal study, based on a normal population (n=253), lung function was measured during infancy and at 6, 11, 18 and 24 years. GSTM1 and GSTT1 genotype was analysed in a subgroup (n= 179). Lung function was assessed longitudinally from 6 to 24 years (n=144). Main Results Exposure to maternal in utero tobacco was associated with lower FEV1 and FVC longitudinally from 6 to 24 years (mean difference - 3.87% predicted, p=0.021; -3.35% predicted, p=0.035, respectively). Among those homozygous for the GSTM1 null genotype, in utero tobacco exposure was associated with lower FEV1 and FVC compared with those with no in utero tobacco exposure (mean difference -6.2% predicted, p=0.01; -4.7% predicted, p=0.043 respectively). For those with GSTM1 active genotype, there was no difference in lung function whether exposed to maternal in utero tobacco or not. In utero tobacco exposure was associated with deficits in lung function among those with both GSTT1 null and GSTT1 active genotypes. Conclusions Certain GST genotypes may have protective effects against the deficits in lung function associated with in utero tobacco exposure. This offers potential preventative targets in anti-oxidant pathways for at-risk infants of smoking mothers.

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