Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience

&NA; The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in the field have struggled to decipher the cellular and molecular processes underlying chronic bronchitis and emphysema. Studies in the past 20 years have underscored that the tissue destruction, notably in emphysema, involves a multitude of injurious stresses, with progressive engagement of endogenous destructive processes triggered by decades of exposure to cigarette smoke and/or pollutants. These lead to an aged lung, with evidence of macromolecular damage that is unlikely to repair. Here we discuss these key pathogenetic elements in the context of organismal evolution as this concept may best capture the challenges facing chronic obstructive pulmonary disease.

• Publication year

  2018

• Venue

  Annals of the American Thoracic Society

• Publication date

  2018-12-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1513/AnnalsATS.201808-583MGPMID 30759011PMCID PMC6944393
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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