Effects of vitamins E and C combined with β-carotene on cognitive function in the elderly

The aim of the present study was to investigate the effect of vitamins E (VE) and C (VC), combined with β-carotene (β-C), on cognitive function in the elderly. A total of 276 elderly subjects completed the prospective study following treatment with VE, VC and different doses of β-C or with VE only. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale (HDS) tests. The plasma levels of amyloid-β (Aβ) and estradiol (E2) were determined by radioimmunoassay (RIA). Results from the MMSE and HDS assessments indicated that the treatment strategy of VE and VC combined with β-C significantly improved cognitive function in the elderly subjects, particularly with higher doses of β-C. Furthermore, RIA suggested that treatment with these vitamins could markedly reduce plasma Aβ levels and elevate plasma E2 levels. The present findings suggest that treatment with VE, VC and β-C results in promising improvements in cognitive function in the elderly.

• Publication year

  2015

• Venue

  Experimental and Therapeutic Medicine

• Publication date

  2015-02-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.3892/etm.2015.2274PMID 25780457PMCID 4353806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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