Cofactors required for TLR7- and TLR9-dependent innate immune responses.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cell Host and Microbe

• Publication date

  2012-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.chom.2012.02.002PMID 22423970PMCID PMC3310399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Systematic discovery of TLR signaling components delineates viral-sensing circuits.

  2011cited by this paper
• TLR signaling is required for Salmonella typhimurium virulence.

  2011cited by this paper
• Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections

  2011cited by this paper
• ESCRT Proteins and Cell Signalling

  2011cited by this paper
• Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.

  2011cited by this paper
• The emerging role of metabolic regulation in the functioning of Toll‐like receptors and the NOD‐like receptor Nlrp3

  2011cited by this paper
• Pathogen Recognition by the Innate Immune System

  2011cited by this paper
• Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

  2010cited by this paper
• Intracellular toll-like receptors.

  2010cited by this paper
• Pattern recognition receptors and inflammation.

  2010influential reference
• Endocytic pathway is required for Drosophila Toll innate immune signaling

  2010cited by this paper
• Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients.

  2010cited by this paper
• Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

  2010cited by this paper
• Human Host Factors Required for Influenza Virus Replication

  2010cited by this paper
• The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

  2010cited by this paper
• Mitochondrial Mutations Contribute to HIF1α Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma

  2009cited by this paper
• Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells.

  2009cited by this paper
• Cell biology of the ESCRT machinery.

  2009cited by this paper
• ESCRT‐I Function is Required for Tyrp1 Transport from Early Endosomes to the Melanosome Limiting Membrane

  2009cited by this paper
• The role of innate immune responses in autoimmune disease development.

  2009cited by this paper
• Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

  2008cited by this paper
• UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

  2008cited by this paper
• Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response*

  2008cited by this paper
• Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

  2008influential reference
• Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

  2008cited by this paper
• The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

  2008cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• A probability-based approach for the analysis of large-scale RNAi screens

  2007cited by this paper
• ESCRTing proteins in the endocytic pathway.

  2007influential reference
• TLR signaling.

  2006cited by this paper
• Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

  2006cited by this paper
• Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity

  2006cited by this paper
• Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus

  2006cited by this paper
• TLR signaling.

  2006cited by this paper
• Pathogen recognition and innate immunity.

  2006cited by this paper
• Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

  2005cited by this paper
• Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling

  2005cited by this paper
• Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

  2005influential reference
• In silico gene function prediction using ontology-based pattern identification

  2005cited by this paper
• Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

  2005cited by this paper
• Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

  2004cited by this paper
• The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

  2004cited by this paper
• Sphingolipids and the immune system.

  2003influential reference
• The anti-Sm immune response in autoimmunity and cell biology.

  2003cited by this paper
• Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

  2003cited by this paper
• Large-scale analysis of the human and mouse transcriptomes

  2002cited by this paper
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

  1999cited by this paper
• Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

  1998cited by this paper
• Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C

  1996influential reference
• Electrotransformation of Streptococcus pyogenes with plasmid and linear DNA.

  1991influential reference
• Chromatin Modifications and Their Function

  year unknowncited by this paper

• Virus-Induced MicroRNA Modulation and Systemic Sclerosis Disease

  2024cites this paper
• The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage

  2023cites this paper
• The Roles of Noncoding RNAs in Systemic Sclerosis

  2022cites this paper
• Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease.

  2022cites this paper
• The gliadin p31-43 peptide: Inducer of multiple proinflammatory effects.

  2021cites this paper
• Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

  2021cites this paper
• Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis

  2021cites this paper
• Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response

  2020cites this paper
• Kinase inhibition in autoimmunity and inflammation

  2020cites this paper
• Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation

  2020influential citation
• B Cell αv Integrins Regulate TLR-Driven Autoimmunity

  2020cites this paper
• Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes

  2019influential citation
• Genomic loci associated with antibody-mediated immune responses in an F2 chicken population.

  2019cites this paper
• Host Cell modulation by Brucella effectors

  2019cites this paper
• Diagnosis of gluten-related enteropathy in a newborn: how and when?

  2019cites this paper
• Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination.

  2019cites this paper
• Viruses Seen by Our Cells: The Role of Viral RNA Sensors

  2018cites this paper
• Constitutively Bound EGFR–Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal

  2018cites this paper
• Extracellular RNA Sensing by Pattern Recognition Receptors

  2018cites this paper
• P31–43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: a role in celiac disease

  2018cites this paper
• HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection

  2017cites this paper
• A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors

  2017cites this paper
• Systems-based Analysis of RIG-I-dependent Signaling Identifies KHSRP as an Inhibitor of RIG-I Receptor Activation

  2017cites this paper
• Microbe‐inducible trafficking pathways that control Toll‐like receptor signaling

  2017cites this paper
• The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

  2017cites this paper
• Identification of novel regulators of the Nuclear Factor Kappa B pathway in human macrophages

  2017cites this paper
• Nucleic acid-sensing TLRs: trafficking and regulation.

  2017cites this paper
• Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro

  2016cites this paper
• Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance

  2015cites this paper
• Recent strategies and progress in identifying host factors involved in virus replication

  2015cites this paper
• Gene expression changes in macrophages infected with pathogenic M. tuberculosis and non-pathogenic M. smegmatis and M. bovis BCG

  2014cites this paper
• Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro

  2014cites this paper
• Trafficking of endosomal Toll-like receptors.

  2014cites this paper
• Positive Regulation of TRAF6-Dependent Innate Immune Responses by Protein Phosphatase PP1-γ

  2014cites this paper
• A Genome-wide Small Interfering RNA (siRNA) Screen Reveals Nuclear Factor-κB (NF-κB)-independent Regulators of NOD2-induced Interleukin-8 (IL-8) Secretion*

  2014cites this paper
• (+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.

  2013cites this paper
• EBI2 Is a Negative Regulator of Type I Interferons in Plasmacytoid and Myeloid Dendritic Cells

  2013cites this paper
• Toll-Like Receptors in Atherosclerosis

  2013cites this paper
• TLR7 Gln11Leu single nucleotide polymorphism in patients with sarcoidosis.

  2013cites this paper
• Evading Innate and Adaptive Immunity During Adenovirus Cell Entry

  2013cites this paper
• From genetics of inflammatory bowel disease towards mechanistic insights.

  2013cites this paper
• A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways

  2013cites this paper
• Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors

  2013cites this paper
• Understanding Pattern Recognition Receptor Signaling and its Effect on Hematopoietic Stem Cells.

  2013cites this paper
• UNC93B1 mediates differential trafficking of endosomal TLRs

  2013influential citation
• TLR-9 Contributes to the Antiviral Innate Immune Sensing of Rodent Parvoviruses MVMp and H-1PV by Normal Human Immune Cells

  2013cites this paper