The Protein Trinity: Structure/Function Relationships That Include Intrinsic Disorder

INTRODUCTION. The current, dominant view relating protein structure to function can be expressed as amino acid sequence → 3-D structure → function. Currently, more than 200 counter examples in which function depends on nonfolded or incompletely folded regions of protein have been described. Furthermore, reviews on intrinsically disordered proteins are beginning to appear[1,2,3]. In one of these reviews, it is suggested that the existence of proteins with intrinsic protein disorder calls for a re-assessment of the protein structure-function paradigm[3].

• Publication year

  2002

• Venue

  TheScientificWorldJournal

• Publication date

  2002-06-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1100/tsw.2002.25PMID 29973799PMCID 6009265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FEBS Lett

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