Chapter 9. Agents for the Treatment of Peptic Ulcer Disease

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Annual Reports in Medicinal Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0065-7743(08)60685-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of omeprazole on gastric secretion in H+,K+-ATPase and in pepsinogen-rich cell fractions from rabbit gastric mucosa.

  1984cited by this paper
• Action of omeprazole (a benzimidazole derivative) on secretory responses to sham feeding and pentagastrin and upon serum gastrin and pancreatic polypeptide in duodenal ulcer patients.

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• Inhibition of gastric acid secretion by selective and nonselective anticholinergics.

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• Effects of omeprazole, a substituted benzimidazole, on gastrointestinal secretions, serum gastrin, and gastric mucosal blood flow in dogs

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• Comparison of nitrosocimetidine with nitrosomethylnitroguanidine in chronic feeding tests in rats.

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• Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex

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• Kinetics of antisecretory action of a new H2-antagonist, YM-11170, in conscious dogs.

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• Evidence for a functional cytoprotective effect produced by antacids in the rat stomach.

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• Studies of the pH gradient and thickness of frog gastric mucus gel.

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• Comparison of the effects of histamine H2-receptor antagonists on prolactin secretion in the rat.

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• Failure of 16,16-dimethyl-PGE2 to protect the human stomach from taurocholate induced damage.

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• Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazole.

  1983cited by this paper
• Morphologic correlates of "cytoprotection".

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• Pirenzepine and exocrine secretions: a selective agent for gastric glands?

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• Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.

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• Effects of non-steroidal anti-inflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro

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• Dose-response study of omeprazole on meal-stimulated gastric acid secretion and gastrin release.

  1983cited by this paper
• Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.

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• Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial.

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• Central and peripheral sites of action for the protective effect of opioids of the rat stomach.

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• Partial prevention of ethanol damage of human gastroduodenal mucosa by prostaglandin E2 in vitro.

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• Studies of the 'mucus-bicarbonate' barrier on rat fundic mucosa: the effects of luminal pH and a stable prostaglandin analogue.

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• Effects of pirenzepine and atropine on vagal and cholinergic gastric secretion and gastrin release and on heart rate in the dog.

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• Comparative randomized, double-blind study of oxmetidine versus cimetidine for short-term treatment of duodenal and prepyloric ulceration.

  1983cited by this paper
• Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2.

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• Oral tripotassium-dicitratobismuthate in gastric and duodenal ulceration

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• Clinical Pharmacokinetics of Cimetidine

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• Comparative Pharmacodynamics and Pharmacokinetics of Cimetidine and Ranitidine

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• Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release.

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• 4-(Diphenylmethyl)-1-[(imino)methyl]piperidines as gastric antisecretory agents.

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• Effect of ranitidine and cimetidine twice daily on the 24 h intragastric acidity in man.

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• Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-receptor antagonists.

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• Histamine H2‐Antagonists‐Past, Present and Future

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• Inhibition of gastric acid secretion by omeprazole in the dog and rat.

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• Omeprazole provides protection against experimentally induced gastric mucosal lesions.

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• Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine.

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• Effect of a new potent H2-receptor antagonist 3[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2- sulfamoylpropionamidine (YM-11170) on gastric mucosal histamine-sensitive adenylate cyclase from guinea pig.

  1983cited by this paper
• RANITIDINE AND LOWER OESOPHAGEAL SPHINCTER PRESSURE

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• Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells.

  1983cited by this paper
• Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives.

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• Modulation of acid secretion from enriched guinea pig parietal cells by opioid receptors.

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• Effects of 16,16-dimethyl-PGE2-methyl ester on aspirin- and indomethacin-induced gastric and intestinal lesions in mini pigs.

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• Effect of a prostaglandin analogue, SC‐30249, on canine gastric secretion

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• Radioimmunoassay of loxtidine and lamtidine in biological fluids

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• Comparative nitrosation of etintidine and cimetidine

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• Duodenal ulcer: does pathophysiology equal aetiology?

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• Prostaglandin-induced bicarbonate secretion in the canine stomach: characteristics and evidence for a cholinergic mechanism.

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• Natural history of duodenal ulcer.

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• Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion.

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• Effect of daily oral omeprazole on 24 hour intragastric acidity.

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• Arhus County Vagotomy Trial: gastric secretory alterations during the first year after selective gastric and parietal cell vagotomy.

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• Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat.

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• Gastric juice electrolyte secretion in conscious dogs with gastric fistulae and its modification by FPL 52694, a mast cell stabilizing agent

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• The ultrastructural localisation of de‐nol (colloidal tripotassium dicitrato‐bismuthate—TDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration

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• New drugs. H2 receptor antagonists--cimetidine and ranitidine.

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• Prostanoid synthesis by cultured gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer.

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• Evidence that proglumide and benzotript antagonize secretagogue stimulation of isolated gastric parietal cells.

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• Comparative study of cimetidine and trimipramine in the short-term treatment of duodenal and gastric ulcer.

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• The metabolism of loxtidine in rat and dog

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• Lessons from The U.S. Multicenter Trial of Ranitidine Treatment for Duodenal Ulcer

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• Prostaglandin cytoprotection and lysosomal stability in acute canine gastric erosions.

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• Studies on the mechanisms of the antisecretory and cytoprotective actions of SCH 28080.

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• The effect of atropine, cimetidine and FPL 52694 on duodenal ulcers in mice.

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• Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells.

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• Effects of four H2 histamine antagonists on bethanechol-stimulated acid and pepsin secretion in the dog.

  1983cited by this paper
• Inhibition of pentagastrin-stimulated and overnight gastric secretion by mianserin.

  1983cited by this paper
• The effect of a gastrin-receptor antagonist on gastric acid secretion and serum gastrin in the Zollinger-Ellison syndrome.

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• Irreversible and specific inactivation by AH 22216 of histamine H2 receptors in the human gastric cancer cell line HGT-1.

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• Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.

  1983cited by this paper
• The possible role of bicarbonate in mucosal protection and peptic ulceration.

  1983cited by this paper
• H2 receptor antagonists—cimetidine and ranitidine

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• Reduction by cytoprotective agents of ethanol-induced damage to the rat gastric mucosa: a correlated morphological and physiological study.

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• Long-term treatment of duodenal ulcer with trimipramine. A double-blind study.

  1982cited by this paper
• Pirenzepine (LS 519): a weak inhibitor of acid secretion by isolated rat parietal cells.

  1982cited by this paper
• Letter: Insulin extraction and hepatic blood-flow.

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• Molecular and crystal structures of 2-(2-pyridyl)thioacetamide derivatives and possible relationship with inhibitory activity for gastric acid secretion.

  1991cites this paper