An improved Francisella tularensis live vaccine strain (LVS) is well tolerated and highly immunogenic when administered to rabbits in escalating doses using various immunization routes.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Vaccine

• Publication date

  2008-03-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.vaccine.2008.01.005PMID 18308432PMCID PMC2678717
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mucosal Immunopathogenesis of Francisella tularensis

  2007cited by this paper
• Animal Models of Francisella tularensis Infection

  2007influential reference
• Vaccines Against Francisella Tularensis

  2007influential reference
• From rabbits to humans: the contributions of Dr. Theodore E. Woodward to tularemia research.

  2007cited by this paper
• Inactivated Francisella tularensis Live Vaccine Strain Protects against Respiratory Tularemia by Intranasal Vaccination in an Immunoglobulin A-Dependent Fashion

  2007cited by this paper
• Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- dependent mechanism.

  2005cited by this paper
• Vaccination strategies for Francisella tularensis.

  2005influential reference
• A novel screening ELISA and a confirmatory Western blot useful for diagnosis and epidemiological studies of tularemia

  2005cited by this paper
• Tularaemia: bioterrorism defence renews interest in Francisella tularensis

  2004cited by this paper
• Comparison of Enzyme-Linked Immunosorbent Assay, Western Blotting, Microagglutination, Indirect Immunofluorescence Assay, and Flow Cytometry for Serological Diagnosis of Tularemia

  2004cited by this paper
• Tularaemia

  2003cited by this paper
• Virulence determinants and protective antigens of Francisella tularensis.

  2003cited by this paper
• Tularemia

  2002cited by this paper
• Tularemia as a biological weapon: medical and public health management.

  2001cited by this paper
• HUMORAL IMMUNE RESPONSE OF COTTONTAIL RABBITS NATURALLY INFECTED WITH FRANCISELLA TULARENSIS IN SOUTHERN ILLINOIS

  1997cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Francisella tularensis: host-parasite interaction.

  1996cited by this paper
• The tularaemia vaccine.

  1994cited by this paper
• Cell-mediated and humoral immune responses induced by scarification vaccination of human volunteers with a new lot of the live vaccine strain of Francisella tularensis

  1992cited by this paper
• Microagglutination test for early and specific serodiagnosis of tularemia

  1990cited by this paper
• INFECTIONS WITH FRANCISELLA TULARENSIS BIOVAR PALAEARCTICA IN HARES (LEPUS TUMIDUS, LEPUS EUROPAEUS) FROM SWEDEN

  1988cited by this paper
• Agglutinins and antibodies to Francisella tularensis outer membrane antigens in the early diagnosis of disease during an outbreak of tularemia

  1988cited by this paper
• Humoral immunity induced by a live Francisella tularensis vaccine. Complement fixing antibodies determined by an enzyme-linked immunosorbent assay (CF-ELISA).

  1985cited by this paper
• Cell-mediated and humoral immunity induced by a live Francisella tularensis vaccine

  1982cited by this paper
• Enzyme-Linked Immunosorbent Assay for Immunological Diagnosis of Human Tularemia

  1979cited by this paper
• Immunization against tularemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemia.

  1977cited by this paper
• Microagglutination test for detecting and measuring serum agglutinins of Francisella tularensis.

  1974cited by this paper
• Effect of vaccine, route, and schedule on antibody response of rabbits to Pasteurella tularensis.

  1969cited by this paper
• In Vitro Interactions Between Rabbit Alveolar Macrophages and Pasteurella tularensis

  1966cited by this paper
• Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.

  1961cited by this paper

• Melioidosis vaccines: recent advances and future directions

  2025cites this paper
• From Sequence to Solution: Computational Design of a Multi-Epitope Vaccine Candidate Against Francisella tularensis.

  2025cites this paper
• Current vaccine strategies and novel approaches to combatting Francisella infection

  2024cites this paper
• Marmosets as models of infectious diseases

  2024cites this paper
• The rLVS ΔcapB/iglABC vaccine provides potent protection in Fischer rats against inhalational tularemia caused by various virulent Francisella tularensis strains

  2023cites this paper
• Improvement of Approaches to the Verification of the Vaccine Strain Francisella tularensis 15 NIIEG during Long-Term Storage

  2022cites this paper
• Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia

  2021cites this paper
• Deletion Mutants of Francisella Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal Francisella LVS Challenge in a Murine Model of Respiratory Tularemia

  2021cites this paper
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  2021cites this paper
• Differential Immune Response Following Intranasal and Intradermal Infection with Francisella tularensis: Implications for Vaccine Development

  2021cites this paper
• Francisella and Antibodies

  2021cites this paper
• The O-Ag Antibody Response to Francisella Is Distinct in Rodents and Higher Animals and Can Serve as a Correlate of Protection

  2021cites this paper
• Novel Transcriptional and Translational Biomarkers of Tularemia Vaccine Efficacy in a Mouse Inhalation Model: Proof of Concept

  2021cites this paper
• Proteomic Analysis of Human Immune Responses to Live-Attenuated Tularemia Vaccine

  2020cites this paper
• Tularemia: Epidemiology, Ecology, Genomics, Immunity and Pathogenesis

  2020cites this paper
• Inhibition of Francisella tularensis phagocytosis using a novel anti-LPS scFv antibody fragment

  2019cites this paper
• A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin.

  2019cites this paper
• Systems Vaccinology for a Live Attenuated Tularemia Vaccine Reveals Unique Transcriptional Signatures That Predict Humoral and Cellular Immune Responses

  2019cites this paper
• A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis

  2018cites this paper
• Adaptive Immunity to Francisella tularensis and Considerations for Vaccine Development

  2018cites this paper
• Aerosol prime-boost vaccination provides strong protection in outbred rabbits against virulent type A Francisella tularensis

  2018cites this paper
• Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis

  2018cites this paper
• Tularemia vaccine: Safety, reactogenicity, "Take" skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial.

  2017cites this paper
• Progress, challenges, and opportunities in Francisella vaccine development

  2016cites this paper
• Humoral response to Type-A derived genetically modified live attenuated Francisella tularensis in rabbits

  2016cites this paper
• 229 – Francisella tularensis (Tularemia)

  2015cites this paper
• Francisella tularensis Vaccines Elicit Concurrent Protective T- and B-Cell Immune Responses in BALB/cByJ Mice

  2015cites this paper
• Live Attenuated Mutants of Francisella tularensis Protect Rabbits against Aerosol Challenge with a Virulent Type A Strain

  2014cites this paper
• A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia

  2013cites this paper
• Infectious Diseases of Domestic Rabbits

  2013cites this paper
• Live attenuated tularemia vaccines: recent developments and future goals.

  2013cites this paper
• Role of Innate Host Defenses in Acute and Vaccination Models of Pneumonic Tularemia

  2012cites this paper
• BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune responses.

  2012cites this paper
• A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy

  2012cites this paper
• Immunoproteomic analysis of the human antibody response to natural tularemia infection with Type A or Type B strains or LVS vaccination.

  2011cites this paper
• Animal Models in Biodefense Research

  2011cites this paper
• Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine.

  2011cites this paper
• Measurement of macrophage-mediated killing of intracellular bacteria, including Francisella and mycobacteria.

  2011cites this paper
• The Francisella Tularensis Proteome and its Recognition by Antibodies

  2011cites this paper
• Tularemia vaccines: recent developments and remaining hurdles.

  2011cites this paper
• Pneumonic Tularemia in Rabbits Resembles the Human Disease as Illustrated by Radiographic and Hematological Changes after Infection

  2011cites this paper
• Immunoproteomics Analysis of the Murine Antibody Response to Vaccination with an Improved Francisella tularensis Live Vaccine Strain (LVS)

  2010influential citation
• The Challenge of Highly Pathogenic Microorganisms

  2010cites this paper
• Francisella tularensis (Tularemia)

  2010cites this paper
• Novel Live Vaccine Candidates Against Airborne Francisella tularensis

  2010cites this paper
• Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.

  2010cites this paper
• Francisella virulence: significant advances, ongoing challenges and unmet needs

  2009cites this paper
• Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humans.

  2009influential citation
• Francisella tularensis vaccines.

  2009cites this paper
• Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody.

  2008cites this paper