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Biomedical insights into cell adhesion and migration—from a viewpoint of central nervous system tumor immunology

M. Fujita,Takaaki Matsui,A. Ito

Published 2015 in Front. Cell Dev. Biol.

ABSTRACT

Cell adhesion and migration is a central process in the development and maintenance of multicellular organisms (Friedl et al., 2012). Tissue formation during embryonic development, wound healing, and immune responses all require the fine-tuned, orchestrated movement of cells. In this regard, recent cutting-edge studies have elucidated how cell adhesion and migration achieve three-dimensional collective cell movement (Rørth, 2012; Matsui et al., 2015). That is, collective cell movement uses a mechanical guidance system where each cell in the cell groups individually but coordinately guides the global motion of the cell groups. This mechanism is involved in a variety of biological reactions such as embryonic morphogenesis, organogenesis, immune reactions, and/or carcinogenesis (Friedl and Gilmour, 2009). In this review article, we will particularly pick up immune reactions in central nervous system (CNS) and CNS tumors to look into the fine-tuned mechanisms how cell adhesion and migration are involved in physiological condition as well as pathological conditions.

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