Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cardiovascular Research

• Publication date

  1998-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0008-6363(98)00111-4PMID 9798534
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heterotrimeric G proteins.

  1996cited by this paper
• Heterotrimeric G proteins: organizers of transmembrane signals.

  1995cited by this paper
• Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel.

  1994cited by this paper
• Representation of tactile roughness in thalamus and somatosensory cortex.

  1994cited by this paper
• Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

  1994cited by this paper
• Conditional regulation of adenylyl cyclases by G-protein βγ-subunits

  1993cited by this paper
• Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.

  1993cited by this paper
• Conditional regulation of adenylyl cyclases by G-protein beta gamma-subunits.

  1993cited by this paper
• DOCA-salt hypertensive rat hearts exhibit altered expression of G-proteins.

  1993cited by this paper
• Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

  1992cited by this paper
• Guanine nucleotide regulatory protein levels and function in spontaneously hypertensive rat vascular smooth-muscle cells.

  1992cited by this paper
• Altered expression of G‐protein mRNA in spontaneously hypertensive rats

  1992cited by this paper
• Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.

  1992cited by this paper
• Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI.

  1992cited by this paper
• Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.

  1992cited by this paper
• Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

  1992cited by this paper
• Gz-mediated hormonal inhibition of cyclic AMP accumulation.

  1992cited by this paper
• Signal Transduction by G Proteins in Cardiac Tissues

  1992cited by this paper
• Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.

  1992cited by this paper
• Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.

  1992cited by this paper
• Adenylyl cyclases.

  1992cited by this paper
• Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.

  1991cited by this paper
• Diversity of G proteins in signal transduction

  1991cited by this paper
• Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.

  1991cited by this paper
• Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats.

  1991cited by this paper
• Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system.

  1990cited by this paper
• Atrial natriuretic peptide receptors in renal papilla of DOCA-salt hypertensive rats.

  1990cited by this paper
• Angiotensin II receptors negatively coupled to adenylate cyclase in rat myocardial sarcolemma. Involvement of inhibitory guanine nucleotide regulatory protein.

  1989cited by this paper
• One Hour of Myocardial Ischemia Decreases the Activity of the Stimulatory Guanine-Nucleotide Regulatory Protein Gs

  1989cited by this paper
• The G protein-gated atrial K+ channel is stimulated by three distinct Gi alpha-subunits.

  1988cited by this paper
• Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure-overload left ventricular failure.

  1988cited by this paper
• Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

  1988cited by this paper
• The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

  1988cited by this paper
• Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

  1988cited by this paper
• Reduced function of the stimulatory GTP-binding protein in beta adrenoceptor-adenylate cyclase system of femoral arteries isolated from spontaneously hypertensive rats.

  1988cited by this paper
• Altered responsiveness of adenylate cyclase to adenosine and other agents in the myocardial sarcolemma and aorta of spontaneously-hypertensive rats.

  1988cited by this paper
• Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats.

  1988cited by this paper
• Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Decreased density of vascular receptors for atrial natriuretic peptide in DOCA-salt hypertensive rats.

  1987cited by this paper
• Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.

  1987cited by this paper
• G proteins: transducers of receptor-generated signals.

  1987cited by this paper
• Rat heart cell membranes contain three substrates for cholera toxin-catalyzed ADP-ribosylation and a single substrate for pertussis toxin-catalyzed ADP-ribosylation

  1986cited by this paper
• Molecular basis for two forms of the G protein that stimulates adenylate cyclase.

  1986cited by this paper
• Human cDNA clones for four species of G alpha s signal transduction protein.

  1986cited by this paper
• Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

  1986cited by this paper
• Rat heart cell membranes contain three substrates for cholera toxin-catalyzed ADP-ribosylation and a single substrate for pertussis toxin-catalyzed ADP-ribosylation.

  1986cited by this paper
• A role for Ni in the hormonal stimulation of adenylate cyclase

  1985cited by this paper
• Angiotensin II receptors negatively coupled to adenylate cyclase in rat aorta.

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.

  1982cited by this paper
• Reduced number of β-adrenergic receptors in the myocardium of spontaneously hypertensive rats

  1978cited by this paper
• Interaction of acetylcholine and epinephrine on heart cyclic AMP-dependent protein kinase.

  1978cited by this paper
• Reduced number of beta-adrenergic receptors in the myocardium of spontaneously hypertensive rats.

  1978cited by this paper
• Circulating Catecholamine Levels in Human and Experimental Hypertension

  1976cited by this paper
• Cyclic AMP metabolism in the cardiac tissue of the spontaneously hypertensive rat.

  1976cited by this paper
• Control of calcium transport in the myocardium by the cyclic AMP-Protein kinase system.

  1975cited by this paper
• Cyclic nucleotides and smooth muscle.

  1974cited by this paper
• A highly sensitive adenylate cyclase assay.

  1974cited by this paper
• Cyclic nucleotides and smooth muscle.

  1974cited by this paper
• Adenyl cyclase-phosphodiesterase system in arterial smooth muscle.

  1972cited by this paper
• Differences of cardiac reactivity between spontaneously hypertensive and normotensive rats.

  1972cited by this paper
• Adenylcyclase-phosphodiesterase system in arterial smooth muscle

  1972cited by this paper
• Effect of catecholamines and angiotensin on cyclic AMP in rat aorta and tail artery.

  1971cited by this paper
• Turnover and synthesis of norepinephrine in experimental hypertension in rats.

  1969cited by this paper
• Cardiovascular Research

  1966cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Sirtuin1 inhibitor attenuates hypertension in spontaneously hypertensive rats: role of Giα proteins and nitroxidative stress

  2022cites this paper
• Role of Gi proteins in the regulation of blood pressure and vascular remodeling.

  2022cites this paper
• Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Giα proteins and hyperproliferation of vascular smooth muscle cells.

  2021cites this paper
• Local cyclic adenosine monophosphate signalling cascades—Roles and targets in chronic kidney disease

  2021cites this paper
• Resveratrol prevents the development of high blood pressure in spontaneously hypertensive rats through the inhibition of enhanced expression of Giα proteins.

  2019cites this paper
• Inhibition of overexpression of Giα proteins and nitroxidative stress contribute to sodium nitroprusside‐induced attenuation of high blood pressure in SHR

  2018cites this paper
• Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling

  2017cites this paper
• Enhanced expression of Giα proteins contributes to the hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats via MAP kinase- and PI3 kinase-independent pathways.

  2016cites this paper
• Adenosine A3 Receptor: A Promising Therapeutic Target in Cardiovascular Disease

  2016cites this paper
• Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells.

  2016cites this paper
• Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα‐2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats

  2016cites this paper
• Role of Gi Proteins in Hypertension

  2015cites this paper
• Effect of knockdown of Giα proteins using antisense oligodeoxynucleotides encapsulated in cationic liposomes on the development of hypertension in spontaneously hypertensive rats

  2014cites this paper
• Regulation of Giα protein expression by vasoactive peptides in hypertension: molecular mechanisms.

  2014cites this paper
• Natriuretic Peptide Receptor-C Attenuates Hypertension in Spontaneously Hypertensive Rats: Role of Nitroxidative Stress and Gi Proteins

  2014cites this paper
• An overview of the modulatory effects of oleic acid in health and disease.

  2013cites this paper
• cAMP attenuates the enhanced expression of Gi proteins and hyperproliferation of vascular smooth muscle cells from SHR: role of ROS and ROS-mediated signaling.

  2013cites this paper
• The Hypertrophied Heart

  2012influential citation
• Le niveau réduit d’AMPc dans la surexpression des protéines G(alpha)i et la prolifération accrue des cellules du muscle lisse vasculaire des rats spontanément hypertendus

  2012cites this paper
• Hydrogen peroxide enhances the expression of Giα proteins in aortic vascular smooth cells: role of growth factor receptor transactivation.

  2012cites this paper
• Hydrogen peroxide enhances the expression and function of Giα proteins in aortic vascular smooth muscle cells from Sprague-Dawley rats : role of growth factor receptors transactivation

  2011cites this paper
• Effect of Concomitant Administration of a-tocopherol and ACEI on Cardiovascular Performance and Nucleic Acid Changes in DOCA Hypertensive Rats

  2011cites this paper
• Transactivation of epidermal growth factor receptor by enhanced levels of endogenous angiotensin II contributes to the overexpression of Giα proteins in vascular smooth muscle cells from SHR.

  2011cites this paper
• Modulation of Gi Protein Expression in Hypertension: Molecular Mechanisms

  2011cites this paper
• Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: Role of growth factor receptor activation.

  2011cites this paper
• Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

  2010cites this paper
• Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.

  2010cites this paper
• Modulation of Gi Proteins in Hypertension: Role of Angiotensin II and Oxidative Stress

  2010cites this paper
• Oleic acid content is responsible for the reduction in blood pressure induced by olive oil

  2008cites this paper
• Peroxynitrite inhibits the expression of G(i)alpha protein and adenylyl cyclase signaling in vascular smooth muscle cells.

  2008cites this paper
• Implication of G-proteins in Cardiovascular Disease

  2008cites this paper
• Activator of G‐protein Signaling 3 null mice: unexpected alterations in metabolic and cardiovascular function

  2008cites this paper
• RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.

  2008cites this paper
• Reduced levels of cyclic AMP contribute to the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats.

  2008cites this paper
• Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells

  2007cites this paper
• Enhanced expression of Gialpha protein and adenylyl cyclase signaling in aortas from 1 kidney 1 clip hypertensive rats.

  2006cites this paper
• Nitric oxide modulates Gi-protein expression and adenylyl cyclase signaling in vascular smooth muscle cells.

  2006cites this paper
• Dysfunction of paracellin-1 by dephosphorylation in Dahl salt-sensitive hypertensive rats.

  2006cites this paper
• Enhanced expression of Giα protein and adenylyl cyclase signaling in aortas from 1 kidney 1 clip hypertensive ratsThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

  2006cites this paper
• Oxidative stress contributes to the enhanced expression of Giα proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats

  2005cites this paper
• β-Adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats

  2005cites this paper
• Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells.

  2005cites this paper
• Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats.

  2005cites this paper
• Abnormal regulation of G protein αi2 subunit in skin fibroblasts from insulin-resistant hypertensive individuals

  2004cites this paper
• Redox Modulation of Gi Protein Expression and Adenylyl Cyclase Signaling: Role of Nitric Oxide

  2004influential citation
• Losartan-induced attenuation of blood pressure in l-NAME hypertensive rats is associated with reversal of the enhanced expression of Giα proteins

  2004cites this paper
• 2-Hydroxyoleic Acid: A New Hypotensive Molecule

  2004cites this paper
• Preparation of Cell Membranes From Left Ventricles and Aortas

  2004cites this paper
• [Impairment of atypical beta-adrenergic-mediated relaxation in spontaneously hypertensive rats before and during the development of arterial hypertension].

  2003cites this paper
• Modulation of Atrial Natriuretic Peptide (ANP)-C Receptor and Associated Signaling by Vasoactive Peptides

  2003cites this paper
• Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle

  2002cites this paper
• Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells.

  2002cites this paper
• Inactivation of Enhanced Expression of Gi Proteins by Pertussis Toxin Attenuates the Development of High Blood Pressure in Spontaneously Hypertensive Rats

  2002cites this paper
• Role of the parasympathetic nervous system and interaction with the sympathetic nervous system in the early phase of hypertension.

  2000cites this paper
• Vascular beta-adrenoceptor function in hypertension and in ageing.

  2000cites this paper
• Heterotrimeric G proteins in heart disease.

  2000cites this paper
• A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice.

  2000cites this paper
• Vascular β-adrenoceptor function in hypertension and in ageing

  2000cites this paper
• Enhanced expression of Gi proteins in non‐hypertrophic hearts from rats with hypertension‐induced by L‐NAME treatment

  2000cites this paper
• Angiotensin II-induced changes in G-protein expression and resistance of renal microvessels in young genetically hypertensive rats

  2000cites this paper
• Heterotrimeric G proteins in heart disease 1

  2000cites this paper
• Volume overload cardiac hypertrophy exhibits decreased expression of Gsα and not of Giα in heart

  2000cites this paper
• Role of G Proteins in Hypertension and Hypertrophy

  2000cites this paper
• Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.

  2000cites this paper
• Changes in Gene Expression during the Transition from Compensated Hypertrophy to Heart Failure

  1999cites this paper
• G-protein and Membrane Signaling in Cardiovascular Disease

  1997cites this paper